Zirconia reinforced bio-active glass coating by spray pyrolysis: Structure, surface topography, in-vitro biological evaluation and antibacterial activities

Bargavi, P.; Chitra, S.; Durgalakshmi, D.; Radha, G.; Balakumar, S.

doi:10.1016/j.mtcomm.2020.101253

Cited by 16 publications

(13 citation statements)

References 56 publications

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“…Depending on the solvent and deposition parameters, solid or molten metal moieties may vaporize upon approaching the substrate and then the coating may grow via a true chemical vapor deposition (CVD) reaction. Recently, the method has been used for the production of Zirconia-incorporated bioactive glass films on pure Ti substrates [100], thin oxide films [101] and ultra-porous HAp network on Ti alloy discs [102] by using flame spray pyrolysis. It is a one-range synthesis process with a high scalability and production rate that is capable of producing coatings of a wide range of material compositions on nonplanar implants.…”

Section: Chemical Methodsmentioning

confidence: 99%

“…Zirconia-incorporated bioactive glass films on pure Ti substrates Spray pyrolysis [100] Bioactive glass onto ultra-fine-grained Ti substrates Laser cladding [152] CaO-MgO-SiO2-based bioactive glass-ceramic on Ti6-Al-4V alloy Atmospheric plasma spraying [294] Bioactive glass nanorods of 45S5 integrated with rGO sheets Sol-gel deposition [299] Bioactive glass-rGO hybrid thin on TiO 2 nanotubes Electrophoretic deposition [300] Bioglass coatings reinforced with Ti on Ti substrate Laser Engineered Net Shaping (LENS) [301] Synthetic polymers…”

Section: Bioactive Glassesmentioning

confidence: 99%

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Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants

Nikolova

Apostolova

2022

Materials

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To fix the bone in orthopedics, it is almost always necessary to use implants. Metals provide the needed physical and mechanical properties for load-bearing applications. Although widely used as biomedical materials for the replacement of hard tissue, metallic implants still confront challenges, among which the foremost is their low biocompatibility. Some of them also suffer from excessive wear, low corrosion resistance, infections and shielding stress. To address these issues, various coatings have been applied to enhance their in vitro and in vivo performance. When merged with the beneficial properties of various bio-ceramic or polymer coatings remarkable bioactive, osteogenic, antibacterial, or biodegradable composite implants can be created. In this review, bioactive and high-performance coatings for metallic bone implants are systematically reviewed and their biocompatibility is discussed. Updates in coating materials and formulations for metallic implants, as well as their production routes, have been provided. The ways of improving the bioactive coating performance by incorporating bioactive moieties such as growth factors, osteogenic factors, immunomodulatory factors, antibiotics, or other drugs that are locally released in a controlled manner have also been addressed.

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Section: Chemical Methodsmentioning

confidence: 99%

Section: Bioactive Glassesmentioning

confidence: 99%

Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants

Nikolova

Apostolova

2022

Materials

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“…For PEEK there are studies that have reported a null hemolytic reaction [119], as well as other studies have made superficial modifications of this material, improving fibrinogen adsorption, inhibition of adhesion and activation of platelets, achieving better antithrombogenicity [120]. On the other hand, there are biocompatible and hemocompatible filters for blood filtration that use the biomaterials PEEK and CFR-PEEK, which indicates that this material does not present any risk when used in devices in contact with blood [121].…”

Section: Hemocompatibilitymentioning

confidence: 99%

Comparison of Material Properties for Dental Implants: Titanium, Polyetheretherketone, Zirconium and Silicon Nitride

et al. 2022

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This review article presents the biological and technological properties of biomaterials: titanium, polyetheretherketone, zirconium and Si3N4, focused on the application of dental implants. The methodology focused on examining different works related to the topics of biocompatibility, biofilm formation and adhesion properties, fibroblast proliferation, bone resorption, peri-implant infection, osseointegration, histology, cytotoxicity, toxicity, carcinogenicity, genotoxicity, hemocompatibility, vascularization, mechanical resistance and approval for use by the FDA. The results of the review show that all four biomaterials have favorable properties that can revolutionize implants, however, more studies are needed to confirm the results in the short and medium term. MethodologyThe methodology was focused on carrying out a review of articles related to the topics of biocompatibility, biofilm formation and adhesion properties, fibroblast proliferation, bone resorption, peri-implant infection, osseointegration, histology, cytotoxicity, toxicity, carcinogenicity, genotoxicity, hemocompatibility, vascularity, mechanical resistance and approval for use by the FDA; related in dental implants and materials Ti, PEEK, Zr and Si3N4.

