Zincuria and zincemia in postmenopausal osteoporosis

Contreras, Freddy; Simonovis, Nelson; Fouillioux, Christian; Bolívar, A; Cevallos, José Luis; Lezama, E; Velasco, Manuel

doi:10.1016/s0531-5131(01)00588-x

Cited by 9 publications

(7 citation statements)

References 11 publications

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“…Two studies [20,21] reported that serum Mg in osteoporotic women were significantly lower than the value in matched normal subjects. Conversely, Steidl et al [17] found a significant decrease in erythrocyte Mg content in patients with postmenopausal and senile osteoporosis but not in their serum levels.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, several studies found that serum Zn and Cu levels were lower among patients with postmenopausal osteoporosis than controls [ 17 - 19 ]. A relationship exists between the excretion of Zn in 24-hour urine and the appearance of osteoporosis, and the urinary Zn/creatinine relationship is a factor to take in mind in the osteoporosis [ 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…The indicators of discrepancy and accuracy of Zincuria are highly indicative of the value of this parameter as biochemical markers of bone resorption for the diagnosis of osteoporosis [ 15 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

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Association of Zinc, Copper and Magnesium with bone mineral density in Iranian postmenopausal women – a case control study

Razmandeh

Nasli‐Esfahani

Heydarpour

et al. 2014

J Diabetes Metab Disord

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BackgroundThe risk of inadequate nutrition such as trace elements and vitamin deficiencies is considerable in postmenopausal women. The aim of this study was to compare trace elements (Zinc, Copper and Magnesium) concentration in nail, urine and serum among osteoporotic postmenopausal women with control group in Iran.MethodsForty eight postmenopausal women aged 36–60 years, were recruited, consisting 30 osteoporotic patients and 18 healthy controls. Blood, nail and urine concentration of Zinc (Zn), copper (Cu) and magnesium (Mg) were determined using Inductively Coupled Plasma -Atomic Emission Spectrometry (ICP-AES) method. Their Bone Mineral Density was measured by Dual X-ray Absorption (DEXA) method.ResultsThe urine level of trace elements had significant difference between osteoporotic groups and controls (p < 0.001). Moreover Mg level significantly differed in serum between two groups (p < 0.04). There was no statistically significant difference in trace minerals in nail beyond groups.ConclusionOur findings indicate that Urine Zn level could be considerable an appropriate marker for bone absorption, usage of Zn supplements in postmenopausal women may result a beneficial reduction in osteoporotic risk.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association of Zinc, Copper and Magnesium with bone mineral density in Iranian postmenopausal women – a case control study

Razmandeh

Nasli‐Esfahani

Heydarpour

et al. 2014

J Diabetes Metab Disord

View full text Add to dashboard Cite

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“…It was noted in a study including menopausal women that urinary zinc discharge increased in the menopausal period, and that there was a significant relation between osteoporosis and zinc, as well as zinc and calcium [5]. It was concluded in the concerned study that determination of zinc levels could be a significant criterion in the diagnosis of osteoporosis [5]. In a study conducted on rats in which diabetes was induced by streptozotocin and which were fed on a zinc-deficient diet, zinc deficiency elevated calcium-phosphorus discharge significantly, relative to diabetic rats fed on a normal diet, and parallel to this, it was observed that bone damage in the former was more pronounced than that in the diabetic controls.…”

mentioning

confidence: 99%

“…It was shown that zinc functioned as a co-factor of specific enzymes in the bone metabolism, and that zinc supplementation increased spinal bone mineral density in menopausal women [4]. It was noted in a study including menopausal women that urinary zinc discharge increased in the menopausal period, and that there was a significant relation between osteoporosis and zinc, as well as zinc and calcium [5]. It was concluded in the concerned study that determination of zinc levels could be a significant criterion in the diagnosis of osteoporosis [5].…”

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confidence: 99%

The Effect of Low Dose Zinc Supplementation to Serum Estrogen and Progesterone Levels in Post-menopausal Women

Sunar

Gormus

Baltacı

et al. 2008

Biol Trace Elem Res

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The objective of the present study is to investigate how low-dose zinc supplementation for 2 weeks in the post-menopausal period influences levels of estrogen and progesterone in the serum. The study registered 32 natural menopause patients, who were allocated to four groups with equal number of patients. Group 1, control group, which was not subjected to any procedure. Group 2, the group that was supplemented with 15 mg/day zinc sulfate for 2 weeks. Group 3, the group that was given hormone replacement therapy (0.625 mg estrogen + 5 mg medroxyprogesterone acetate/day) for 2 weeks. Group 4, the group that received hormone replacement therapy (0.625 mg estrogen + 5 mg medroxyprogesterone acetate/day) and zinc sulfate (15 mg/day) for 2 weeks. Blood samples were collected twice from each subject, once at the beginning of the study, and once at the end of the 4-week procedure to determine estrogen (E2) and progesterone levels. Variance analysis was employed in the statistical evaluation of data. Level of significance was set at p < 0.05. No significant difference was found between the estrogen and progesterone levels of groups 1 and 2. Groups 3 and 4 had higher estrogen and progesterone levels than groups 1 and 2 (p < 0.05). Estrogen and progesterone levels in groups 3 and 4 were not different. Results of the study show that low-dose zinc supplementation to post-menopausal women for 2 weeks does not have a significant effect on the concerned parameters.

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PIXE study on the effects of parathyroid hormone on elemental content in rat bones

et al. 2016

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Zincuria and zincemia in postmenopausal osteoporosis

Cited by 9 publications

References 11 publications

Association of Zinc, Copper and Magnesium with bone mineral density in Iranian postmenopausal women – a case control study

Association of Zinc, Copper and Magnesium with bone mineral density in Iranian postmenopausal women – a case control study

The Effect of Low Dose Zinc Supplementation to Serum Estrogen and Progesterone Levels in Post-menopausal Women

PIXE study on the effects of parathyroid hormone on elemental content in rat bones

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