ZiYinHuaTan Recipe Inhibits Cell Proliferation and Promotes Apoptosis in Gastric Cancer by Suppressing PI3K/AKT Pathway

Yu, Jiahui; Song, Shangjin; Jiao, Jing; Li, Xuan; Zhu, Hong-Jian; Xiu, Lijuan; Sun, Dawei; Li, Qi; Yue, Xiaoqiang

doi:10.1155/2020/2018162

Cited by 12 publications

(7 citation statements)

References 33 publications

(31 reference statements)

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“…This method can reduce the activity of gastric cancer cells in nude mice in vitro and in vivo, but this model can only treat one person at a time. Samples can be processed in batches using machine learning to achieve popularization effects [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Experimental Research on the Antitumor Effect of Human Gastric Cancer Cells Transplanted in Nude Mice Based on Deep Learning Combined with Spleen-Invigorating Chinese Medicine

Yuan

Zheng

2022

Computational and Mathematical Methods in Medicine

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Gastric cancer is still the fifth most common malignant tumor in the world and has the fourth highest mortality rate in the world. Gastric cancer is difficult to treat because of its unobvious onset, low resection rate, and rapid deterioration. Therefore, humans have been working hard to combat gastric cancer. At present, the most commonly used treatment method is radiotherapy. However, this method will damage the normal tissues of the irradiated area while treating malignant tumor cells. It not only has side effects of damage to the patient’s skin and mucous membranes but also needs high-rate radiotherapy and has high cost for chemotherapy. In order to solve these problems, it is necessary to find new treatment methods. This article proposes the use of Chinese medicine to invigorate the spleen to inhibit human gastric cancer cells. This article combines modern machine learning technology with traditional Chinese medicine and combines traditional Chinese medicine physiotherapy with Western medicine nude mouse transplantation experiments. The treatment of tumors in Chinese medicine is based on the theory of Chinese medicine and has different characteristics. Western medicine has the advantage of permanently injuring patients. The process of the experiment is to transplant human-derived gastric cancer cells into nude mice. After grouping treatments and obtaining comparative data, deep learning techniques are used to analyze the properties of Chinese medicines for strengthening the spleen and to compare the properties of Chinese medicines for strengthening the spleen. The experimental results showed that the tumor inhibition rate of mice using fluorouracil was 18%, the tumor inhibition rate of mice using low-dose Chinese medicine was 16%, and the tumor inhibition rate of mice using high-dose Chinese medicine reached 52%. 80 days after the experiment, the survival rate of mice using high-dose Chinese medicine is 100% higher than that of mice without treatment.

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Section: Introductionmentioning

confidence: 99%

Experimental Research on the Antitumor Effect of Human Gastric Cancer Cells Transplanted in Nude Mice Based on Deep Learning Combined with Spleen-Invigorating Chinese Medicine

Yuan

Zheng

2022

Computational and Mathematical Methods in Medicine

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“…Especially, they found that ZYHT may exert anti-cancer effect mainly through PI3K/AKT signaling pathway related with potential mechanism for proliferation and apoptosis. These results suggest that ZYHT can be used as a method for the treatment of developed gastric cancer [ 96 ]. Schematic diagram of anti-metastatic mechanisms of each herbal medicine in gastric cancer is elucidated in Figure 3 .…”

Section: Resultsmentioning

confidence: 99%

“…Especially, AF on colorectal cancer, JLC on gastric cancer and SN, RP, TIF on breast cancer showed the efficacy of arrest of cell cycle in the G2/M stage [ 63 , 93 , 120 , 125 , 127 ]. On the other hand, Jingfukang on lung cancer, ZJW on colorectal cancer, XTHW, ZYHT on gastric cancer and SCB on liver cancer presented the efficacy of arrest of cell cycle in (G0)/G1 stage [ 56 , 84 , 94 , 96 , 101 ]. In addition, all clinical studies have shown a significant increase in survival time in the group of metastatic cancer patients administered with herbal medicine.…”

