Zingerone induced caspase‐dependent apoptosis in MCF‐7 cells and prevents 7,12‐dimethylbenz(a)anthracene‐induced mammary carcinogenesis in experimental rats

Gan, Hong-Yun; Zhang, Yaqing; Zhou, Qingyun; Zheng, Lierui; Xie, Xiaofeng; Veeraraghavan, Vishnu Priya; Mohan, Surapaneni Krishna

doi:10.1002/jbt.22387

Cited by 58 publications

(31 citation statements)

References 43 publications

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“…Apoptosis is an important negative growth regulatory mechanism in tumors ( 25 ). In some malignancies, the apoptotic index may reflect the degree of carcinogenicity ( 26 ). Bcl-2 is a potent inhibitor of apoptosis and increases proliferation ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

SNHG1 promotes proliferation, migration and invasion of bladder cancer cells via the PI3K/AKT signaling pathway

Chen

2020

Exp Ther Med

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Long non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) has been previously reported to mediate a number of functions during the progression of cancer. However, its involvement in bladder cancer remain unclear. The aim of the present study was to investigate the expression of SNHG1 in bladder cancer and to identify its potential mechanisms. SNHG1 expression was firstly detected in cancer tissues and cells. The effects of SNHG1 on the malignant phenotypes were then investigated. Furthermore, the influence of SNHG1 on the PI3K/AKT signaling pathway was examined. It was demonstrated that SNHG1 expression was significantly upregulated in bladder cancer tissues and cells. Moreover, the loss-of-function experimental results suggested that knockdown of SNHG1 inhibited bladder cancer cell proliferation, migration and invasion, but increased apoptosis; however, SNHG1 overexpression promoted these processes. Mechanistically, rescue assays identified that SNHG1 activated the PI3K/AKT signaling pathway. Therefore, it was speculated that SNHG1 functioned as a carcinogenic lncRNA in bladder cancer via activation of PI3K/AKT.

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Section: Discussionmentioning

confidence: 99%

SNHG1 promotes proliferation, migration and invasion of bladder cancer cells via the PI3K/AKT signaling pathway

Chen

2020

Exp Ther Med

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“…Globally, breast cancer is becoming a principal cause of morbidity and mortality; however its impact is even more signi icant in developing countries (Gan et al, 2019). Studies proved that diabetic women are more prone to post-menopausal breast cancer than non-diabetic older women (Ponnulakshmi et al, 2019).…”

Section: Level Of Immunotherapies In Engineered Cell Therapiesmentioning

confidence: 99%

Engineered Cell Based Therapeutics

Kallivayalil¹,

S²,

Vishnupriya³

et al. 2020

ijrps

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Engineered cell-based therapeutics is having a great commitment in the field of treatment of human diseases. Scientific studies revealed that cell-based therapeutics play a key role in the treatment of cancers which can be an alternative for traditional immunotherapy. Even though there have been promising results, and the potential side effects resulting in mortality forced the scientists to impart regulations in the current therapies. These are evident in the growing frame of the literature of synthetic biology. Synthetic Biology empowered these new approaches to several applications in the medical field, including the development of bioengineered cell-based immunotherapies, peculiarly T-cell engineering with tumour-targeting receptors and the Chimeric Antigen Receptor (CAR)-T cells. The specific applications of this bioengineering of cells include direct injection of cells, merging the cells with a biomaterial scaffold in an in vitro or situ condition, or the biomaterial scaffold implantation alone which can induce surrounding cells leading to tissue restoration. Hence the aim of this review article is to highlight the various aspects of engineered cell-based therapeutics.

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“…Physical inactivity considerably contributes to obesity, which increases the risk for various lifestyle diseases like diabetes, cardiovascular diseases, cancers etc. (Ponnulakshmi et al, 2019;Gan, 2019). Thyroid cancer is the most widespread endocrine malignant cancer (Ma, 2019).…”

Section: Introductionmentioning

confidence: 99%

Awareness Of Risk Factors Associated With Obesity Among Homemakers

Begum

Kavitha

Sridevi

et al. 2020

ijrps

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Obesity is a condition in which excess body fat has accumulated to the extent that it may have an adverse effect on health. There are many reasons why a person becomes obese, and in case of homemakers, the main cause of obesity can be their sleeping habits, or the type of food they eat regularly, or lack of physical exercises. There are many risk factors of obesity which the homemakers should be aware of to reduce the chances of obesity and keep their lives healthy. The aim of the study was to create awareness on risk factors of obesity among homemakers. A questionnaire was prepared and circulated via an online platform. The data were collected, tabulated and analysed using SPSS software. Descriptive analysis and chi-square association test was performed. According to the results observed, an average of 83% of the participants is aware of the risk factors of obesity. 75.6% of the participants are aware that obesity causes heart diseases and digestive problems. The conclusion is that the majority of the homemakers are aware of the risk factors of obesity.

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Zingerone induced caspase‐dependent apoptosis in MCF‐7 cells and prevents 7,12‐dimethylbenz(a)anthracene‐induced mammary carcinogenesis in experimental rats

Cited by 58 publications

References 43 publications

SNHG1 promotes proliferation, migration and invasion of bladder cancer cells via the PI3K/AKT signaling pathway

SNHG1 promotes proliferation, migration and invasion of bladder cancer cells via the PI3K/AKT signaling pathway

Engineered Cell Based Therapeutics

Awareness Of Risk Factors Associated With Obesity Among Homemakers

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