Objective. To identify differences in peripheral blood gene expression between patients with different subclasses of juvenile idiopathic arthritis (JIA) and healthy controls in a multicenter study of patients with recent-onset JIA prior to treatment with diseasemodifying antirheumatic drugs (DMARDs) or biologic agents. Results. A total of 9,501 differentially expressed probe sets were identified among the JIA subtypes and controls (by analysis of variance; false discovery rate 5%). Specifically, 193, 1,036, 873, and 7,595 probe sets were different in PBMCs from the controls compared with those from the ERA, persistent oligoarthritis, RF-negative polyarthritis, and systemic JIA patients, respectively. In patients with persistent oligoarthritis, RF-negative polyarthritis, and systemic JIA subtypes, up-regulation of genes associated with interleukin-10 (IL-10) signaling was prominent. A hemoglobin cluster was identified that was underexpressed in ERA patients but overexpressed in systemic JIA patients. The influence of JAK/STAT, ERK/MAPK, IL-2, and B cell receptor signaling pathways was evident in patients with persistent oligoarthritis. In systemic JIA, up-regulation of innate immune pathways, including IL-6, Toll-like receptor/IL-1 receptor, and peroxisome proliferatoractivated receptor signaling, were noted, along with down-regulation of gene networks related to natural killer cells and T cells. Complement and coagulation pathways were up-regulated in systemic JIA, with a subset of these genes being differentially expressed in other subtypes as well. Methods

Here we describe the Siding Spring Southern Seyfert Spectroscopic Snapshot Survey (S7) and present results on 64 galaxies drawn from the first data release. The S7 uses the Wide Field Spectrograph mounted on the ANU 2.3 m telescope located at the Siding Spring Observatory to deliver an integral field of 38 × 25 arcsec at a spectral resolution of R = 7000 in the red (530-710 nm), and R = 3000 in the blue (340-560 nm). From these data cubes we have extracted the narrow-line region spectra from a 4 arcsec aperture centered on the nucleus. We also determine the Hβ and [O III] λ5007 fluxes in the narrow lines, the nuclear reddening, the reddening-corrected relative intensities of the observed emission lines, and the Hβ and [O III] λ5007 luminosities determined from spectra for which the stellar continuum has been removed. We present a set of images of the galaxies in, and Hα, which serve to delineate the spatial extent of the extended narrow-line region and also to reveal the structure and morphology of the surrounding H II regions. Finally, we provide a preliminary discussion of those Seyfert 1 and Seyfert 2 galaxies that display coronal emission lines in order to explore the origin of these lines.

Objectives South Asians (individuals from India, Pakistan, Bangladesh, Nepal, and Sri Lanka) have high rates of cardiovascular disease which cannot be explained by traditional risk factors. Few studies have examined coronary artery calcium (CAC) in South Asians. Methods We created a community-based cohort of South Asians in the United States and compared the prevalence and distribution of CAC to four racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA). We compared 803 asymptomatic South Asians free of cardiovascular disease to the four MESA racial/ethnic groups (2,622 Whites, 1,893 African Americans, 1,496 Latinos and 803 Chinese Americans). Results The age-adjusted prevalence of any CAC was similar between White and South Asian men, but was lower in South Asian women compared to White women. After adjusting for all covariates associated with CAC, South Asian men were similar to White men and had higher CAC scores compared to African Americans, Latinos and Chinese Americans. In fully adjusted models, CAC scores were similar for South Asian women compared to all women enrolled in MESA. However, South Asian women ≥70 years had a higher prevalence of any CAC than most other racial/ethnic groups. Conclusions South Asian men have similarly high CAC burden as White men, but higher CAC than other racial/ethnic groups. South Asian women appear to have similar CAC burden compared to other women, but have somewhat higher CAC burden in older age. The high burden of subclinical coronary atherosclerosis in South Asians may partly explain higher rates of cardiovascular disease in South Asians.

The optical spectra of Seyfert galaxies are often dominated by emission lines excited by both star formation and AGN activity. Standard calibrations (such as for the star formation rate) are not applicable to such composite (mixed) spectra. In this paper, we describe how integral field data can be used to spectrally and spatially separate emission associated with star formation from emission associated with accretion onto an active galactic nucleus (AGN). We demonstrate our method using integral field data for two AGN host galaxies (NGC 5728 and NGC 7679) from the Siding Spring Southern Seyfert Spectroscopic Snapshot Survey (S7). The spectra of NGC 5728 and NGC 7679 form clear sequences of AGN fraction on standard emission line ratio diagnostic diagrams. We show that the emission line luminosities of the majority (> 85 per cent) of spectra along each AGN fraction sequence can be reproduced by linear superpositions of the emission line luminosities of one AGN dominated spectrum and one star formation dominated spectrum. We separate the Hα, Hβ, [N II]λ6583, [S II]λλ6716, 6731, [O III]λ5007 and [O II]λλ3726, 3729 luminosities of every spaxel into contributions from star formation and AGN activity. The decomposed emission line images are used to derive the star formation rates and AGN bolometric luminosities for NGC 5728 and NGC 7679. Our calculated values are mostly consistent with independent estimates from data at other wavelengths. The recovered star forming and AGN components also have distinct spatial distributions which trace structures seen in high resolution imaging of the galaxies, providing independent confirmation that our decomposition has been successful.

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