“…while even before the discovery of the sinu-atrial node (vide infra) experimental evidence had indicated that the impulse started at the site of entry of the right precaval vein into the right atrium (e.g. Krehl & Romberg, 1893 ;Hering, 1900Hering, ,1907Langendorff & Lehmann, 1906;Rehfisch, 1906). The sinu-atrial node was originally described by Keith & Flack (1907) as a mauI of peculiar inuscle fibres, some nerve cells and nerve fibres, embedded in densely packed epicardial connective tissue, and related mainly to the region of entry of the right precaval vein into the right atrium.…”