Zinc Supplementation Alleviates Lipid and Glucose Metabolic Disorders Induced by a High-Fat Diet

Qi, Yilin; Zhang, Zhiwang; Liu, Siqi; Aluo, Zhier; Zhang, Lifang; Lin, Yongcheng; Li, Yixing; Song, Ziyi; Zhou, Lei

doi:10.1021/acs.jafc.0c01103

Cited by 61 publications

(40 citation statements)

References 34 publications

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“…Triglyceride content was tested by a tissue/cell triglyceride (TG) kit ( 16 , 17 ) (Pulilai, Beijing, China). Briefly, tissue (0.1 g) was placed in a centrifuge tube, 1 ml RIPA lysis solution (Solarbio, Beijing, China) was added and steel balls were used to grind with a tissue grinder.…”

Section: Methodsmentioning

confidence: 99%

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Lipidomic and Transcriptomic Analysis of the Longissimus Muscle of Luchuan and Duroc Pigs

et al. 2021

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Meat is an essential food, and pork is the largest consumer meat product in China and the world. Intramuscular fat has always been the basis for people to select and judge meat products. Therefore, we selected the Duroc, a western lean pig breed, and the Luchuan, a Chinese obese pig breed, as models, and used the longissimus dorsi muscle for lipidomics testing and transcriptomics sequencing. The purpose of the study was to determine the differences in intramuscular fat between the two breeds and identify the reasons for the differences. We found that the intramuscular fat content of Luchuan pigs was significantly higher than that of Duroc pigs. The triglycerides and diglycerides related to flavor were higher in Luchuan pigs compared to Duroc pigs. This phenotype may be caused by the difference in the expression of key genes in the glycerolipid metabolism signaling pathway.

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Section: Methodsmentioning

confidence: 99%

“…Samples were then lysed overnight on a shaker. The lysate was centrifuged at 12,000 RPM for 10 min at 4°C, the supernatant was collected and TG and protein content was measured ( 16 ) by microplate reader (Tecan infinite M200 PRO). The TG level was normalized to the protein concentration.…”

Section: Methodsmentioning

confidence: 99%

Lipidomic and Transcriptomic Analysis of the Longissimus Muscle of Luchuan and Duroc Pigs

et al. 2021

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“…Eight-week-old male C57BL/6 mice were purchased from Guangxi Medical University (Naning, China) and resided in a standard laboratory environment with room temperature of 22 ± 1 °C and 12/12 h light/dark cycle ( 26 ). Drinking water is sterilized and accessible.…”

Section: Methodsmentioning

confidence: 99%

Integrated Transcriptomic and Translatomic Inquiry of the Role of Betaine on Lipid Metabolic Dysregulation Induced by a High-Fat Diet

et al. 2021

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An excessive high-fat/energy diet is a major cause of obesity and linked complications, such as non-alcoholic fatty liver disease (NAFLD). Betaine has been shown to effectively improve hepatic lipid metabolism. However, the mechanistic basis for this improvement is largely unknown. Herein, integration of mRNA sequencing and ribosome footprints profiling (Ribo-seq) was used to investigate the means by which betaine alleviates liver lipid metabolic disorders induced by a high-fat diet. For the transcriptome, gene set enrichment analysis demonstrated betaine to reduce liver steatosis by up-regulation of fatty acid beta oxidation, lipid oxidation, and fatty acid catabolic processes. For the translatome, 574 differentially expressed genes were identified, 17 of which were associated with the NAFLD pathway. By combined analysis of transcriptome and translatome, we found that betaine had the greater effect on NAFLD at the translational level. Further, betaine decreased translational efficiency (TE) for IDI1, CYP51A1, TM7SF2, and APOA4, which are related to lipid biosynthesis. In summary, this study demonstrated betaine alleviating lipid metabolic dysfunction at the translational level. The transcriptome and translatome data integration approach used herein provides for a new understanding of the means by which to treat NAFLD.

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Section: Animal Studiesmentioning

confidence: 99%

“…Some animal studies have revealed the beneficial effect of zinc supplementation on metabolic abnormality in the pre-diabetic and diabetic states 65,66) . Zinc supplementation for 14 weeks attenuated glucose and lipid metabolic abnormalities in mice fed with a high-fat diet 65) . In addition, dietary zinc supplementation for 6 weeks attenuated hyperglycemia and hyperinsulinemia in type 2 diabetic db/db mice 66) .…”

Section: Animal Studiesmentioning

confidence: 99%

The Role of Zinc Homeostasis in the Prevention of Diabetes Mellitus and Cardiovascular Diseases

Tamura

2021

JAT

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Zinc is an essential micronutrient for human health and is involved in various biological functions, such as growth, metabolism, and immune function. In recent years, research on intracellular zinc dynamics has progressed, and it has become clear that zinc transporters strictly control intracellular zinc localization, zinc regulates the functions of various proteins and signal transduction pathways as a second messenger similar to calcium ions, and intracellular zinc dyshomeostasis is associated with impaired insulin synthesis, secretion, sensitivity, lipid metabolism, and vascular function. Numerous animal and human studies have shown that zinc deficiency may be associated with the risk factors for diabetes and cardiovascular diseases (CVDs) and zinc administration might be beneficial for the prevention and treatment of these diseases. Therefore, an understanding of zinc biology may help the establishment of novel strategies for the prevention and treatment of diabetes and CVDs. This review will summarize the current knowledge on the role of zinc homeostasis in the pathogenesis of diabetes and atherosclerosis and will discuss the potential of zinc in the prevention of these diseases.in the skin and liver, and the remaining 2%-3% is in all the other tissues, including blood and blood vessels. Zinc deficiency is well known to be involved in various disorders in the whole-body, such as growth failure, immune disorders, and dysgeusia 5) . Furthermore, zinc deficiency also increases the risk for diabetes and CVDs 6, 7) . Recent findings have shown that intracellular zinc homeostasis regulated by zinc transporters is involved in the regulation of insulin synthesis, secretion, sensitivity, and vascular function 6,8) . This review will discuss the role of impaired intracellular zinc homeostasis in the pathogenesis of diabetes and atherosclerosis and whether zinc supplementation is beneficial for the prevention of these diseases. Intracellular Zinc HomeostasisZinc is a divalent cation and can bind to ~10% of all proteins found in the human body and functionsCopyright©2021 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.

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Zinc Supplementation Alleviates Lipid and Glucose Metabolic Disorders Induced by a High-Fat Diet

Cited by 61 publications

References 34 publications

Lipidomic and Transcriptomic Analysis of the Longissimus Muscle of Luchuan and Duroc Pigs

Lipidomic and Transcriptomic Analysis of the Longissimus Muscle of Luchuan and Duroc Pigs

Integrated Transcriptomic and Translatomic Inquiry of the Role of Betaine on Lipid Metabolic Dysregulation Induced by a High-Fat Diet

The Role of Zinc Homeostasis in the Prevention of Diabetes Mellitus and Cardiovascular Diseases

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