Zur Morphologie der Plazenta bei Raucherinnen

Lohr, Jens G.; Dehnhard, F; Wehler, V.; Ardelt, Wojciech

doi:10.1007/bf00669136

Cited by 4 publications

(1 citation statement)

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“…Other findings have often proved inconsistent, or even contradictory. For example Lohr et al (1975) reported an increased frequency of obliterative endarteritis within the villi, but this was not confirmed by Spira et nl. (1977), Naeye (1978) or Van der Veen & Fox (1982).…”

Section: )mentioning

confidence: 86%

Morphometric differences between the placental vasculature of non‐smokers, smokers and ex‐smokers

Burton¹,

Palmer²,

Dalton³

1989

BJOG

100

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The aim of this study was to determine whether cigarette smoking during pregnancy has an adverse effect upon the placenta's capacity for gaseous exchange. Using recently developed stereological techniques, in conjunction with perfusion fixation, computer-assisted measurements were made on the placentas of 15 non-smokers, 15 moderate smokers, 15 heavy smokers and 13 ex-smokers, 7 of whom stopped smoking during the course of the pregnancy. Compared with the placentas of non-smokers and of those who stopped before pregnancy, it was found that the placentas of smokers and of those who stopped after conception exhibited a reduced capillary volume fraction, and an increased thickness of the villous membrane. Although they must impair gaseous exchange across the placenta, these changes were less severe than suggested by previously published reports. Nonetheless it is clear that in order to prevent these changes women should stop smoking before conception rather than during the course of a pregnancy.Maternal cigarette smoking during pregnancy has been known for many years to be associated with a significant reduction in birthweight (see Pirani 1978 for historical review), yet the cause for this growth retardation is still not clear. As in any other pregnancy the normal functioning of the placenta is essential for fetal well-being and so it is surprising that few quantitative studies have been performed to investigate the effects of cigarette smoking on placental structure.On gross examination placentas from smokers appear normal (Mulcahy et al. 1970;

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confidence: 86%