Zn(OAc)2•2H2O-catalyzed green synthesis of substituted 1-amido/thioamidoalkyl-2-naphthols

,; TOTAWAR, Pradeep Rameshrao; VARALA, Ravi; ,; PULLE, Jitendra S.; ,

doi:10.33224/rrch.2023.68.1-2.07

Rev.Roum.Chim.

2023

DOI: 10.33224/rrch.2023.68.1-2.07

|View full text |Cite

Zn(OAc)2•2H2O-catalyzed green synthesis of substituted 1-amido/thioamidoalkyl-2-naphthols

Pradeep Rameshrao TOTAWAR,

Ravi VARALA,

Jitendra S. PULLE

Abstract: Zn(OAc)2.2H2O (5 mol%)-catalyzed one-pot multicomponent reaction of β-napthol, aldehydes and amide/thioamides to produce corresponding amidobenzylnaphthols in shorter reaction times (20 min-2 h) under neat conditions at 70 oC, is reported in good to excellent yields (58-95%).

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

One-Pot, Three-Component Coupling Synthesis of [(Benzothiazol-2-ylamino)(aryl)methyl]isoquinolinols under Catalyst- and Solvent-Free Conditions

Hawsawi,

Gandhamsetty,

Alluhaibi

2024

Synlett

View full text Add to dashboard Cite

One-pot three-component coupling procedure has been developed for the synthesis of (2'-aminobenzothiazolomethyl-aryl)-hydroxyisoquinolines via the reaction of hydroxyisoquinolines, aryl/heteroaryl/aliphatic aldehydes with 2-aminobenzothiazoles under catalyst- and solvent-free conditions. The developed 2'-aminobenzothiazolomethylation procedure is suitable to execute even on gram scale with a broad scope. The 2'-aminobenzothiazolomethylated products (Betti bases) were formed through the initial nucleophilic C-attack of hydroxyisoquinolines on aldehydes to generate the ortho-Quinone Methide (o-QM) as an intermediate followed by the subsequent 1,4-aza-Michael addition of 2-aminobenzothiazoles. Betti bases have significance in medicinal chemistry due to their wide range of pharmacological applications and they are useful ligands and catalysts in asymmetric synthesis.

show abstract

One-Pot, Three-Component Coupling Synthesis of [(Benzothiazol-2-ylamino)(aryl)methyl]isoquinolinols under Catalyst- and Solvent-Free Conditions

Hawsawi,

Gandhamsetty,

Alluhaibi

2024

Synlett

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Zn(OAc)2•2H2O-catalyzed green synthesis of substituted 1-amido/thioamidoalkyl-2-naphthols

Abstract: Zn(OAc)2.2H2O (5 mol%)-catalyzed one-pot multicomponent reaction of β-napthol, aldehydes and amide/thioamides to produce corresponding amidobenzylnaphthols in shorter reaction times (20 min-2 h) under neat conditions at 70 oC, is reported in good to excellent yields (58-95%).

Cited by 1 publication

References 50 publications

One-Pot, Three-Component Coupling Synthesis of [(Benzothiazol-2-ylamino)(aryl)methyl]isoquinolinols under Catalyst- and Solvent-Free Conditions

One-Pot, Three-Component Coupling Synthesis of [(Benzothiazol-2-ylamino)(aryl)methyl]isoquinolinols under Catalyst- and Solvent-Free Conditions

Contact Info

Product

Resources

About