Zur physikalisch-chemischen Charakterisierung von 5-Amino-1-aryl-1H-tetrazolen: Charakterisierung von Wasserlöslichkeiten und ihre Beziehungen zu Octan-1-ol/Wasser-Verteilungskoeffizienten

Abstract

Abstract. The aqueous solubilities (logS) of a set of 27 5-amino-1-aryl-1H-tetrazoles with known biological activity were determined photometrically and correlated with their octan-1-ol/water partition coefficients (logP). The otained linear relationship between logS and logP can be significantly improved by a melting point term, an electronic term and several indicator variables describing the deviating solubility behaviour of compounds with hydrogen bonding groups and the dependence on substituent position. The calculated moreparameter equations allow the reliable prediction of aqueous solubilities for 5-amino-1-aryl-1H-tetrazoles not yet synthesized or investigated.Abb. 1 Zusammenhang zwischen den experimentell bestimmten Logarithmen der Wasserlöslichkeiten logS und Octan-1-ol/Wasser-Verteilungskoeffizienten logP substituierter 5-Amino-1-aryl-1H-tetrazole; eingezeichnet ist die Regressionsgerade zu Gl. (3) für nicht wasserstoffbrückenbindende Substituenten in meta-und para-Position ( ), dabei nicht berücksichtigt wurden sauerstoffhaltige Substituenten in diesen Positionen ( ) sowie die entsprechenden Substituenten in ortho-Position ( , ∆) 1 ) QSAR = quantitative structure-activity relationship(s), QSPR = quantitative structure-property relationship(s).

Synthesis of 1-Substituted 1H-1,2,3,4-Tetrazoles Using Biosynthesized Ag/Sodium Borosilicate Nanocomposite

“…Tetrazoles are a significant class of heterocyclic compounds with wide-ranging applications in diverse areas of industry and science . Recently, they have attracted considerable attention because of their extensive utility in coordination chemistry, − medicinal chemistry and pharmaceutical sciences, − and also in materials science including oxygen-containing fuels. − Tetrazoles can be utilized as precursors for diverse nitrogen-containing compounds (e.g., triazoles, thiazoles, and oxazolidones). , Due to their broad applications, the investigation on the catalytic preparation of tetrazoles has been of immense interest, and especially, 1-substituted tetrazole derivatives have been the subject of fundamental research in view of their biological and medical applications …”

Application of a functionalized mesoporous silica catalyst to the synthesis of tetrazoles

“…Tetrazoles are screened for various biological activities such as antiulcer [4], anticonvulsant [5], antiviral, antibacterial, antifungal, anti-inflammatory [6], antiallergic [7], and antitubercular activities [8]. In addition, tetrazoles have been applied in numerous material sciences and synthetic organic chemistry as analytical reagents [10,11]. In addition, tetrazoles have been applied in numerous material sciences and synthetic organic chemistry as analytical reagents [10,11].…”