ZnO Doped Nanosized Composite Material Based on Hydroxyapatite and Sodium Alginate Matrix

Pogrebnjak, A.D.; Sukhodub, L. F.; Бондар, О. В.; Turlybekuly, Amanzhol

doi:10.1007/978-981-13-6133-3_35

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…The dispersion of HA in the alginate solution under the influence of ultrasound followed by crosslinking with Ag + ions makes significant changes in the microstructure of the HA-Alg-Ag composite. Electron microscopic studies show a pronounced contour of the particles, characteristic of similar biocomposites with a matrix of sodium alginate (Pogrebnjak et al 2019b, Turlybekuly et al 2019, Sukhodub et al 2020. The Ca/P weight ratio for these samples is around 1.71 ± 0.10 (0.125 Ag) to 1.73 ± 0.11 (0.25 Ag).…”

Section: Resultsmentioning

confidence: 93%

“…The IR spectra of the HA-0.2Ag and HA-2.0Ag samples contain bands characteristic of HA: ν (OH) at 3570 cm −1 and the peak at 960 cm −1 corresponding to the P-O symmetric stretching mode (ν1) of the PO 4 group (figures 6 (a) and (b)) (Turlybekuly et al 2018). The peak at 1032 cm −1 should be attributed to the asymmetric stretching mode (ν3) of the P-O bond and bending vibrations of PO 4 groups: 602 and 562 cm −1 (Rajkumar et al 2011).…”

Section: Resultsmentioning

confidence: 99%

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Antibacterial and physical characteristics of silver-loaded hydroxyapatite/alginate composites

Sukhodub¹,

Sukhodub²,

Pogrebnjak³

et al. 2021

Funct. Compos. Struct.

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The influence of silver ions on antibacterial properties and morphology of Hydroxyapatite-Ag (HА-Ag) and Hydroxyapatite-Alginate-Ag (HA-Alg-Ag) nanocomposites was studied. The microstructure and phase composition of the obtained nanocomposites were investigated by SEM, TEM, XRD, FTIR methods, and the formation of the crystalline phase of Ag3PO4 was proved. According to the results, silver ions were incorporated into the HA structure, partially replacing calcium ions. The antimicrobial activity assessment was carried out on Gram-negative (Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus) test cultures by the co-incubation and modified «agar diffusion» methods. We have demonstrated that antimicrobial and adhesive properties of both Ag-HA and HA-Alg-Ag are strongly affected by the crystal lattice structure, controlled by silver ions location. The composite materials could be of great interest in the biomedical field, including the design of coatings that prevent or lag the bacterial biofilm development.

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Antibacterial and physical characteristics of silver-loaded hydroxyapatite/alginate composites

Sukhodub¹,

Sukhodub²,

Pogrebnjak³

et al. 2021

Funct. Compos. Struct.

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show abstract

“…One methodology to improve the bioactivity is to enrich the implant surface with elements such as calcium and phosphorus. Materials based on calcium and phosphates can provide additional stimulation for osteogenic cell adhesion and proliferation [27][28][29]. Different amorphous, hydroxyapatite and brushite coatings encourage osteoblast adhesion, alkaline phosphatase (ALP) and collagen synthesis and enhance MSC differentiation [30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of electrochemically bioactivated Ti6Al4V 3D porous scaffolds

Myakinin

Turlybekuly

Pogrebnjak

et al. 2021

Materials Science and Engineering: C

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Triply periodic minimal surfaces (TPMS) are known for their advanced mechanical properties and are wrinkle-free with a smooth local topology. These surfaces provide suitable conditions for cell attachment and proliferation. In this study, the in vitro osteoinductive and antibacterial properties of scaffolds with different minimal pore diameters and architectures were investigated. For the first time, scaffolds with TPMS architecture were treated electrochemically by plasma electrolytic oxidation (PEO) with and without silver nanoparticles (AgNPs) to enhance the surface bioactivity. It was found that the scaffold architecture had a greater impact on the osteoblast cell activity than the pore size. Through control of the architecture type, the collagen production by osteoblast cells increased by 18.9% and by 43.0% in the case of additional surface PEO bioactivation. The manufactured scaffolds demonstrated an extremely low quasi-elastic modulus (comparable with trabecular and cortical bone), which was 5 -10 times lower than that of bulk titanium (6.4-11.4 GPa vs 100-105 GPa). The AgNPs provided antibacterial properties against both gram-positive and gram-negative bacteria and had no significant impact on the osteoblast cell growth. Complex experimental results show the in vitro effectiveness of the PEO-modified TPMS architecture, which could positively impact the clinical applications of porous bioactive implants.

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Effect of magnetic particles adding into nanostructured hydroxyapatite–alginate composites for orthopedics

Sukhodub

Pogrebnjak

et al. 2020

J. Korean Ceram. Soc.

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ZnO Doped Nanosized Composite Material Based on Hydroxyapatite and Sodium Alginate Matrix

Cited by 3 publications

References 33 publications

Antibacterial and physical characteristics of silver-loaded hydroxyapatite/alginate composites

Antibacterial and physical characteristics of silver-loaded hydroxyapatite/alginate composites

In vitro evaluation of electrochemically bioactivated Ti6Al4V 3D porous scaffolds

Effect of magnetic particles adding into nanostructured hydroxyapatite–alginate composites for orthopedics

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