Zinc Status and Autoimmunity: A Systematic Review and Meta-Analysis

Sanna, Alessandro; Firinu, Davide; Zavattari, Patrizia; Valera, Paolo

doi:10.3390/nu10010068

Cited by 144 publications

(92 citation statements)

References 122 publications

(72 reference statements)

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“…2,3 Results of previous studies suggest that minerals could play a role in MS activity and progression. [4][5][6][7] In one study, imbalances in serum trace elements and decreased serum antioxidant capacity were related to conversion to definite MS after a first clinical event. 5 Yet, disease-related mechanisms or treatment after disease onset could underlie these changes and the evidence for a role of minerals in MS pathogenesis is scarce and preliminary, as based on ecological, cross-sectional, and retrospective studies.…”

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confidence: 99%

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Total intake of different minerals and the risk of multiple sclerosis

et al. 2019

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Objective To investigate the association between mineral intake (potassium, magnesium, calcium, phosphorus, iron, zinc, manganese, copper) and multiple sclerosis (MS) risk. Methods In a prospective cohort study, we assessed dietary and supplemental mineral intake by a validated food frequency questionnaire administered every 4 years to 80,920 nurses in the Nurses' Health Study (1984-2002) and 94,511 in the Nurses' Health Study II (1991-2007). There were 479 new MS cases during follow-up. We estimated hazard ratios and 95% confidence intervals for the association of energy-adjusted mineral intake with MS risk using Cox regression, adjusting for age, residence latitude at age 15, ancestry, body mass index at age 18, supplemental vitamin D, smoking, and total energy intake. Results We did not find any association between the minerals and MS risk, either for baseline or cumulative intake during follow-up. The associations were null comparing women with highest to those with lowest intakes in quintiles or deciles and there was no significant trend for higher intakes (p trend across baseline quintiles: potassium 0.35, magnesium 0.13, calcium 0.22, phosphorus 0.97, iron 0.85, zinc 0.67, manganese 0.48, copper 0.59). Conclusions Our findings suggest that mineral intake is not an important determinant of MS risk.

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confidence: 99%

“…[8][9][10][11][12] Zinc has been of particular interest due to its immune-regulating anti-inflammatory and antioxidant potential. 2,13 While zinc levels seemed to be lower in patients with MS 6 and zinc may ameliorate experimental autoimmune encephalomyelitis, an MS animal model, 14,15 its role in MS etiology is unclear.…”

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confidence: 99%

Total intake of different minerals and the risk of multiple sclerosis

et al. 2019

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“…Zinc levels among patients suffering from different auto-immune disorders appear to be lower than the healthy individuals 32 .…”

Section: Zinc Deficiency Is Associated With Cytokine Stormmentioning

confidence: 85%

Can Zinc Correction in SARS-CoV-2 Patients Improve Treatment Outcomes?

Noeparast¹,

Verschelden²

2020

Preprint

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The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic for which there is no established treatment available yet, has caused more than 68,000 deaths so far. Following the SARS-CoV outbreak in 2003, an Italian group described a hypothesis about the efficacy of two old drugs: Chloroquine (CQ) and Hydroxychloroquine (HCQ), against SARS-CoV and its future emergents. Later, this hypothesis was shown to be relevant in-vitro. Due to the high genetic similarity of SARS-CoV-2 and SARS-CoV, the hypothesis introduced by Savarino et al. and the further supportive in-vitro evidence served a rational ground for three different Chinese groups to test the efficacy of CQ or HCQ against SARS-CoV-2 in-vitro. These studies showed promising in-vitro efficacy of CQ and HCQ against SARS-CoV-2. Unfortunately, in the absence of sufficient clinical data on the (in)efficacy of CQ and HCQ in SARS-CoV-2 patients, the compassionate and off-label use of these medications is becoming politicized. Herein, we underline some critical features of the CQ/HCQ mechanism of action concerning SARS-CoV-2. Moreover, we put forward a hypothesis based on three lines of evidence on a probable link between zinc-deficiency/zinc correction and response to CQ/HCQ- and possibly other SARS-CoV-2 treatments.

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“…Les études épidémiologiques mettent ainsi en évidence, à la fois une plus faible consommation de zinc et des concentrations sériques en zinc plus faibles chez les végétariens, et encore plus chez les végétaliens, que chez les omnivores Foster et al, 2013. Le zinc est impliqué dans de nombreuses fonctions biologiques, et les carences en zinc constituent une préoccupation de santé publique mondiale WHO, 2002, notamment en raison des liens entre le zinc et le système immunitaire (Sanna et al, 2018).…”

Section: La Couverture Des Besoins Nutritionnels Dans Des Régimes Pluunclassified

Quelle place pour les produits animaux dans l’alimentation de demain ?

Rémond

2019

INRA Prod. Anim.

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L’image de l’élevage et des produits alimentaires d’origine animale n’a cessé de se dégrader suite aux crises sanitaires successives, aux problèmes de pollution, et plus récemment à la dénonciation de pratiques d’élevage et d’abattage ne respectant pas le bien-être animal. En réponse à cette détérioration d’image, des modes de consommation « alternatifs » se développent, allant du flexitarisme au végétalisme. Il faut cependant rappeler que sur le plan nutritionnel, en raison de la qualité de leur apport en protéines et minéraux (calcium, fer, zinc), et de leur spécificité dans l’apport en vitamine B12 et en acides gras polyinsaturés à longue chaine, la présence de produits animaux dans l’alimentation garantit une couverture optimale des besoins de notre organisme. Bien que souvent attaqués sur le plan de la santé, il faut également rappeler que les études épidémiologiques ne mettent pas en évidence d’effet négatif de leur consommation lorsque celle-ci est modérée (moins de 50 % de l’apport protéique journalier, moins de 500 g de viande rouge par semaine). Il est clair cependant que dans les pays occidentaux, une consommation excessive de produits animaux a pu déséquilibrer l’alimentation et favoriser l’émergence de pathologies non transmissibles. Aussi, pour les gros consommateurs de produits animaux, une réduction de consommation s’impose. Celle-ci entrainerait une importante réduction (– 30 %) de l’impact environnemental des productions animales. Un élevage respectueux des animaux, minimisant les émissions de gaz à effet de serre et les rejets azotés et maximisant l’utilisation de produits végétaux non consommables par l’Homme, associé à une consommation humaine raisonnable, garantira le maintien des produits animaux dans l’alimentation de demain.

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Zinc Status and Autoimmunity: A Systematic Review and Meta-Analysis

Cited by 144 publications

References 122 publications

Total intake of different minerals and the risk of multiple sclerosis

Total intake of different minerals and the risk of multiple sclerosis

Can Zinc Correction in SARS-CoV-2 Patients Improve Treatment Outcomes?

Quelle place pour les produits animaux dans l’alimentation de demain ?

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