The analysis of the epizootic situation with rabies for the period 1999-2018 showed that 33079 animals suffered from rabies, 19687 (59.5%) of them were domesticated animals, 13392 (40.5%) were wild. The percentage of sick animals with the highest rates of morbidity from the total number of patients is: for cats-25.3%, for dogs-19.3%, for cattle-13%, for foxes-36.7%. The disease was registered in 10 species of domestic animals and 18 species of wild ones. Among wild animals, the highest incidence was recorded among foxes-12,136 animals or 90.6%, high incidence of rabiesraccoon dogs-507 or 3.78%, martens-363 or 2.7%, wolves-158 animals, or 1.17%. The study of seasonality for this disease showed the maximum manifestation in the autumn-winter period. All regions with a high tense of epizootic situation with rabies are interconnected (mainly the eastern, northern and central regions of Ukraine). The low tenseness of the epizootic situation is observed mainly in the western regions. During the analyzed period in Ukraine, 58 people died from rabies. The number of bites animals suspected of developing rabies disease was estimated from 879 (2016) to 3983 (2007). Such a large number of bites in 2007 is logical, since the number of sick animals in this period was the highest. Antirabies assistance needed 6,373 people (2014) up to 110 202 (2003).