2020
DOI: 10.5603/fhc.a2020.0026
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ZNF750 inhibits the proliferation and invasion of melanoma cells through modulating the Wnt/b-catenin signaling pathway

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Cited by 6 publications
(7 citation statements)
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“…GRLH3 is a member of the grainyhead family of transcription factors and a low expression of this protein has been described in nonmelanoma skin tumors [17]. Another relevant gene in Molecular 1 group is ZNF750: its overexpression decreases proliferation of melanoma cells, whereas its depletion causes opposite effects [18].Molecular 1 comprised most of primary tumors included in the TCGA and GEM cohorts. The group showed higher activity of the nodes "epidermis development" and "keratin".…”
Section: Discussionmentioning
confidence: 99%
“…GRLH3 is a member of the grainyhead family of transcription factors and a low expression of this protein has been described in nonmelanoma skin tumors [17]. Another relevant gene in Molecular 1 group is ZNF750: its overexpression decreases proliferation of melanoma cells, whereas its depletion causes opposite effects [18].Molecular 1 comprised most of primary tumors included in the TCGA and GEM cohorts. The group showed higher activity of the nodes "epidermis development" and "keratin".…”
Section: Discussionmentioning
confidence: 99%
“…3A), DQF-COSY and E-COSY experiments, together with natural abundance 13 C-HSQC (Fig. 3B) and 15 N-sofast HMQC (Fig. 3C) spectra.…”
Section: Z* Has a Typical Znf Bba Foldmentioning
confidence: 99%
“…Both samples had a measured pH of 5.9. The experiments recorded on the H2O sample included 70 ms mixing time TOCSY (mlevgpphw5), 200 ms mixing time NOESY (noesygpphw5), and a natural abundance 15 Nsofast-HMQC (sfhmqcf3gpph). The names in parentheses are the Bruker pulse programs for the experiments.…”
Section: Nmr Spectroscopymentioning
confidence: 99%
See 1 more Smart Citation
“… 6 Evidence from melanocyte development indicate the possibility that WNT/β-catenin signaling orchestrates melanoma progression by regulating cell proliferation and invasion and modulating the immune microenvironment. 7 , 8 An increasing level of nuclear β-catenin has been shown to play a critical role in melanoma during disease progression. 9 , 10 In actively proliferating melanoma cells, nuclear β-catenin triggers the expression of microphthalmia-associated transcription factor that in turn activates the transcription of several downstream genes including VEGF.…”
Section: Introductionmentioning
confidence: 99%