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“…Interestingly, the glass containing 5 mol% Zr showed the highest ALP activity compared to the other BGs [ 198 ]. The non-cytotoxic effect of zirconium-doped bioactive glass (5–15 wt.% of nano ZrO 2 powder) as thin film coatings on Cp-Ti substrates has also been investigated on MG 63 osteoblast cells [ 200 ]. Moreover, a recent study reported the advantages of 13–93 bioactive glass doped with zirconium (2 mol%) and silver oxide.…”

Section: Bioactive Glasses Doped With Other Elementsmentioning

confidence: 99%

Bioactive glasses incorporating less-common ions to improve biological and physical properties

Pantulap

Arango‐Ospina

Boccaccını

2021

J Mater Sci: Mater Med

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Bioactive glasses (BGs) have been a focus of research for over five decades for several biomedical applications. Although their use in bone substitution and bone tissue regeneration has gained important attention, recent developments have also seen the expansion of BG applications to the field of soft tissue engineering. Hard and soft tissue repair therapies can benefit from the biological activity of metallic ions released from BGs. These metallic ions are incorporated in the BG network not only for their biological therapeutic effects but also in many cases for influencing the structure and processability of the glass and to impart extra functional properties. The “classical” elements in silicate BG compositions are silicon (Si), phosphorous (P), calcium (Ca), sodium (Na), and potassium (K). In addition, other well-recognized biologically active ions have been incorporated in BGs to provide osteogenic, angiogenic, anti-inflammatory, and antibacterial effects such as zinc (Zn), magnesium (Mg), silver (Ag), strontium (Sr), gallium (Ga), fluorine (F), iron (Fe), cobalt (Co), boron (B), lithium (Li), titanium (Ti), and copper (Cu). More recently, rare earth and other elements considered less common or, some of them, even “exotic” for biomedical applications, have found room as doping elements in BGs to enhance their biological and physical properties. For example, barium (Ba), bismuth (Bi), chlorine (Cl), chromium (Cr), dysprosium (Dy), europium (Eu), gadolinium (Gd), ytterbium (Yb), thulium (Tm), germanium (Ge), gold (Au), holmium (Ho), iodine (I), lanthanum (La), manganese (Mn), molybdenum (Mo), nickel (Ni), niobium (Nb), nitrogen (N), palladium (Pd), rubidium (Rb), samarium (Sm), selenium (Se), tantalum (Ta), tellurium (Te), terbium (Tb), erbium (Er), tin (Sn), tungsten (W), vanadium (V), yttrium (Y) as well as zirconium (Zr) have been included in BGs. These ions have been found to be particularly interesting for enhancing the biological performance of doped BGs in novel compositions for tissue repair (both hard and soft tissue) and for providing, in some cases, extra functionalities to the BG, for example fluorescence, luminescence, radiation shielding, anti-inflammatory, and antibacterial properties. This review summarizes the influence of incorporating such less-common elements in BGs with focus on tissue engineering applications, usually exploiting the bioactivity of the BG in combination with other functional properties imparted by the presence of the added elements.

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Zirconia reinforced bio-active glass coating by spray pyrolysis: Structure, surface topography, in-vitro biological evaluation and antibacterial activities

Cited by 16 publications

References 56 publications

Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants

Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants

Comparison of Material Properties for Dental Implants: Titanium, Polyetheretherketone, Zirconium and Silicon Nitride

Bioactive glasses incorporating less-common ions to improve biological and physical properties

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