Zingiber officinale Roscoe essential oil: An alternative strategy in the development of novel antimicrobial agents against MDR bacteria

Vaz, Márcia Soares Mattos; Simionatto, Euclésio; Souza, Gleyce de Almeida de Hellen; Fraga, Thiago Leite; Oliveira, Gustavo Gomes de; Coutinho, Eduardo João; Santos, Maiara Viviane Oliveira dos; Simionatto, Simone

doi:10.1016/j.indcrop.2022.115065

Cited by 13 publications

(5 citation statements)

References 22 publications

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“…Fresh animal dung and manure have been identified as a primary cause of AMR. Living (resistant) bacteria, free bacterial DNA, and antimicrobial resistance genes (ARG) are transmitted through the air as dust particles (Figure 2) (Dohmen et al, 2017;Laube et al, 2013;McEachran et al, 2015;von Salviati et al, 2015).…”

Section: Antimicrobials Resistance Rates In Animal Husbandrymentioning

confidence: 99%

An overview of the role of Zingiber officinale as an antimicrobial resistance (AMR) solution and a source of antioxidants

et al. 2023

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In this review, we describe the known mechanisms of antimicrobial resistance which was increasing in this era, due to the misuse of antimicrobial agents such as antibiotics, or genetic and phenotypic mechanisms. In this review, the concerns, especially addressed by designated researchers in their study and WHO in their observations and reports, regarding the types or strains of bacteria with antimicrobial resistances were described. In addition, the predicted mechanisms that promote the development and occurrence of antimicrobial resistances, such as bacterial biofilm formation, horizontal gene transfer, genetic mutations, free DNA which contains antimicrobial resistance genes, plasmids transfer through transformation or conjugation from bacterial cell to cell were well described. In addition, we also tried to describe the use of Z. officinale. The antimicrobial capabilities of this herbal plant are attributed to its capacity to create many secondary metabolites with rather complicated structures that have antibacterial and antioxidant characteristics. Z. officinale had been used for many kinds of diseases treatment traditionally. And along the way, the advance techniques of research in chemistry and biology fields had found out the composition and bioactive compound. In this review, the common online databases such as PubMed, Semantic Scholar, Crossref, Medline, Scopus, and Web of Science (WoS) were utilized to conduct literature searches. According to recent progress of antimicrobial cases observed, the efforts to strengthen the surveillance, general health systems, tightened the antimicrobial medicine distribution rules, and education for public are indeed needed.

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Section: Antimicrobials Resistance Rates In Animal Husbandrymentioning

confidence: 99%

An overview of the role of Zingiber officinale as an antimicrobial resistance (AMR) solution and a source of antioxidants

et al. 2023

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“…Recently, secondary plant metabolites have been used for the management of MDR pathogens. A study reported that the secondary plant metabolites like geranial, neral, 1,8-cineole, camphene, β-phellandrene, and α-curcumene obtained from the essential oil of Zingiber officinale have significant antibacterial properties against 18 resistant pathogens with high efficacy against gram-negative MDR pathogens, like carbapenem-and polymyxin-resistant ten Klebsiella pneumoniae and Serratia marcescens [30]. In a carbapenem-resistant K. pneumonia-induced mice sepsis model, researchers exhibited a reduction of bacterial load and increase in survival time of infected animals without any toxicity to the host.…”

Section: Natural Productsmentioning

confidence: 99%

“…In a carbapenem-resistant K. pneumonia-induced mice sepsis model, researchers exhibited a reduction of bacterial load and increase in survival time of infected animals without any toxicity to the host. This efficacy might be due to the presence of major secondary metabolites, like geranial, neral, and 1,8-cineole [30].…”

