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Antitussive Drugs—Past, Present, and Future

“…Evidence suggests that caramiphen exerts its antitussive effect centrally (Domino et al, 1985), although others have suggested it should be classified as a peripherally acting drug (Bolser et al, 1995a). Domenjoz (1952) found it equivalent to codeine in suppressing cough evoked by mechanical stimulation of rat trachea. Subsequent animal experiments confirmed this antitussive effect when caramiphen was administered intravenously (Toner and Macko, 1952;Chakravarty et al, 1956), although caramiphen was largely ineffective when administered orally (Stefko et al, 1961).…”

Action antitussive d’un hypnotique non barbiturique, la métolquizolone

“…1» Chez le Chat, nous utilisons une technique très voisine de celle pré conisée par Domenjoz (6). L'animal est anesthésie au mébuharbilal (50 mg./kg.…”

Observations on the Treatment of Rheumatoid Arthritis with Butazolidin

“…Anti-Inflammatory.-The anti-inflammatory effects of-Butazolidin on the oedema caused by the injection of (i) egg albumin, and (ii) formalin, into the legs of rats was studied by Domenjoz (1952), Theobald (cited by Domenjoz, 1952), and Wilhelmi (1949-52). They showed that the oedema-inhibiting effects of injecting subcutaneously 200 mg./kg.…”