Zoonosis: An Emerging Link to Antibiotic Resistance Under “One Health Approach”

Dafale, Nishant A.; Srivastava, Shweta; Purohit, Hemant J.

doi:10.1007/s12088-020-00860-z

Cited by 96 publications

(71 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first one is the overuse of antibiotics, synthetic drugs, often veterinary drugs, which degrade very slowly in the environment. 13 Their persistence and presence in our daily food have significantly increased the speed at which resistances develop and spread in bacteria. 14,15 Second, the relation between AMR and healthcare-associated infections (also called hospital-acquired infections, HAIs) have been a serious public health problem since the uncontrolled use and commercialization of antibiotics started.…”

mentioning

confidence: 99%

“…[60][61][62] In AMPs, there is no precise rule about the ideal number of hydrophobic residues or charged residues to maximize antimicrobial activity, as this balance varies widely and appears to be associated with some form of selective activity. 45,59,63 Coil CTFTLPGGGGVCTLTSECIC (20) -1 45% Daptomycin 74,75 Coil WNDTGKDADGSEY (13) -3 15% Darobactin 52 Coil WNWSKSF (7) +1 42% a Cationic and hydrophobic amino acids. b Correspond to the amount of positively charged residues minus the amount of negatively charged residues.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Synthetic Polypeptide Polymers as Simplified Analogues of Antimicrobial Peptides

et al. 2020

View full text Add to dashboard Cite

Antimicrobial peptides (AMPs) are naturally occurring macromolecules made of amino acids that are potent broad-spectrum antibiotics with potential as novel therapeutic agents. This review aims to summarize the fundamental principles concerning the structure and mechanism of action of these AMPs, in order to guide the design of polymeric analogues that organic chemistry can generate. Among those simplified analogues, this review particularly focuses on those made of amino acids called polypeptide polymers: they are showing great potential by providing one of the best biomimetic and bioactive structures for further biomaterials science applications.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Synthetic Polypeptide Polymers as Simplified Analogues of Antimicrobial Peptides

et al. 2020

View full text Add to dashboard Cite

show abstract

“…“Animal to human” (and “human to animal”) transmission occurs from co-habiting, food production, and contact with animal feces. This interconnection of humans and animals via shared ecosystems and the food chain is now an area that is considered under the One Health approach [ 3 ]. Controlling animal disease and zoonotic pathogens is effective in controlling human disease, as seen with human brucellosis, which is reduced when controlled in the animal reservoir.…”

Section: One Healthmentioning

confidence: 99%

“…At present, 0.7 million people die annually from drug-resistant disease, with 230,000 deaths directly related to MDR tuberculosis (TB) alone. Indeed, the WHO reports that of the TB cases in 2014, an estimated 3.3 percent were multidrug resistant [ 3 ]. The public health cost of AMR, and in particular antibiotic resistance (ABR), is expected to be significant, with over 2 million people affected annually [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Bacteriophages and the One Health Approach to Combat Multidrug Resistance: Is This the Way?

Garvey

2020

Antibiotics

View full text Add to dashboard Cite

Antimicrobial resistance necessitates action to reduce and eliminate infectious disease, ensure animal and human health, and combat emerging diseases. Species such as Acinetobacter baumanniii, vancomycin resistant Enterococcus, methicillin resistance Staphylococcus aureus, and Pseudomonas aeruginosa, as well as other WHO priority pathogens, are becoming extremely difficult to treat. In 2017, the EU adopted the “one health” approach to combat antibiotic resistance in animal and human medicine and to prevent the transmission of zoonotic disease. As the current therapeutic agents become increasingly inadequate, there is a dire need to establish novel methods of treatment under this one health Framework. Bacteriophages (phages), viruses infecting bacterial species, demonstrate clear antimicrobial activity against an array of resistant species, with high levels of specificity and potency. Bacteriophages play key roles in bacterial evolution and are essential components of all ecosystems, including the human microbiome. Factors such are their specificity, potency, biocompatibility, and bactericidal activity make them desirable options as therapeutics. Issues remain, however, relating to their large-scale production, formulation, stability, and bacterial resistance, limiting their implementation globally. Phages used in therapy must be virulent, purified, and well characterized before administration. Clinical studies are warranted to assess the in vivo pharmacokinetics and pharmacodynamic characteristics of phages to fully establish their therapeutic potential.

show abstract

“…Furthermore, zoonotic diseases represent a persistent problem in livestock production and animal health (Rohr et al, 2019). Accordingly, diseases such as bovine tuberculosis (BTB) and brucellosis, are not eradicated from many countries, remaining as sanitary control diseases that harm production yields and inflict significant economic losses (Arenas and Moreno, 2016;Dafale et al, 2020). In this regard, low animal screening can delay effective epidemiologic surveillance of BTB and brucellosis, affecting food safety in the long-term.…”

Section: Introductionmentioning

confidence: 99%

Interactive web-based tool for evaluating the spread of bovine tuberculosis and brucellosis in Colombia

Arenas

Avila

Correa

et al. 2020

Rev. colomb. cienc. pecu.

View full text Add to dashboard Cite

Interactive web-based tool for evaluating the spread of bovine tuberculosis and brucellosis in Colombia This unedited manuscript has been accepted by RCCP for future publication and is provisionally published on our website. The manuscript will undergo copyediting, typesetting, and galley review before final publication. Please note that this advance version may differ from the "Ahead of print" and also from the final version. SHORT COMMUNICATION Interactive web-based tool for evaluating the spread of bovine tuberculosis and brucellosis in Colombia Herramienta interactiva basada en la web para evaluar la propagación de la tuberculosis bovina y la brucelosis en Colombia Ferramenta interativa baseada na web para avaliar a disseminação da tuberculose e brucelose bovina na Colômbia

show abstract

Zoonosis: An Emerging Link to Antibiotic Resistance Under “One Health Approach”

Cited by 96 publications

References 77 publications

Synthetic Polypeptide Polymers as Simplified Analogues of Antimicrobial Peptides

Synthetic Polypeptide Polymers as Simplified Analogues of Antimicrobial Peptides

Bacteriophages and the One Health Approach to Combat Multidrug Resistance: Is This the Way?

Interactive web-based tool for evaluating the spread of bovine tuberculosis and brucellosis in Colombia

Contact Info

Product

Resources

About