Section: Natural Productsmentioning

confidence: 99%

Current Treatment Strategies Against Multidrug-Resistant Bacteria: A Review

et al. 2022

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There are several bacteria called superbugs that are resistant to multiple antibiotics which can be life threatening specially for critically ill and hospitalized patients. This article provides up-to-date treatment strategies employed against some major superbugs, like methicillin-resistant Staphylococcus aureus, carbapenem-resistant Enterobacteriaceae, vancomycin-resistant Enterococcus, multidrug-resistant Pseudomonas aeruginosa, and multidrug-resistant Escherichia coli. The pathogen-directed therapeutics decrease the toxicity of bacteria by altering their virulence factors by specific processes. On the other hand, the host-directed therapeutics limits these superbugs by modulating immune cells, enhancing host cell functions, and modifying disease pathology. Several new antibiotics against the global priority superbugs are coming to the market or are in the clinical development phase. Medicinal plants possessing potent secondary metabolites can play a key role in the treatment against these superbugs. Nanotechnology has also emerged as a promising option for combatting them. There is urgent need to continuously figure out the best possible treatment strategy against these superbugs as resistance can also be developed against the new and upcoming antibiotics in future. Rational use of antibiotics and maintenance of proper hygiene must be practiced among patients.

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“…Nesse contexto, alguns bioativos têm demonstrado potencial atividade antimicrobiana, a exemplo dos metabólitos secundários obtidos do óleo essencial de Zingiber officinale, os quais demonstraram significante atividade antibacteriana contra 18 patógenos resistentes, sendo maior a eficácia contra patógenos Gram-negativos MDR, tais como K. pneumoniae e Serratia marcescens resistentes a polimixina e carbapenêmicos (Vaz et al, 2022).…”

Section: Introductionunclassified

Avaliação in vitro da atividade antimicrobiana dos óleos essenciais de Mentha piperita e Citrus limon contra cepas patogênicas

Bomfim,

Queiroz,

Santos

2023

RSD

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A elevada prevalência de microrganismos resistentes aos antimicrobianos comumente utilizados na prática clínica tem impactado os serviços de saúde devido à redução das opções de tratamento para os pacientes. Dessa forma, pesquisas envolvendo a atividade antimicrobiana de óleos essenciais (OE) tem sido realizadas como possíveis alternativas terapêuticas. O objetivo deste trabalho foi revisar a literatura e determinar experimentalmente a atividade antimicrobiana dos OE de Mentha piperita e Citrus limon frente aos patógenos Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa e Candida albicans. A busca bibliográfica e a seleção de artigos científicos foram realizadas nas bases de dados Pubmed, Biblioteca Virtual em Saúde e Scielo, adaptando-se os indexadores para cada base. Foram selecionados artigos completos, de acesso livre e publicados entre 2016 e 2022. A atividade antimicrobiana foi avaliada a partir microrganismos referência através do método de disco-difusão em ágar conforme metodologias preconizadas pelo CLSI e BrCAST. A pesquisa bibliográfica resultou em 533 artigos, dos quais foram selecionados 25 para a análise. A avaliação do OE de M. piperita demonstrou atividade contra E. coli, S. aureus e C. albicans e o OE de C.limon apresentou atividade para C. albicans. Nenhum dos OE testados apresentou atividade contra P. aeruginosa. Os dados deste trabalho destacam o potencial destes OE frente a patógenos importantes para a saúde humana e sugere a necessidade de novos estudos frente a outros patógenos emergentes para a saúde pública, além de melhor compreender a sua aplicabilidade como alternativa natural e segura para o controle das infecções bacterianas e fúngicas.

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Zingiber officinale Roscoe essential oil: An alternative strategy in the development of novel antimicrobial agents against MDR bacteria

Cited by 13 publications

References 22 publications

An overview of the role of Zingiber officinale as an antimicrobial resistance (AMR) solution and a source of antioxidants

An overview of the role of Zingiber officinale as an antimicrobial resistance (AMR) solution and a source of antioxidants

Current Treatment Strategies Against Multidrug-Resistant Bacteria: A Review

Avaliação in vitro da atividade antimicrobiana dos óleos essenciais de Mentha piperita e Citrus limon contra cepas patogênicas

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