Zinc status improving as a pathogenetically grounded platform for maintaining immunity during SARS-CoV-2 pandemic

Sankova, Maria V.; Kytko, O.V.; Дыдыкина, И. С.; Chilikov, V V; Laptina, V.I.; Markina, A.D.

doi:10.33029/0042-8833-2021-90-2-26-39

Cited by 2 publications

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“…The biochemical basis of zinc activity is considered to be its ability to block the RNA polymerase enzyme, which is necessary for viral replication [25][26][27]. 118 zinc-containing proteins are involved in human antiviral immunity, 11 of which are directly related to protection against single-stranded RNA viruses, which include SARS-CoV-2 [28]. The Zn-dependent protein TRIM5α (tripartite motif-containing proteins -TRIMs) inhibits the release of viral RNA inside the cell.…”

Section: Resultsmentioning

confidence: 99%

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Biologically active food components as an element in the prevention of coronavirus infection: A review

Zakrevskiy,

Nazarenko,

Simakova

et al. 2023

Vestnik SPbSU. Medicine

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Immune cells play a vital role in protecting the human body from pathogens and viruses. The deficiency of a number of nutrients in the diet negatively affects the state of the immune system, which disrupts the chemical, structural, and regulatory processes in the body. The purpose of the article is to consider the role of various biologically active nutrients and bioactive substances in increasing innate and adaptive human immunity for the prevention of COVID-19 in the population. Using the research method of scientific electronic libraries, bibliographic bases of articles on medical sciences, it was found that such vitamins as C, D, A, and E, minerals (zinc, iron, selenium), resveratrol, turmeric flavonoids, garlic, green tea, elderberry extract, biologically active substances from an aqueous extract of wormwood leaves help prevent coronavirus infection or reduce the severity of the disease, having immunomodulatory, anti-inflammatory, antioxidant and antiviral properties. In the context of the ongoing pandemic of coronavirus infection, recommendations for including the biologically active substances described above in the diet can be extrapolated to the entire population to maintain the immune system and the body’s resistance to infection.

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Section: Resultsmentioning

confidence: 99%

“…An increased concentration of zinc prevents the penetration of virions into cells and blocks its reproduction process. Zinc has become even more popular due to the development of the COVID-19 pandemic [28].…”

Section: Resultsmentioning

confidence: 99%

Biologically active food components as an element in the prevention of coronavirus infection: A review

Zakrevskiy,

Nazarenko,

Simakova

et al. 2023

Vestnik SPbSU. Medicine

View full text Add to dashboard Cite

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Features of hemostasis in patients after severe Covid-19 at discharge from the hospital (original study)

Romanov¹,

Архангельская²,

Sharipova³

et al. 2023

Physiotherapist

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Since 2020, the world has been living in the COVID-19 pandemic caused by the SARS-CoV-2 virus. This situation is due to the high virulence and prevalence of the virus, which has reached epidemic proportions in recent years. Hemostasis disorders are the main marker and prognosis of the severe course of the disease. The virus in the body of a patient with COVID-19 triggers a pathophysiological chain reaction, which, in turn, will lead to the development of a cytokine storm, a disorder in the hemostasis system, and the development of multiple organ disorders. The purpose of the study: to determine and study the influence of various factors on the characteristics of hemostasis in patients with moderate and severe COVID-19. The object of the study were patients with moderate and severe forms of the disease. The following methods were used in the study: standard laboratory diagnostics and hair mineralogram. Results. Moderate and severe courses have clear laboratory markers, with a high probability of developing thrombotic complications, especially in conditions of deficiency of such minerals as zinc, selenium, iron, copper, bismuth, and aluminum, which have immunoregulatory, antioxidant, antiviral, and hemostatic properties, as well as reduce the risk of secondary infection. Conclusions. The results of the study suggest the importance of using minerals and emphasize the significance of using minerals in patients at the very beginning of the disease in order to strengthen the main physiological systems in case of laboratory-confirmed deficiency.

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Zinc status improving as a pathogenetically grounded platform for maintaining immunity during SARS-CoV-2 pandemic

Cited by 2 publications

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Biologically active food components as an element in the prevention of coronavirus infection: A review

Biologically active food components as an element in the prevention of coronavirus infection: A review

Features of hemostasis in patients after severe Covid-19 at discharge from the hospital (original study)

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