Zingiber officinale Extract (ZOE) Incorporated with Layered Double Hydroxide Hybrid through Reconstruction to Preserve Antioxidant Activity of ZOE against Ultrasound and Microwave Irradiation

Kim, Hyoung-Jun; Lee, Su-Bin; Choi, Ae-Jin

doi:10.3390/nano9091281

Cited by 13 publications

(4 citation statements)

References 43 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As displayed in Figure 3 a, AH-1 had irregularly shaped particles of which the size was less than 100 nm. Compared with the other three samples, AH-1 did not show clear grain boundaries, which might be attributed to the large lumps of organic moiety [ 53 , 58 , 59 ] like proteins. After calcination (AO-1), particle morphology of ruffled layers appeared along with the combustion of albumin-template ( Figure 3 b).…”

Section: Resultsmentioning

confidence: 82%

Development of Mesopore Structure of Mixed Metal Oxide through Albumin-Templated Coprecipitation and Reconstruction of Layered Double Hydroxide

Jung

Kim

2021

Nanomaterials

Self Cite

View full text Add to dashboard Cite

Mixed metal oxide (MMO) with relatively homogeneous mesopores was successfully obtained by calcination and reconstruction of albumin-templated layered double hydroxide (LDH). The aggregation degree of albumin-template was controlled by adjusting two different synthesis routes, coprecipitation and reconstruction. X-ray diffraction patterns and scanning electron microscopic images indicated that crystal growth of LDH was fairly limited during albumin-templated coprecipitation due to the aggregation. On the hand, crystal growth along the lateral direction was facilitated in albumin-templated reconstruction due to the homogeneous distribution of proteins moiety. Different state of albumin during LDH synthesis influenced the local disorder and porous structure of calcination product, MMO. The N2 adsorption-desorption isotherms demonstrated that calcination on reconstructed LDH produced MMO with large specific surface area and narrow distribution of mesopores compared with calcination of coprecipitated LDH.

show abstract

Section: Resultsmentioning

confidence: 82%

Development of Mesopore Structure of Mixed Metal Oxide through Albumin-Templated Coprecipitation and Reconstruction of Layered Double Hydroxide

Jung

Kim

2021

Nanomaterials

Self Cite

View full text Add to dashboard Cite

show abstract

“…As indicated in the open circle curve in Figure 3 A, the average zeta potential of MTX-LDH at neutral pH was 4.61 ± 0.97 mV, showing almost neutral surface charge. Generally, the zeta potential of LDH at neutral pH is very positive, ~+30 mV [ 3 , 55 , 56 , 57 , 58 ], due to the strong positive charge density of LDH layers. However, the zeta potential drops to the neutral value region due to the MTX moieties, which were mostly intercalated into LDH but partially covered the outer surface of LDH layers [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

Physicochemical Properties and Hematocompatibility of Layered Double Hydroxide-Based Anticancer Drug Methotrexate Delivery System

et al. 2020

Self Cite

View full text Add to dashboard Cite

A layered double hydroxide (LDH)-based anticancer delivery system was investigated in terms of crystalline phase, particle size, hydrodynamic radius, zeta potential, etc. through in vitro and in vivo study. Size controlled LDH with anticancer drug methotrexate (MTX) incorporation was successfully prepared through step-by-step hydrothermal reaction and ion-exchange reaction. The MTX-LDH was determined to have a neutral surface charge and strong agglomeration in the neutral aqueous condition due to the surface adsorbed MTX; however, the existence of proteins in the media dramatically reduced agglomeration, resulting in the hydrodynamic radius of MTX-LDH being similar to the primary particle size. The protein fluorescence quenching assay exhibited that MTX readily reduced the fluorescence of proteins, suggesting that the interaction between MTX and proteins was strong. On the other hand, MTX-LDH showed much less binding constant to proteins compared with MTX, implying that the protein interaction of MTX was effectively blocked by the LDH carrier. The in vivo hemolysis assay after intravenous injection of MTX-LDH showed neither significant reduction in red blood cell number nor membrane damage. Furthermore, the morphology of red blood cells in a mouse model did not change upon MTX-LDH injection. Scanning electron microscopy showed that the MTX-LDH particles were attached on the blood cells without serious denaturation of cellular morphology, taking advantage of the cell hitchhiking property.

show abstract

“…An et al found that microwave drying of Zingiber officinale rhizome resulted in a decrease in TPC and had almost no effect on antioxidant potential compared to fresh ginger extract (DPPH, FRAP, ABTS tests) [103]. On the other hand, Kim et al, studying the effect of microwave radiation on the antioxidant activity of ginger rhizome extract, noticed a negative effect of this type of treatment (DPPH test) [104]. Interestingly, these results are opposite to the results obtained in the current study for the Alpinia rhizome, which revealed that subjecting the rhizome to microwave processing (regardless of the processing time) had a significant positive effect on TPC and antioxidant activity measured using DPPH assay.…”

Section: Discussionmentioning

confidence: 99%

Influence of Thermal Treatment on the Composition of Alpinia officinarum Rhizome

Zagórska,

Pietrzak,

Kukula-Koch

et al. 2024

IJMS

View full text Add to dashboard Cite

Alpinia officinarum is a representative of the Zingiberaceae family, which is known for its wide use in the food and pharmaceutical industries also due to its precious pharmacological potential. The major aim of the present study was to evaluate the influence of thermal treatment on the composition of the rhizome of Alpinia officinarum and its antioxidant activity. The fresh rhizome was subjected to various thermal treatment processes—boiling, frying and microwave heating during various time intervals—and their composition and antioxidant activity were determined using chromatographic (HPLC – High Performance Liquid Chromatography and HPLC-MS - High Performance Liquid Chromatography Mass Spectrometry) and spectrophotometric (DPPH and TPC – Total Phenolic Content) methods. Pinobanksin was the main compound found in the extract of the fresh rhizome (537.79 mg/kg), followed by galangin (197.7 mg/kg) and zingerone (185.5 mg/kg). The effect of thermal treatment on the rhizome composition was varied. In general, thermal processing significantly decreased the content of active compounds in the rhizome. However, there were some exceptions—boiling for 4 min significantly increased the content of pinobanksin (1162.4 mg/kg) and galangin (280.7 mg/kg), and microwave processing for 4 min increased the content of pinocembrin (213 mg/kg). It was found that boiling and microwave treatment significantly increased the antioxidant activity of the processed rhizomes.

show abstract

Zingiber officinale Extract (ZOE) Incorporated with Layered Double Hydroxide Hybrid through Reconstruction to Preserve Antioxidant Activity of ZOE against Ultrasound and Microwave Irradiation

Cited by 13 publications

References 43 publications

Development of Mesopore Structure of Mixed Metal Oxide through Albumin-Templated Coprecipitation and Reconstruction of Layered Double Hydroxide

Development of Mesopore Structure of Mixed Metal Oxide through Albumin-Templated Coprecipitation and Reconstruction of Layered Double Hydroxide

Physicochemical Properties and Hematocompatibility of Layered Double Hydroxide-Based Anticancer Drug Methotrexate Delivery System

Influence of Thermal Treatment on the Composition of Alpinia officinarum Rhizome

Contact Info

Product

Resources

About