Zinc l‐pyrrolidone carboxylate inhibits the UVA‐induced production of matrix metalloproteinase‐1 by in vitro cultured skin fibroblasts, whereas it enhances their collagen synthesis

Abstract

Reduced collagen matrix in the dermis constitutes one of the characteristic features of chronologically aged skin, which is further enhanced on the sun-exposed portions of the body by chronic ultraviolet light (UV) irradiation, inducing the unique changes associated with skin photoageing. The zinc salt of l-pyrrolidone carboxylate (Zinc PCA) has long been used as a cosmetic ingredient, because of its astringent and anti-microbial properties. In the present study, by employing cultured normal human dermal fibroblasts, we found that Zinc PCA suppressed UVA-induced activation of activator protein-1 (AP-1) and reduced matrix metalloproteinase-1 production in these cells, which is thought to be involved in collagen degradation in photoaged skin. Moreover, Zinc PCA treatment of the cells increased the expression of an ascorbic acid transporter mRNA, SVCT2, but not SVCT1, resulting in the enhanced production of type I collagen. Based on these in vitro findings, we consider Zinc PCA to be a promising candidate for an anti-skin ageing agent.

Exploring Anti-Fungal, Anti-Microbial and Anti-Inflammatory Properties of a Topical Non-Steroidal Barrier Cream in Face and Chest Seborrheic Dermatitis

“…The mechanism of action of this fragrance-free product may be related to multiple synergy of the main ingredients, that include: (1) piroctone olamine with anti-fungal and anti-microbial properties [32], (2) biosaccharide gum-2, an anti-inflammatory and soothing active ingredient protecting skin against external aggressions, that lead to dehydration [33] with recently demonstrated antifungal properties (patent pending WO2019020822), (3) stearyl glycyrrhetinate, a salt and ester of glycyrrhetinic acid that exhibits anti-inflammatory, soothing and anti-pruritic effects [34], and (4) zinc PCA which combines anti-inflammatory properties with anti-seborrheic efficacy [18]. We are aware that our study has some limitations: it was an open study from a single center, the number of patients was limited, and there was no control group treated with the vehicle without active ingredients.…”

“…To date, it is available a novel nonsteroidal cream (NSC) containing different ingredients, which have been reported to exert effects in SD treatment [14]. In particular, this cosmeceutical is composed of: (1) piroctone olamine, that has an anti-fungal property [15][16][17]; (2) zinc salt of L-pyrrolidone carboxylate (PCA), that has anti-fungal and anti-inflammatory properties [18][19][20];…”

Lactobacillus sakei Lipoteichoic Acid Inhibits MMP-1 Induced by UVA in Normal Dermal Fibroblasts of Human

“…As UVC is absorbed by the ozone layer, it does not reach the ground. However, as UVA and UVB wavelengths are longer that UVC, they pass through the ozone layer and affect human skin [14,26,27]. UV exposure causes some skin diseases, such as skin cancer, as well as skin aging.…”

“…Skin protects the body from external stress and controls homeostasis, maintaining moisture content and the temperature [19,27]. Skin aging may be explained by both intrinsic and extrinsic factors [4,9,14].…”

Effect of Oral Administration of Lactobacillus plantarum HY7714 on Epidermal Hydration in Ultraviolet B-Irradiated Hairless Mice

“…UV light is divided into UVA, UVB, and UVC depending on the wavelength range. UVC is absorbed by the ozone layer, whereas UVA and UVB pass through the ozone layer and can affect the skin [22,31,35]. UV exposure causes several skin diseases, including skin cancer and premature aging.…”