Zur Frage der Alters- und Diagnoseabhängigkeit der Links-Lateralisation und Lokalisation von EEG-Herden

Koufen, H; Gast, C.

doi:10.1007/bf00343808

Cited by 8 publications

(4 citation statements)

References 16 publications

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“…Firstly, we confirm earlier reports that interictal epileptiform patterns are more likely to be found only over the left cerebral hemisphere than only over the right [1‐6]. The inference from earlier reports was that the left hemisphere was the site of focal seizures more frequently than the right.…”

Section: Discussionsupporting

confidence: 90%

“…-Over the last several decades, reports haveappeared in the literaturethat indicate that focal epi leptiform patterns on electroencephalography (EEG) may be more likely to occur only over the left cerebral hemispherethan only over the right [1][2][3][4][5][6]. Such observations imply that the left brain may generate focal seizuresmore frequently than the right brain.…”

Section: Discussionmentioning

confidence: 99%

“…The concept that the left cerebral hemisphere is more predisposed than the right to damage is not new and is based mainly on the preponderance of interictal EEG abnormalities found over the left hemisphere in patients with epilepsy [1, 2, 4‐6].…”

Section: Discussionmentioning

confidence: 99%

“…Other reasonsmust be sought to account for the fact that the left hemisphere is more frequently dysfunctional than the right. The concept that the left cerebral hemisphere is more predisposed than the right to damage is not new and is based mainly on the preponderance of interictal EEG abnormalities found over the left hemisphere in patients with epilepsy [1,2,[4][5][6].…”

Section: Discussionmentioning

confidence: 99%

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Is the left cerebral hemisphere more prone to epileptogenesis than the right?

Holmes,

Dodrill,

Kutsy

et al. 2001

Epileptic Disorders

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Purpose To determine if there is evidence that the left cerebral hemisphere is more prone to epileptogenesis than the right hemisphere. Methods. We examined 532 patients with localization‐related epilepsy, as documented by long‐term EEG‐video monitor studies. We identified those with interictal epileptiform patterns on EEG confined to one hemisphere, those with clinical seizures that arose only from one side, and individuals with neuropsychological deficits lateralizing more to one cerebral hemisphere than the other. These data were then related to the handedness of the subjects. Results For left‐handed patients, interictal discharges were significantly more likely to be confined to the left side, seizures more frequently arose from only the left hemisphere, and neuropsychological deficits lateralized more often to the left brain. In contrast, for right‐handed subjects, there were no significant differences in unilateral localization of either interictal discharges or of seizure onsets, nor did neuropsychological deficits lateralize more often to one side or the other. Although, as a group, left‐handers had an earlier age of onset of epilepsy than right‐handers, the lateralizing EEG and neuropsychological patterns seen in left‐handers were not related to age of onset of epilepsy, febrile seizures, family history of either epilepsy or left‐handedness, or other risk factors. Conclusion In localization‐related epilepsy, there is a significant association of left‐handedness with left hemispheric lateralization of epileptiform EEG patterns and neuropsychological deficits. These findings do not clearly reflect a greater left than right cerebral hemispheric vulnerability to epileptogensis, except possibly in left‐handers.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Is the left cerebral hemisphere more prone to epileptogenesis than the right?

Holmes,

Dodrill,

Kutsy

et al. 2001

Epileptic Disorders

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Longitudinal¹H MRS assessment of the thalamus in a Coriaria lactone‐induced rhesus monkey status epilepticus model

Zhang

Yang

et al. 2012

NMR in Biomedicine

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Neurophysiological, biochemical and anatomical evidence implicates the thalamus as playing a role in epileptic seizures. Until recently, however, longitudinal characterization of in vivo thalamus dynamics had not been reported. In this study, we investigated the metabolism in the thalamus to identify the changes that occur following Coriaria lactone (CL)-induced status epilepticus (SE) and to observe whether the epileptiform discharges could present a difference between the left and right thalami. Five rhesus monkeys underwent whole-brain MRI and single-voxel MRS on a Siemens Trio Tim 3-T MR scanner with a 12-channel head coil. Spectra were processed using LCModel. Scans were performed in five animals before SE and at 1, 7, 21 and 42 days after the onset of SE. Statistical analysis of the data obtained demonstrated no significant difference in the bilateral thalamus of healthy macaques. Our MRS data showed symmetrical distributions of N-acetylaspartate in the right and left thalami after SE (p = 0.003). In addition, this longitudinal study demonstrated elevated glutamate/glutamine (p < 0.05) and reduced myo-inositol (p < 0.05) in the bilateral thalamus 1 day after SE, and all metabolites approached their baseline levels by the fifth scan. Our results demonstrate that metabolic changes occur in the thalamus during CL-induced SE in rhesus monkeys. The various metabolic changes may indicate that the left thalamus is more vulnerable to epileptic strike.

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The EEG in hypnosedative drug withdrawal and dependence

Sweden

1984

Eur Arch Psychiatr Neurol Sci

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Compulsive hypnosedative drug use is commonly associated with the development of tolerance and physical dependence. As most data are derived from human or animal experiments, electroclinical correlations in the clinical field are rather scarce. The informative value of the EEG features registered in 22 patients presenting minor and/or major signs of a clinical hypnosedative drug withdrawal syndrome are discussed. The electroclinical correlations are investigated and the physiopathogenesis of both clinical and EEG dysfunction are related to the neurochemical theory of dependence and withdrawal. It is suggested that the drug withdrawal syndrome represents a transient unbalanced metabolic state at the neuronal cellular level, which may be included among the causes of metabolic encephalopathies. The severity of this encephalopathy and the moment at which it occurs depend on both exogenous and personal factors.

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Zur Frage der Alters- und Diagnoseabhängigkeit der Links-Lateralisation und Lokalisation von EEG-Herden

Cited by 8 publications

References 16 publications

Is the left cerebral hemisphere more prone to epileptogenesis than the right?

Is the left cerebral hemisphere more prone to epileptogenesis than the right?

Longitudinal¹H MRS assessment of the thalamus in a Coriaria lactone‐induced rhesus monkey status epilepticus model

The EEG in hypnosedative drug withdrawal and dependence

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Zur Frage der Alters- und Diagnoseabhängigkeit der Links-Lateralisation und Lokalisation von EEG-Herden

Cited by 8 publications

References 16 publications

Is the left cerebral hemisphere more prone to epileptogenesis than the right?

Is the left cerebral hemisphere more prone to epileptogenesis than the right?

Longitudinal1H MRS assessment of the thalamus in a Coriaria lactone‐induced rhesus monkey status epilepticus model

The EEG in hypnosedative drug withdrawal and dependence

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Longitudinal¹H MRS assessment of the thalamus in a Coriaria lactone‐induced rhesus monkey status epilepticus model