Zirconium Oxide Nanoparticles Modified Carbon Paste Electrode for Simultaneous Voltammetric Determination of Mebendazole and Levamisole Hydrochloride in Pharmaceutical Formulation and Human Plasma

Abstract

A new, simple and highly sensitive electrochemical method based on zirconium oxide nanoparticles modified carbon paste electrode (2 % ZrO 2 /CPE) was used for simultaneous determination of anthelmintics drugs Mebendazole (MB) and Levamisole HCl (LV) in drug substance, dosage form and human plasma. Differential pulse (DPV) and square wave (SWV) voltammetric analysis were applied in Britton Robinson buffer (pH 6; 0.04 M) after optimization of different analytical parameters. The studied drugs were measured simultaneously at very low concentration of analytes resulting in two wellseparated peaks. The detection limits were found to be 0.01 and 0.62 μM for MB and LV, respectively, using DPV and 0.01 and 0.42 μM for MB and LV, respectively using SWV.

Facile utility of felumin, a biological dye for the first fluorimetric determination of l-tetramisole drug through an “on–off fluorescence” strategy

“…HPLC was used to quantify LTS alone 22,23 and in the presence of other drugs such as albendazole, 24 heparin and pentobarbital, 25 abamectin, 26 and thiabendazole. 27 Also, an electrophoretic technique 28,29 and electroanalytical approaches [30][31][32] have been applied for its determination. Spectroscopic techniques [33][34][35] (including extractive spectrophotometric, 34 and ultraviolet methods 36 ), luminescence, 37 and the atomic absorption spectrometric method 38 have also been used.…”

Zirconium Oxide Nanostructure Integrated Screen-Printed Mirabegron Voltammetric Sensors

“…[50][51][52][53][54][55] Among different metallic oxide nanoparticles, zirconium oxide nanoparticles (ZrO 2 NPs, zirconia) were selected as a promising electrode modifier for sensing of various pharmaceutical compounds. [56][57][58][59][60] In this study a ZrO 2 NPs/SPEs electrochemical sensor was developed for the sensitive differential pulse voltametric assaying of mirabegron in biological samples and pharmaceutical tablet formulations. ZrO 2 NPs are attached to the printing carbon ink to serve as catalysts to oxidize the MIR molecule in the acidic medium where sensing performance parameters are then evaluated.…”