Ziyuglycoside II induces caspases-dependent and caspases-independent apoptosis in human colon cancer cells

Lkhagvasuren, Khaliunaa; Kim, Jin‐Kyung

doi:10.1016/j.tiv.2019.04.028

Cited by 25 publications

(13 citation statements)

References 37 publications

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“…Dihydrotanshinone I (DHTS) displayed both ROS-mediated apoptosis and autophagy in HCT116 cells as well as in HCT116 xenograft setting that was developed in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice [ 223 ]. Meanwhile, ziyuglycoside II, a major bioactive compound, revealed an altered production of ROS followed by both caspase-dependent and independent apoptosis in HCT116 cells [ 242 ]. Avenanthramide A induced ROS-mediated apoptosis by inhibiting the expression of DDX3, an RNA helicase in HCT116 and DLD-1 cells.…”

Section: Targeting Redox Alterations In Crcmentioning

confidence: 99%

The Role of Oxidative Stress and Its Counteractive Utility in Colorectal Cancer (CRC)

Basak

Uddin

Hancock

2020

Cancers

130

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An altered redox status accompanied by an elevated generation of reactive oxygen/nitrogen species (ROS/RNS) has been implicated in a number of diseases including colorectal cancer (CRC). CRC, being one of the most common cancers worldwide, has been reported to be associated with multiple environmental and lifestyle factors (e.g., dietary habits, obesity, and physical inactivity) and harboring heightened oxidative stress that results in genomic instability. Although under normal condition ROS regulate many signal transduction pathways including cell proliferation and survival, overwhelming of the antioxidant capacity due to metabolic abnormalities and oncogenic signaling leads to a redox adaptation response that imparts drug resistance. Nevertheless, excessive reliance on elevated production of ROS makes the tumor cells increasingly vulnerable to further ROS insults, and the abolition of such drug resistance through redox perturbation could be instrumental to preferentially eliminate them. The goal of this review is to demonstrate the evidence that links redox stress to the development of CRC and assimilate the most up-to-date information that would facilitate future investigation on CRC-associated redox biology. Concomitantly, we argue that the exploitation of this distinct biochemical property of CRC cells might offer a fresh avenue to effectively eradicate these cells.

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Section: Targeting Redox Alterations In Crcmentioning

confidence: 99%

The Role of Oxidative Stress and Its Counteractive Utility in Colorectal Cancer (CRC)

Basak

Uddin

Hancock

2020

Cancers

130

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“…According to Liu et al (2016), root extracts from S. officinalis increased apoptotic effects of 5-fluorouracil against two colorectal cancer cell lines (HCT-116 and RKO), a synergistic action that was attributed to the presence of phenolic compounds such as gallic, catechin and ellagic acid. Other authors suggested ziyuglycoside II or polysaccharide fractions as the main bioactive compounds of S. officinalis with several health effects and significant antioxidant capacity (Lkhagvasuren & Kim, 2019;Zhang et al, 2012;Zhu et al, 2013). These results highlight the need for further research to corroborate the associations of health effects with specific compounds as well as to elucidate the mechanisms behind these activities.…”

Section: Cytotoxic Activitymentioning

confidence: 99%

“…In particular, in the recent study of Tan et al (2019) it was reported that both the S. officinalis extracts and ellagic acid obtained after purification of plant extracts possess anticancer activity through the antiproliferation action against B16F10 melanoma cells. Moreover, ziyuglycoside II, the main phytochemical isolated from S. officinalis roots, exhibited anticancer activity by inducing apoptosis of HCT116 and SW480 human colon cancer cells (Lkhagvasuren & Kim, 2019). Moreover, S. minor exhibited significant antioxidant activity which was correlated with the increased content in total phenolic compounds (Romojaro, Sanchez-Bel, Serrano, & Pretel, 2013), while Romojaro et al (2013) suggested the incorporation of S. minor leaves in vegetable oils as a means to increase their overall oxidative stability.…”

