Zur Resorption von Sorbit und Mannit

Ruttloff, H.; Ketz, H.-A.; Witt, Heiko; Tietz, I.; Emmer, Ingrid

doi:10.1002/food.19610050603

Cited by 14 publications

(6 citation statements)

References 36 publications

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“…The lack of SDH mRNA in this tissue could be in accordance with findings showing that sorbitol resorption in rat occurs by means of passive diffusion in jejunum and ileum (Lauwers et al, 1985), yielding sorbitol in the portal vein shortly after injection into the small intestine (Ruttloff and Ketz, 1961). At the same time, plasma sorbitol concentrations were very low (Ruttloff and Ketz, 1961), indicating substantial hepatic uptake and metabolism of sorbitol, in agreement with the large amounts of SDH mRNA in the liver (Table 1).…”

Section: Tissuesupporting

confidence: 74%

Distribution of alcohol and sorbitol dehydrogenases

Estonius

Danielsson

Karlsson

et al. 1993

European Journal of Biochemistry

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The tissue distribution of mRNA of alcohol dehydrogenases of classes I, II and III, and sorbitol dehydrogenase, was studied. mRNA from 19 different rat tissues was purified and analyzed by Northern blots, utilizing cDNA probes specific for the four dehydrogenases. Class‐I alcohol‐dehydrogenase mRNA was shown to be of widespread occurrence, detectable in all tissues including brain, but with pronounced differences in amounts. Hybridization revealed the pattern of occurrence of class‐II alcohol‐dehydrogenase mRNA to be unique, with transcripts only in the liver, duodenum, kidney, stomach, spleen and testis. Abundant levels of class‐III alcohol‐dehydrogenase (glutathione‐dependent formaldehyde dehydrogenase) mRNA were present in all tissues analyzed, reflecting the general need for scavenging of formaldehyde in physiological cytoprotection. Sorbitol dehydrogenase mRNA was detected in all tissues except small intestine, in agreement with sorbitol resorbtion by passive diffusion in this tissue. In addition, evidence for a sex‐specific expression, in the liver, of class‐II alcohol dehydrogenase was obtained.

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Section: Tissuesupporting

confidence: 74%

Distribution of alcohol and sorbitol dehydrogenases

Estonius

Danielsson

Karlsson

et al. 1993

European Journal of Biochemistry

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“…It should be kept in mind that a comparison of GPS and GPM did not produce any real difference in energy-limited growth of rats, which proves equal utilisation of bound sorbitol and mannitol respectively. This finding is at variance with the reported, almost complete non-utilisation of free mannitol [15,17,20,27,29,41,44,49,54]; it remains to be seen whether the established slow release of mannitol from GPM (Table 1), leading to a constant, though small availability of this hexitol during intestinal passage (Table 2), could suffice to explain the different behaviour of free and glycoside-bound mannitol. Some differences between sorbitol and GPS seem to fall into the same category since free sorbitol, in contrast to GPS, does not exhibit reduced caloric utilisation in maintenance experiments 3.…”

Section: Discussioncontrasting

confidence: 70%

Metabolism of hydrogenated palatinose, an equimolar mixture ofα-D-glucopyranosido-1,6-sorbitol andα-D-glucopyranosido-1,6-mannitol

Grupp

Siebert

1978

Res. Exp. Med.

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Hydrogenated palatinose, an equimolar mixture of alpha-D-glucopyranosido-1,6-sorbitol and alpha-D-glucopyranosido-1,6-mannitol, was investigated as a potential oral sugar substitute in the following experiments in man and rat. 1. Enzymatic cleavage occurred at slow rates by maltase (alpha-glucosidase) of jejunal mucosa, liver lysosomes and yeast. 2. Part of ingested hydrogenated palatinose arrived unsplit at the caecum of the rat and underwent fermentation there; excretion in feces and urine are neglegible in man and rat. 3. Growth and maintenance of rats demonstrated 20--40 percent diminished caloric utilisation of diets containing 34.5 percent hydrogenated palatinose whereas indirect calorimetry in man showed about 50 percent caloric deficit. 4. Blood sugar did not increase in man after oral doses up to 100 g. 5. The capacity of the rat kidneys for excretion of hydrogenated palatinose and its constituents was high, symptoms of incompatibility were not observed.

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“…Mitchell et al (1937) observed a slight impairment in the digestibility of organic nutrients in a sucrose ration for rats, as compared with a ration containing glucose, and a slower rate of growth and of protein deposition on a fructose-containing ration. In the same species, Ruttloff and Ketz (1961) observed a decreased absorption rate for fructose as compared with glucose.…”

mentioning

confidence: 77%