Zinc, Selenium and Skin Health: Overview of Their Biochemical and Physiological Functions

Berra, B.; Rizzo, Angela Maria

doi:10.1016/b978-0-8155-2029-0.50014-4

Cited by 2 publications

(3 citation statements)

References 78 publications

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“…Analysis of the serum and hepatic mineral concentrations showed a significant reduction in selenium and zinc concentrations, with zinc deficiency being more pronounced, as zinc concentrations were even more than 50% lower than those found normally in the species [ 20 ]. Deficiency of these micronutrients can result in severe damage to different organs and tissues, especially the thyroid gland and skin [ 9 , 30 , 31 , 32 ]. The results of the mineral concentrations indicate a simultaneous selenium and zinc deficiency in sheep.…”

Section: Discussionmentioning

confidence: 99%

“…Both species had fibrosis and severe thyroid gland atrophy, characterized by degenerated follicles, associated with mononuclear inflammatory cell infiltrate. In another experimental study, the administration of zinc in the diet of rats causes an increase in the concentration of thyroid hormone (T4 and T3) levels and induces a significant reduction in the level of TSH [ 30 ]. It is known that this mineral is a part of and modulates the function of structural proteins [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

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Diffuse Alopecia and Thyroid Atrophy in Sheep

Sampaio

Riet-Correa

Barbosa

et al. 2021

Animals

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Thyroid dysfunction substantially affects the quality of life due to its association with various disorders in different organs. A low intake of selenium and zinc can predispose to thyroid alterations, resulting in hypothyroidism. A deficiency of selenium and zinc causes direct and indirect skin lesions, both by the action of free radicals on the skin and by thyroid dysfunction. The aim of this study was to describe natural cases of diffuse alopecia and thyroid abnormalities in sheep with selenium and zinc deficiency. Five adult sheep presented marked and diffuse alopecia, and the residual hairs were dry and brittle. The skin was thick and crusty, with marked peeling. The triiodothyronine (T3) and thyroxine (T4) serum concentrations were below reference values for the species. Zinc and Se concentrations were low in both the serum and liver. During necropsy, cachexia associated with serous fat atrophy was observed, and the thyroid glands showed marked atrophy. Microscopically, the thyroid presented multifocal to coalescent atrophy, with atrophied and dilated follicles, macrophage infiltration, and the presence of fibrous connective tissue. The skin revealed hyperkeratosis and edema. It is concluded that thyroid atrophy, alopecia, and hyperkeratosis are associated with low serum and liver concentrations of zinc and selenium in sheep.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diffuse Alopecia and Thyroid Atrophy in Sheep

Sampaio

Riet-Correa

Barbosa

et al. 2021

Animals

View full text Add to dashboard Cite

show abstract

“…Zinc deficiency has the potential to worsen skin conditions such as dermatitis and acne. Additionally, the role of zinc in taste and smell perception can lead to changes in these sensory functions (125). Gastrointestinal problems, including diarrhea and impaired nutrient absorption, can further manifest in cases of zinc deficiency (126).…”

Section: Zincmentioning

confidence: 99%

Impact of heavy metals on breast cancer (Review)

Ali,

Nazar,

Mustafa

et al. 2023

World Acad Sci J

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Breast cancer is characterized by the uncontrollable proliferation and dissemination of abnormal cells in the mammary glands. It is a significant cause of mortality among women, with approximately one in eight females experiencing a breast cancer diagnosis in their lifetime. Multiple factors contribute to an elevated risk of developing breast cancer, encompassing sex, lifestyle choices, age, hormone usage, familial predisposition and exposure to environmental pollutants. Environmental pollution refers to the contamination of various components of the Earth's atmosphere, biology and physical systems. Heavy metal pollutants include copper (Cu), cadmium (Cd), nickel (Ni), lead (Pb), zinc (Zn) and manganese (Mn). Exposure to toxic heavy metals through inhalation, skin contact and ingestion poses significant risks to human health and organ function, including the breasts. Essential heavy metals, such as Cu, Zn, cobalt (Co) and iron (Fe), play crucial roles in various biochemical and physiological processes within organisms. Various techniques have been employed to analyze heavy metals, including ultraviolet-visible spectrophotometry, inductively coupled plasma, flame atomic absorption spectrophotometry, graphite furnace atomic absorption spectroscopy, atomic emission spectroscopy and proton-induced X-ray emission. Recent studies have suggested an association between variations in heavy metal metabolism and the occurrence and progression of breast cancer in human populations. Some studies have found increased levels of Cu and Cd and decreased Zn and Mn concentrations in patients with breast cancer compared to individuals without breast cancer. The present review aimed to explore the link between heavy metal exposure and breast cancer, providing insight into its potential effects on breast health and the significance of this association. Overall, heavy metals directly affect human health, particularly as regards breast cancer.

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Zinc, Selenium and Skin Health: Overview of Their Biochemical and Physiological Functions

Cited by 2 publications

References 78 publications

Diffuse Alopecia and Thyroid Atrophy in Sheep

Diffuse Alopecia and Thyroid Atrophy in Sheep

Impact of heavy metals on breast cancer (Review)

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