Section: Introductionmentioning

confidence: 98%

“…(small burnet) and Sanguisorba officinalis L. (great burnet) which are native in the Mediterranean basin and other areas of the world (Gawron-Gzella et al, 2016;Karkanis et al, 2019). The leaves and roots of these species contain a wide variety of bioactive compounds such as gallic acid, ellagic acid, (+)-catechin, lambertianin C, sanguiin H-10, and ziyuglycoside II (Karkanis et al, 2019;Lkhagvasuren & Kim, 2019;Tan et al, 2019;Zhu et al, 2019). So far, it has been well documented that isolated bioactive compounds and/or extracts of both species exert a broad spectrum of medicinal properties.…”

Section: Introductionmentioning

confidence: 99%

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Bioactive properties of Sanguisorba minor L. cultivated in central Greece under different fertilization regimes

et al. 2020

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In this study, the chemical characterization and bioactive properties of S. minor cultivated under different fertilization rates (control, half rate and full rate) were evaluated. Twenty-two phenolic compounds were identified, including five phenolic acids, seven flavonoids and ten tannins. Hydrolysable tannins were prevalent, namely Sanguiin H-10, especially in leaves without fertilization (control). Roots of full-rate fertilizer (660 Kg/ha) presented the highest flavonoid content, mainly catechin and its isomers, whereas half-rate fertilizer (330 Kg/ha), presented the highest content of total phenolic compounds, due to the higher amount of ellagitannins (lambertianin C: 84 ± 1 mg/g of dry extract). Antimicrobial activities were also promising, especially against Salmonella typhimurium (MBC = 0.44 mg/mL). Moreover, root samples revealed activity against all tested cell lines regardless of fertilization rate, whereas leaves were effective only against HeLa cell line. In conclusion, S. minor could be a source of natural bioactive compounds, while fertilization could increase phenolic compounds content.

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“…Apoptosis is a complex process in which various protein signals are transmitted through several different pathways (25). Caspases, which are the convergence points of multiple apoptotic pathways, regulate the final execution of apoptosis (26,27). Thus, caspase activation is an essential link in apoptotic signal transduction (28).…”

Section: Daphnoretin Exerts Antitumor Effects In Specific Tumor Typesmentioning

confidence: 99%

Daphnoretin induces reactive oxygen species‑mediated apoptosis in melanoma cells

Wang

Pan

et al. 2021

Oncol Lett

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Research suggests that daphnoretin exhibits a diverse array of antitumor mechanisms and pharmacological activities. However, there is no definitive explanation for the antitumor mechanisms of daphnoretin in malignant melanoma. In the present study, MTT and colony formation assays demonstrated that daphnoretin significantly inhibited the proliferation of melanoma A375 and B16 cells. Following treatment with daphnoretin, apoptotic bodies were observed in A375 and B16 cells via Hoechst 33258 staining. Furthermore, western blot analysis revealed that the apoptosis-related proteins cleaved caspase-3, cleaved caspase-9, Bax, cytochrome c and apoptotic protease-activating factor 1 were significantly upregulated, while the expression levels of caspase-3, caspase-9 and Bcl-2 were downregulated in A375 and B16 cells. Flow cytometry and fluorescence microscopy revealed that daphnoretin induced higher levels of reactive oxygen species (ROS). Therefore, the results of the present study indicated that daphnoretin induced ROS-mediated mitochondria apoptosis in human (A375) and murine (B16) malignant melanoma cells.

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Ziyuglycoside II induces caspases-dependent and caspases-independent apoptosis in human colon cancer cells

Cited by 25 publications

References 37 publications

The Role of Oxidative Stress and Its Counteractive Utility in Colorectal Cancer (CRC)

The Role of Oxidative Stress and Its Counteractive Utility in Colorectal Cancer (CRC)

Bioactive properties of Sanguisorba minor L. cultivated in central Greece under different fertilization regimes

Daphnoretin induces reactive oxygen species‑mediated apoptosis in melanoma cells

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