Zur hyperglyk�mischen Wirkung von Serotonin und Augenstielextrakt beim Flu�krebs Orconectes limosus

Keller, Rainer; Beyer, Jens

doi:10.1007/bf00298812

Cited by 67 publications

(15 citation statements)

References 9 publications

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“…and further inputs from areas next to the olfactory-globular tract (OGT), the likely PDH-ir (see below) optic-globular tract (OPT-GT) which is connected to the so-called diamedullary neuropil adjacent to the medulla and lobula (terminology according to (123), apart from other inputs originating in the brain (77). As judged from pharmacological experiments, serotonin (103,180,181), GABA (182), dopamine (183), and several other components (see 178) likely regulate CHH rhythmicity. Furthermore, axonal terminals of brain extraretinal photoreceptors contacting serotonin-ir fibres within the protocerebral bridge of the brain (184,185) may convey circadian information via electron-microscopically proven serotonergic inputs to the XOSG (186).…”

Section: Crustacean Hyperglycaemic Hormone (Chh)mentioning

confidence: 99%

“…This finding is particularly puzzling since the established effect of 5-HT-induced CHH release in the eyestalk leading to increased haemolymph glucose levels (103,180,181) requires the activation of pharmacologically characterised 5-HTR 1 -and 5-HTR 2 -like receptors that can be blocked by the 5-HT-antagonist methysergide (254,255). It is still not clear whether this effect is brought about by 5-HT from neuronal sources in the brain or in the eyestalk, since the eyestalk contains a large number of 5-HT-ir neurons, which can release 5-HT in a paracrine manner depending upon activity (256).…”

Section: Serotoninmentioning

confidence: 99%

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Circadian clocks in crustaceans: identified neuronal and cellular systems

Strauß

Dircksen²

2010

Front Biosci

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Circadian rhythms are known for locomotory and reproductive behaviours, and the functioning of sensory organs, nervous structures, metabolism and developmental processes. The mechanisms and cellular bases of control are mainly inferred from circadian phenomenologies, ablation experiments and pharmacological approaches. Cellular systems for regulation summarised here comprise the retina, the eyestalk neuroendocrine X-organ-sinus gland system, several neuropeptides such as red pigment concentrating, hyperglycaemic and pigment-dispersing hormones, and factors such as serotonin and melatonin. No master clock has been identified, but a model of distributed clockwork involves oscillators such as the retinular cells, neurosecretory systems in the optic lobes, putative brain pacemakers, and the caudal photoreceptor. Extraretinal brain photoreceptors mediate entrainment. Comparative analyses of clock neurons and proteins known from insects may allow the identification of candidate clock neurons in crustaceans as putative homologues in the two taxa. Evidence for the existence of "insect-like" intracellular clock proteins and (light sensitive) transcription factors is scarce, but clock-, period-, and cryptochrome-gene products have been localised in the CNS and other organs rendering further investigations into crustacean clockwork very promising.

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Section: Crustacean Hyperglycaemic Hormone (Chh)mentioning

confidence: 99%

Section: Serotoninmentioning

confidence: 99%

Circadian clocks in crustaceans: identified neuronal and cellular systems

Strauß

Dircksen²

2010

Front Biosci

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“…That serotonin is involved in the regulation of hemolymph glucose concentration, possibly controlling the release of neurohormones from the X-organ/sinus gland complex, has been demonstrated several times (15)(16)(17)(18). Nevertheless, the exact nature of this effect is not well established.…”

Section: Controlmentioning

confidence: 99%

Effects of serotonin and fluoxetine on blood glucose regulation in two decapod species

Santos

Keller

Rodríguez

et al. 2001

Braz J Med Biol Res

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One of the best known crustacean hormones is the crustacean hyperglycemic hormone (CHH). However, the mechanisms involved in hormone release in these animals are poorly understood, and thus constitute the central objective of the present study. Different groups of crustaceans belonging to diverse taxa (Chasmagnathus granulata, a grapsid crab and Orconectes limosus, an astacid) were injected with serotonin, fluoxetine, or a mixture of both, and glycemic values (C. granulata and O. limosus) and CHH levels (O. limosus) were determined after 2 h in either submerged animals or animals exposed to atmospheric air. Both serotonin and fluoxetine caused significant hyperglycemia (P<0.05) after injection into the blood sinus of the two species, an effect enhanced after exposure to atmospheric air. In C. granulata blood glucose increased from 6.1 to 43.3 and 11.4 mg/100 ml in submerged animals and from 5.7 to 55.2 and 22.5 mg/100 ml in air-exposed animals after treatment with serotonin and fluoxetine, respectively. In O. limosus the increases were from 1.2 to 59.7 and 135.2 mg/100 ml in submerged animals and from 2.5 to 200.3 and 193.6 mg/100 ml in air-exposed animals after treatment with serotonin and fluoxetine, respectively. Serotonin and fluoxetine also caused a significant increase in the circulating levels of CHH in O. limosus, from 11.9 to 43 and 45.7 fmol/ml in submerged animals and from 13.2 to 32.6 and 45.7 fmol/ml in air-exposed animals, respectively, thus confirming their action as neuroregulators in these invertebrates.

