Zur Gewebekonzentration und Wirksamkeit von Ofloxacin bei chirurgischen Patienten

Abstract

Following a 400 mg preoperative oral dose, ofloxacin concentrations were measured preoperatively in serum and at the time of tissue removal in serum, gall bladder fluid, the gall bladder wall, liver tissue, muscle, fascia, subcutaneous fat and skin. Serum values were more or less constantly above 3 mg/l at all times. The highest intraoperative ofloxacin concentration was 11.85 mg/l in the gall bladder fluid. In the gall bladder wall, liver and muscle, concentrations were slightly higher than in the serum, whereas concentrations in the fascia, subcutaneous fat and skin were clearly lower than serum concentrations. Good activity was observed with regard to the MIC90 of the pathogens most commonly encountered in surgical wards.

Mycobacteria and the new quinolones

“…Therapeutic levels were also found in blister fluid (31,61), infected bone (18, 61), soft tissue (32), skin (11,32), muscle (11,18,61), liver (11), gynecological tissues (23,60), prostate (6,61), and pleural fluid (61). IN …”

Biliary Excretion of Antimicrobial Drugs

“…In patients with T tube biliary drainage, the ofloxacin concentration in T tube bile, 2 h after a single 200-mg dose, was 7.28 B 3.45 Ìg/ml. Duben et al [135] reported an ofloxacin concentration of 3.31 B 2.05 Ìg/ml in serum, 11.85 B 4.75 Ìg/ml in gallbladder bile, 4.59 B 2.72 Ìg/ml in gallbladder wall and 4.59 B 3.46 Ìg/ml in liver during cholecystectomy scheduled 9-10 h after a 400-mg single dose.…”