2019
DOI: 10.1007/s12274-019-2452-2
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Zinc-substituted hemoglobin with specific drug binding sites and fatty acid resistance ability for enhanced photodynamic therapy

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Cited by 17 publications
(17 citation statements)
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“…In this work 89 Zr was used as a radiolabel to monitor the in vivo biodistribution of human Hb injected in mouse models by PET/CT. Hb has recently moved to the center stage of biomedicine as a potential carrier of drugs [3,4,26,27]; it can be readily obtained either directly from patients or as a highly purified biopharmaceutical protein, it is biocompatible, non-antigenic, it undergoes naturally controlled degradation processes, it is amenable to genetic or chemical modifications and it shows unique pharmacokinetic properties [3,4,28,29]. We employed chemically modified Hb with maleimide-deferoxamine as a chelating agent for 89 Zr.…”
Section: Discussionmentioning
confidence: 99%
“…In this work 89 Zr was used as a radiolabel to monitor the in vivo biodistribution of human Hb injected in mouse models by PET/CT. Hb has recently moved to the center stage of biomedicine as a potential carrier of drugs [3,4,26,27]; it can be readily obtained either directly from patients or as a highly purified biopharmaceutical protein, it is biocompatible, non-antigenic, it undergoes naturally controlled degradation processes, it is amenable to genetic or chemical modifications and it shows unique pharmacokinetic properties [3,4,28,29]. We employed chemically modified Hb with maleimide-deferoxamine as a chelating agent for 89 Zr.…”
Section: Discussionmentioning
confidence: 99%
“…However, porphyrins in their original forms generally have poor photodynamic activity, hence PDT systems mostly uses porphyrin derivatives, which could have higher efficiency, as the photosensitizer [39] . For example, chlorophyll and heme are widely used in PDT, since both are endogenous products of natural organisms with superior biocompatibility and high efficiency [40] . Below, we will review various strategies to further improve clinical performance of porphyrin-based PDTs such as using modified porphyrin derivatives or porphyrin precursors, designing specific delivery vehicle, and applying combined therapies.…”
Section: Porphyrin and Porphyrin Derivativesmentioning
confidence: 99%
“…159 In view of this, Tan's group developed a folate acid (FA) modified, zinc-substituted hemoglobin as a photosensitizer (ZnPHb-FA) for PDT. 160 To develop this nanoplatform, hemin, or Fe protoporphyrin (FePPIX) in human hemoglobin was replaced with ZnPPIX, then the modified hemoglobin (ZnPHb) was decorated with FA, a tumor-targeting ligand (Figure 8e). Due to the inhibitory effect of ZnPHb against HO-1 and the photosensitizing capability of porphyrins, this protein-based nanoagent enabled enhanced photodynamic effect by lowering antioxidant defense (Figure 8f).…”
Section: Barriers To Pdtmentioning
confidence: 99%
“…(f) Schematic illustrates the anticancer mechanism of ZnPHb-FA nanoparticles. Modified and adapted with permission from ref . Copyright 2019, Springer Nature.…”
Section: Multifunctional Nanoassemblies For Enhanced Pdtmentioning
confidence: 99%
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