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“…Entretanto, a literatura tem registrado o estímulo da serotonina na liberação de diversos hormônios, tais como o hormônio hiperglicemiante (Keller & Bayer, 1968), o hormônio dispersante do pigmento vermelho (Rao & Fingerman, 1970), o hormônio neurodepressor (Arechiga et al, 1985) e o hormônio inibidor da muda (Mattson & Spaziani, 1985). Investigando o papel da serotonina na indução da maturação ovariana em Uca pugilator, Richardson et al (1991) aventam o papel indireto da serotonina para estimular a liberação do hormônio estimulador da gônada, o que foi confirmado posteriormente pelas investigações de para Procambarus clarkii in vivo e por Sarojini et al (1995b) in vitro nesta mesma espécie.…”

Section: Diâmetro Médio Dos Ovócitos (µM)unclassified

“…Estudos mais recentes têm investigado o papel de neurotransmissores na liberação de neurohormônios em crustáceos (Keller & Bayer, 1968;Rao & Fingerman, 1970;Arechiga et al, 1985;Mattson & Spaziani, 1985;Fingerman & Rosenberg, 1988;Richardson et al, 1991;Kulkarni & Fingerman, 1992), sendo registrado o papel da serotonina neste processo (Richardson et al, 1991;Kulkarini & Fingerman, 1992;Sarojini et al, 1995b).…”

Section: Introductionunclassified

Avaliação do efeito da serotonina (5-HT) e da monoablação do pedúnculo ocular na indução da maturação ovariana de Penaeus penicillatus (Alcock, 1905)

Oliveira

Correa²

1999

Rev. Bras. Biol.

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Evaluation of the effect of serotonin (5-HT) and eyestalk monoablation on the induction of ovary maturation in Penaeus Penicillatus (Alcock, 1905)The effects of serotonin and of the monoablation of eyestalk on the induction of gonadal development of Penaeus penicillatus (red tail shrimp) were investigated. Immature females with an average weight of 20 g were selected and ramdonly distributed into four groups of 5 animals as follows: initial control group (IC), sacrificed at the 1 st day of the experiment; parallel control group (CG), injected with 0.05 ml of saline solution; monoablated group (AG), submitted to monoablation at day 0 and injected with 0.05ml of saline immediatelly after the monoablation and on the 5 th day; serotonin group (SG), injected with 0.05 ml of serotonin, dissolved in saline solution, both on day 0 on the 5 th day, in a total dose of 15 µg per gram of animal's weight (7,74 x 10 -7 mol). Animals were sacrificed on day 0 for the initial control group (IC), and on the 5 th , 10 th and 15 th days for the other groups. A fragment from the front lobe of the animal's gonad was fixed in aqueous Bouin and processed with the usual optic microscopy techniques. Analyses consisted of a morphological description of cells and measurements of the diameter of oocytes, which gave evidence to the stimulating role of serotonin and of monoablation on gonad maturation. The statistical analysis (Anova -SNK, P < 0.05) of the diameter values of oocytes showed monoablation to be more effective in inducing ovary maturation than serotonin at the concentration used (7,74 x 10 -7 mol).Key words: Penaeus sp., serotonin, 5-HT, reproduction, ovary maturation. RESUMOO efeito da serotonina e da monoablação do pedúnculo ocular na indução do desenvolvimento gonadal de Penaeus penicillatus (camarão do rabo vermelho) foi investigado. Fêmeas imaturas com peso médio de 20 g foram selecionadas e distribuídas de maneira aleatória em quatro grupos de 5 animais com uma réplica para cada grupo: grupo controle inicial (CI), sacrificado no 1 o dia do experimento; grupo controle paralelo (GC), injetado com 0,05 ml de solução salina; grupo monoablado (GA), submetido à monoablação no dia 0 e injetado com 0,05 ml de solução salina logo após a monoablação e no 5 o dia; grupo serotonina (GS), injetado com 0,05 ml de serotonina dissolvida em solução salina no dia 0 e 5 o dia, numa dose total de 15 µg por grama de peso do animal (7,74 x 10 -7 mol). Os animais do grupo controle inicial (CI) foram sacrificados no dia 0, e no 5 o , 10 o e 15 o dias para os demais grupos, respectivamente. Fragmentos dos lóbulos anteriores das gônadas dos animais foram fixados em Bouin

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Zur hyperglyk�mischen Wirkung von Serotonin und Augenstielextrakt beim Flu�krebs Orconectes limosus

Cited by 67 publications

References 9 publications

Circadian clocks in crustaceans: identified neuronal and cellular systems

Circadian clocks in crustaceans: identified neuronal and cellular systems

Effects of serotonin and fluoxetine on blood glucose regulation in two decapod species

Avaliação do efeito da serotonina (5-HT) e da monoablação do pedúnculo ocular na indução da maturação ovariana de Penaeus penicillatus (Alcock, 1905)

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