ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting nuclear translocation of p-NFκB p65 and cysteine deficiency in keratinocytes

Lai, Xuan; Wang, Menglei; Zhu, Yixia; Feng, Xiaoli; Liu, Huimin; Wu, Junrong; Nie, Li; Li, Li; Shao, Longquan

doi:10.1016/j.jhazmat.2020.124566

Cited by 36 publications

(25 citation statements)

References 46 publications

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“…Zinc oxide (ZnO) has been of great interest because of its excellent physical properties, such as low cost, nontoxicity, high thermal stability, photosensitivity, advanced optical properties, and environmentally friendly features [5,6]. erefore, ZnO has been widely used in many fields, such as adsorption, paint, cosmetic, superconductor, and catalyst [7][8][9][10][11][12]. As an effective photocatalyst in the degradation of persistent organic compounds [13][14][15] and catalyst support [16,17], ZnO should have a sufficient structure area and morphology to allow the diffusion of active species and electron transfer [18].…”

Section: Introductionmentioning

confidence: 99%

Facile Controlling of the Physical Properties of Zinc Oxide and Its Application to Enhanced Photocatalysis

Pham

Mac

et al. 2021

Journal of Analytical Methods in Chemistry

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In this study, the physical properties of ZnO were facile controlled by the synthesis method with the addition of capping and precipitation agents. As-prepared ZnO samples had different morphologies such as carnation flower-like ZnO (CF-ZnO), rose-flower-like ZnO (RF-ZnO), rod-like ZnO (R-ZnO), and nanoparticle ZnO (N-ZnO) and were characterized by SEM, XRD, N2 adsorption/desorption isotherms, FT-IR, and DR/UV-vis. All samples had a crystallite structure of hexagonal wurtzite type. The CF-ZnO and RF-ZnO samples had the hierarchical structure like a carnation flower and a beautiful rose, respectively. R-ZnO was composed of many hexagonal rods and few spherical particles, while N-ZnO microstructures were made up of nanoparticles with approximately 20–30 nm, exhibiting the largest surface area, pore volume, and pore width among as-prepared samples, and their crystal size and bandgap energy were 17.8 nm and 3.207 eV, respectively. The catalytic performances of ZnO samples were evaluated by degradation of Tartrazine (TA) and Caffeine (CAF) under low UV irradiation (15 W). N-ZnO showed a high photocatalytic activity compared to other samples. Besides, the reaction kinetics was investigated by the first-order kinetic model, and the catalytic performance of ZnO was evaluated through several organic pollutants.

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Section: Introductionmentioning

confidence: 99%

Facile Controlling of the Physical Properties of Zinc Oxide and Its Application to Enhanced Photocatalysis

Pham

Mac

et al. 2021

Journal of Analytical Methods in Chemistry

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“…To prepare a suspension for use in animal experiments, ZnO NPs were dispersed in normal saline (NS) containing 1% hydroxypropyl methylcellulose (HPMC) [ 12 ] at a concentration of 40 mg/ml. HPMC was used as a suspending agent to ensure that the NPs were uniformly dispersed and to increase operability.…”

Section: Methodsmentioning

confidence: 99%

“…Reports have suggested that ZnO NPs in sunscreens can penetrate injured or diseased skin, such as skin with sunburn, acne, or eczema, and skin with psoriasis-like features [ 1 , 12 ]. Some studies have shown that NPs deposited in target organs can generate excessive oxidative stress, triggering injurious responses, such as apoptosis and DNA damage [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Continuous ZnO nanoparticle exposure induces melanoma-like skin lesions in epidermal barrier dysfunction model mice through anti-apoptotic effects mediated by the oxidative stress–activated NF-κB pathway

Wang

Zhang

et al. 2022

J Nanobiotechnol

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Background Increasing interest in the hazardous properties of zinc oxide nanoparticles (ZnO NPs), commonly used as ultraviolet filters in sunscreen, has driven efforts to study the percutaneous application of ZnO NPs to diseased skin; however, in-depth studies of toxic effects on melanocytes under conditions of epidermal barrier dysfunction remain lacking. Methods Epidermal barrier dysfunction model mice were continuously exposed to a ZnO NP-containing suspension for 14 and 49 consecutive days in vivo. Melanoma-like change and molecular mechanisms were also verified in human epidermal melanocytes treated with 5.0 µg/ml ZnO NPs for 72 h in vitro. Results ZnO NP application for 14 and 49 consecutive days induced melanoma-like skin lesions, supported by pigmented appearance, markedly increased number of melanocytes in the epidermis and dermis, increased cells with irregular nuclei in the epidermis, recruited dendritic cells in the dermis and dysregulated expression of melanoma-associated gene Fkbp51, Trim63 and Tsp 1. ZnO NPs increased oxidative injury, inhibited apoptosis, and increased nuclear factor kappa B (NF-κB) p65 and Bcl-2 expression in melanocytes of skin with epidermal barrier dysfunction after continuously treated for 14 and 49 days. Exposure to 5.0 µg/ml ZnO NPs for 72 h increased cell viability, decreased apoptosis, and increased Fkbp51 expression in melanocytes, consistent with histological observations in vivo. The oxidative stress–mediated mechanism underlying the induction of anti-apoptotic effects was verified using the reactive oxygen species scavenger N-acetylcysteine. Conclusions The entry of ZnO NPs into the stratum basale of skin with epidermal barrier dysfunction resulted in melanoma-like skin lesions and an anti-apoptotic effect induced by oxidative stress, activating the NF-κB pathway in melanocytes. Graphical Abstract

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“…For instance, carbon nanotubes and nickel NPs have been reported to cause skin hypersensitivity because of the ions released and surface coverings from NPs [142]. Research displayed that NP exposure to transdermal skin can exacerbate skin inflammation, irritation, and psoriasis [143,144]. Some studies also showed oxidative stress, autophagy, and programmed cell death in fibroblasts and keratinocytes when exposed to NPs [145].…”

Section: Limitations Of Nps In Wound Healingmentioning

confidence: 99%

Nanomaterial-Based Therapy for Wound Healing

2022

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Poor wound healing affects millions of people globally, resulting in increased mortality rates and associated expenses. The three major complications associated with wounds are: (i) the lack of an appropriate environment to enable the cell migration, proliferation, and angiogenesis; (ii) the microbial infection; (iii) unstable and protracted inflammation. Unfortunately, existing therapeutic methods have not solved these primary problems completely, and, thus, they have an inadequate medical accomplishment. Over the years, the integration of the remarkable properties of nanomaterials into wound healing has produced significant results. Nanomaterials can stimulate numerous cellular and molecular processes that aid in the wound microenvironment via antimicrobial, anti-inflammatory, and angiogenic effects, possibly changing the milieu from nonhealing to healing. The present article highlights the mechanism and pathophysiology of wound healing. Further, it discusses the current findings concerning the prospects and challenges of nanomaterial usage in the management of chronic wounds.

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ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting nuclear translocation of p-NFκB p65 and cysteine deficiency in keratinocytes

Cited by 36 publications

References 46 publications

Facile Controlling of the Physical Properties of Zinc Oxide and Its Application to Enhanced Photocatalysis

Facile Controlling of the Physical Properties of Zinc Oxide and Its Application to Enhanced Photocatalysis

Continuous ZnO nanoparticle exposure induces melanoma-like skin lesions in epidermal barrier dysfunction model mice through anti-apoptotic effects mediated by the oxidative stress–activated NF-κB pathway

Nanomaterial-Based Therapy for Wound Healing

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