ZNF606 interacts with Sox9 to regulate chondrocyte differentiation

Zhou, Zhenhai; Yu, Honggui; Wang, Yunjia; Guo, Qiang; Wang, Longjie; Zhang, Hongqi

doi:10.1016/j.bbrc.2016.09.048

Biochemical and Biophysical Research Communications

2016

DOI: 10.1016/j.bbrc.2016.09.048

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ZNF606 interacts with Sox9 to regulate chondrocyte differentiation

Zhenhai Zhou

Honggui Yu

Yunjia Wang

et al.

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Cited by 4 publications

(1 citation statement)

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“…The rs8107849 locus does not lie in iPSC or heart-related chromHMM regulatory regions and was not identified in our analysis as a nondynamic eQTL at any time point. Although ZNF606 is known to have a role in differentiation of chondrocytes (22), it is possible this is a conserved process involved in the differentiation of additional cell types, including cardiomyocytes. Another nonlinear dynamic eQTL reveals an association between rs28818910 and C15orf39.…”

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confidence: 99%

Dynamic genetic regulation of gene expression during cellular differentiation

Strober

Elorbany

Rhodes

et al. 2019

Science

184

165

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Genetic regulation of gene expression is dynamic, as transcription can change during cell differentiation and across cell types. We mapped expression quantitative trait loci (eQTLs) throughout differentiation to elucidate the dynamics of genetic effects on cell type specific gene expression. We generated time-series RNA-sequencing data, capturing 16 time points from induced pluripotent stem cells to cardiomyocytes, in 19 human cell lines. We identified hundreds of dynamic eQTLs that change over time, with enrichment in enhancers of relevant cell types. We also found nonlinear dynamic eQTLs, which affect only intermediate stages of differentiation, and cannot be found by using data from mature tissues. These fleeting genetic associations with gene regulation may represent a new mechanism to explain complex traits and disease. We highlight one example of a nonlinear eQTL that is associated with body mass index.

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confidence: 99%

Dynamic genetic regulation of gene expression during cellular differentiation

Strober

Elorbany

Rhodes

et al. 2019

Science

184

165

View full text Add to dashboard Cite

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Association of expression of ZNF606 gene from monocytes with the risk of coronary artery disease

Guo

Wang

Liu³

et al. 2018

Clinical Biochemistry

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Effect of quercetin on chondrocyte phenotype and extracellular matrix expression

Gui

Zhou

et al. 2020

Chinese Journal of Natural Medicines

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ZNF606 interacts with Sox9 to regulate chondrocyte differentiation

Cited by 4 publications

References 20 publications

Dynamic genetic regulation of gene expression during cellular differentiation

Dynamic genetic regulation of gene expression during cellular differentiation

Association of expression of ZNF606 gene from monocytes with the risk of coronary artery disease

Effect of quercetin on chondrocyte phenotype and extracellular matrix expression

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