Zonisamide for Attenuation of Weight Gain in a Morbidly-Obese Adolescent on an Antipsychotic

Abstract

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Zonisamide for Weight Loss in Adolescents

“…Since the time of an earlier literature review, 3 more data regarding the effect of zonisamide on weight loss has emerged. Yang et al 8 reported on 3 adult Korean patients with schizophrenia previously treated with antipsychotics who were then treated with zonisamide.…”

“…The definition of being overweight for a child (age [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] in the Unites States is a body mass index (BMI) between the 85th and 95th percentiles, and obesity is defined as at or above the 95th percentile. 1 The rate of obesity in children has tripled since 1980, 1 with the most recent data indicating that 16.9% of children fall into the obese range.…”

“…1 We previously documented a case of a 14-year-old adolescent male who lost nearly 100 kg (starting at 301 kg and ending at 202.76 kg) during a 3-month period during which he was in a pediatric hospital and an adolescent psychiatric unit. 3 This patient was treated with zonisamide for the sole purpose of weight loss. However, the 100-kg weight loss that resulted was confounded by several variables that could have influenced the outcome, including the added structure of the hospital and more proportioned meals compared to his usual home diet.…”