Zur Behandlung der Keratitis dendritica mit para-Fluorphenylalanin

Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis

“…Healing curves (Graupner 1968; Wellings 1972) and survival analysis (Coster 1976; Coster 1979) are recommended for reporting treatment trials of HSV epithelial keratitis, but these analytical methods were unevenly applied. Nearly a third of otherwise eligible studies were not included in this review because of incompletely reported data.…”

“…Antiviral compounds emerged as potential treatments for herpetic keratitis during the last half of the 20 th century (Bauer 1985; Graupner 1969). In 1962 idoxuridine (iododeoxyuridine, IDU), a pyrimidine analogue, was the first effective antiherpetic drug (Kaufman 1962).…”

“…Corneal epithelial removal, usually by iodinisation or carbolisation, became a customary remedy for dendritic keratitis during the first half of the 20 th century. Initial clinical trials of corneal epithelial removal involved the application of noxious solutions such as tincture of iodine (Austin 1974; Davidson 1964; Graupner 1969; Matthäus 1970; Struck 1989) or phenol (Fulhorst 1972; MacKenzie 1964; Patterson 1967a; Patterson 1967b), sometimes in combination with mechanical scraping. Subsequent methods of corneal debridement included cryoapplication (Fulhorst 1972; Struck 1989), photoinactivation (Bartholomew 1977; Daniel 1972; O’Day 1975), and thermocautery (Sundmacher 1976a; Sundmacher 1976b; Sundmacher 1978a; Sundmacher 1978b).…”