Zur klinischen Relevanz nootroper Effekte

Zimmer, R.; Kurz, A.; Lauter, H.

doi:10.1007/978-3-642-71539-6_5

Cited by 5 publications

(1 citation statement)

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“…Thus, the class of nootropics, covers agents of various chemical structures and diverse mechanisms of action which have a common therapeutic profile. Examples include the classical nootropics [piracetam, pyritinol, meclofenoxate (centrophenoxine)], drugs with nootropic components of activity, such as, synthetic ergot derivatives, tacrine and other cholinomimetics, neuropeptides such as the hypophyseal peptide fragment alaptide, and calcium antagonists such as nimodipine (Benesova et al 1991 b;Coper & Herrmann 1988;Coper & Kanowski 1983;Helmchen 1988;Kanowski et al 1989;Moller 1993;Muller 1988a,b;Muller 1990;Sarter 1986;Zimmer et al 1987).…”

Section: Definition Of Nootropic Drugsmentioning

confidence: 98%

Neuropathobiology of Senile Dementia and Mechanism of Action of Nootropic Drugs

Benešová

1994

Drugs & Aging

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Recent advances in neuroscience and molecular neurochemistry have substantially increased the knowledge of the neuropathobiology of senile dementia and Alzheimer's disease. On the basis of various hypotheses concerning degenerative processes in aging brains, new therapeutic strategies have been developed, including nootropic drugs with different mechanisms of action and heterogenous chemical structures. Mutual relationships exist between neuroscientific research and nootropic drug development. To date, such areas of research and drug development have involved deficits of brain neurotransmission (cholinergic, monoaminergic, peptidergic), free radical-induced damage, disturbances of calcium homeostasis and excitatory amino acid function, and deposition of amyloid protein.

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