Section: Discussionmentioning

confidence: 99%

Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery

et al. 2021

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Metastasis is the main cause of cancer-related death. Despite its high fatality, a comprehensive study that covers anti-metastasis of herbal medicines has not yet been conducted. The aim of this study is to investigate and assess the anti-metastatic efficacies of herbal medicines in the five major cancers, including lung, colorectal, gastric, liver, and breast cancers. We collected articles published within five years using PubMed, Google Scholar, and Web of Science with “cancer metastasis” and “herbal medicine” as keywords. Correspondingly, 16 lung cancer, 23 colorectal cancer, 10 gastric cancer, 10 liver cancer, and 18 breast cancer studies were systematically reviewed. The herbal medicines attenuated metastatic potential targeting various mechanisms such as epithelial mesenchymal transition (EMT), reactive oxygen species (ROS), and angiogenesis. Specifically, the drugs regulated metastasis related factors such as matrix metalloproteinase (MMP), serine-threonine protein kinase/extracellular regulated protein kinase (AKT/ERK), angiogenic factors, and chemokines. Overall, the present study is the first review, comprehensively investigating the anti-metastasis effect of herbal medicines on five major cancers, providing the experimental models, doses and durations, and mechanisms. Herbal medicines could be a potent candidate for anti-metastatic drugs.

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“…miR-489 functions as an oncogene can significantly promote GC cell (SGC7901 and MKN45) proliferation, invasion, and migration and effectively block the activation of PI3K/AKT pathway [ 26 ]. Yu et al found that Zi Yin Hua Tan (ZYHT) recipe could inhibit tumor growth and cell proliferation and promote apoptosis in gastric cancer by suppressing the PI3K/AKT pathway [ 27 ]. Liu et al confirmed that ginsenoside Rg3 (Rg3), an herbal medicine, also a component of SJZT, can ameliorate gastric precancerous lesions in Atp4a-/- mice via inhibition of glycolysis through the PI3K/AKT pathway [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

High-Throughput Sequencing Reveals the Differential MicroRNA Expression Profiles of Human Gastric Cancer SGC7901 Cell Xenograft Nude Mouse Models Treated with Traditional Chinese Medicine Si Jun Zi Tang Decoction

Guo

Miao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. The present study aimed to investigate the potential mechanism underlying the antitumor effect of Si Jun Zi Tang (SJZT) decoction on gastric cancer. Methods. Twelve human gastric cancer SGC7901 cell xenograft nude mouse models were established. The mice were randomly divided into the Model group and SJZT group. SJZT exerted significant antitumor effects after 21 days of decoction administration. High-throughput sequencing was used to analyze the microRNA (miRNA) expression profiles of tumor tissues. Bioinformatics analysis was performed to provide further information regarding the differentially expressed miRNAs. Five representative differentially expressed miRNAs and four predicted target genes were further validated using quantitative real-time reverse transcription PCR (qRT-PCR). Results. We identified 33 miRNAs that were differentially expressed in the SJZT group compared with the Model group. Among them, 32 miRNAs were upregulated and 1 miRNA was downregulated. Bioinformatic analysis showed that most of miRNAs acted as tumor suppressors and their target genes participated in multiple signaling pathways, including the PI3K/Akt signaling pathway, microRNAs in cancer, and Wnt signaling pathway. The qRT-PCR result confirmed that miR-223-3p, miR-205-5p, miR-147b-3p, and miR-223-5p were overexpressed and their respective paired target genes FUT9, POU2F1, MUC4, and RAB14 mRNA were obviously downregulated in the SJZT group compared with those in the Model group. Network analysis revealed that miR-223-3p and miR-205-5p shared two targets POU2F1 (encoding POU class 2 homeobox 1) and FUT9 (encoding fucosyltransferase 9), suggesting they have a common role in certain pathways. Conclusion. This study provided novel insights into the anticancer mechanism of SJZT against gastric cancer, which might be partly related to the modulation of miRNA expression and their target pathways in tumors.

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ZiYinHuaTan Recipe Inhibits Cell Proliferation and Promotes Apoptosis in Gastric Cancer by Suppressing PI3K/AKT Pathway

Cited by 12 publications

References 33 publications

Experimental Research on the Antitumor Effect of Human Gastric Cancer Cells Transplanted in Nude Mice Based on Deep Learning Combined with Spleen-Invigorating Chinese Medicine

Experimental Research on the Antitumor Effect of Human Gastric Cancer Cells Transplanted in Nude Mice Based on Deep Learning Combined with Spleen-Invigorating Chinese Medicine

Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery

High-Throughput Sequencing Reveals the Differential MicroRNA Expression Profiles of Human Gastric Cancer SGC7901 Cell Xenograft Nude Mouse Models Treated with Traditional Chinese Medicine Si Jun Zi Tang Decoction

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