Zur Differenzierung der Varianten 5-1 und 6-1 im Adenosindesaminase-Polymorphismus. Nachweis des neuen Phänotyps ADA 5-2 in der ČSSR

Enzyme Activity and Distribution of Adenosine Deaminase Types in a Population of Central Italy

“…The pattern is a combination of three enzyme bands pro duced by the ADA*1 allele with three more anodic bands produced by the ADA *5 allele. The finding of the ADA 5-1 phenotype in a mother and her son con firms the inheritance of this type previ ously shown by Radam et al [1975]. The 2 ADA 5-1 individuals did not seem to show any particular clinical symptoms.…”

ADA^7 - A New Allele

“…Subsequent ly, additional alleles have been observed which occur at very low frequen cies. These include the allele ADA3 of Hopkinson et al [5], the phenotype reported by Dissing and Knudsen [4], the allele ADA5 postulated by Detter et al [3] which was confirmed by Radam et al [7], the allele ADA6 of Radam et al [6],and the 'silent' allele ADA0 of Brinkmann et al [1] and Chen et al [2], Chen et al [2] demonstrated furthermore the association of a 'silent' gene at the ADA locus with combined immunodeficiency disease.…”

?New? phenotypes in the human red cell isozyme system ADA

“…They observed three phenotypes A D A 1, A D A 2-1, and A D A 2, which were controlled by two codominant alleles A D A * I and ADA*2. Subsequently, several rare variants were identified and shown by family studies to represent heterozygous combinations of either A D A * I or ADA*2 with a rare variant allele (ADA*3, ADA*4, ADA*5, ADA*6, or ADA*7) at the same locus [1,[4][5][6]10].…”