Zur Ultrastruktur der Onkocytome

Hübner, G; Klein, H. J.; Schümmelfeder, Norbert

doi:10.1007/bf01720473

Cited by 23 publications

(7 citation statements)

References 6 publications

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“…Our studies con® rm the original reports of the structure of oncocyte mitochondria based on TEM [1,2]. Commonly, these enlarged organelles contain a stack of lamelliform cristae, each of which is in direct continuity with the inner limiting (boundary) mitochondrial £ 35,000).…”

Section: Discussionsupporting

confidence: 88%

“…From their initial detailed ultrastructural description in Warthin's tumor [1] and in oncocytomas [2], it has been apparent that all oncocytes, irrespective of their site of occurrence, have the same basic ultrastructural organization. They all contain a plethora of mitochondria which are responsible for the granular and eosinophilic appearance of these cells examined in the light microscope [3].…”

mentioning

confidence: 99%

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Three-Dimensional Structure of Oncocyte Mitochondria in Human Salivary Glands: A Scanning Electron Microscope Study

Riva

Tandler

2000

Ultrastructural Pathology

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Oncocytes occurring in otherwise normal human salivary glands were examined by scanning electron microscopy after being subjected to a maceration technique that removes all soluble cytoplasmic components and leaves only membranes in place. The three-dimensional images resulting from this procedure confirm that the majority of oncocyte mitochondria have shelf-like cristae that are attached to the inner boundary membrane, often by means of tubular structures. In some mitochondria, the cristae are digitiform and, when transected, give rise to putative vesicles. The oncocytic mitochondria in human salivary glands, by and large, lack the structural irregularity that has been reported for these organelles occurring in oncocytes in other organs.

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Section: Discussionsupporting

confidence: 88%

mentioning

confidence: 99%

Three-Dimensional Structure of Oncocyte Mitochondria in Human Salivary Glands: A Scanning Electron Microscope Study

Riva

Tandler

2000

Ultrastructural Pathology

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“…This conclusion ®ts with the results that we have obtained in a study of tumours and tumour-like lesions of the thyroid, including two Hu È rthle (oxyphil) cell lesions [2].…”

supporting

confidence: 88%

“…6]), the level of the 4977 bp deletion ranged from 0.7 to 16.1% (Table 1). We have also detected the mtDNA deletion in the thyroid parenchyma adjacent to Hu È rthle cell tumours and other types of thyroid tumours, particularly when the`normal' thyrocytes displayed a slightly abundant and granular cytoplasm [2]. In these settings, the Letter to the Editor Authors' reply.…”

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confidence: 77%

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Mitochondrial DNA ?common? deletion in H�rthle cell lesions of the thyroid

Máximo

Sobrinho‐Simöes

2000

J. Pathol.

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Detection of damage to the mitochondrial genome in the oncocytic cells of Warthin's tumour

et al. 2000

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Warthin's tumour of the salivary glands is composed of oncocytic cells containing excessive numbers of mitochondria which show frequent structural abnormalities and reduced metabolic function. Recent evidence of a strong association between cigarette smoking and the occurrence of Warthin's tumour prompted this study, to look for evidence of damage to mitochondrial DNA (mtDNA) that could be the result of an increase in oxidative stress; two-colour¯uorescence in situ hybridization (FISH) was developed to show the distribution of mitochondria with deleted mtDNA in paraf®n wax-embedded material. Approximately 10% of mtDNA bears the`common' 4977 bp deletion. Using the polymerase chain reaction (PCR), the 4977 bp deletion was further quanti®ed, in Warthin's tumour and age-matched normal parotid control tissue. Whilst the deletion was present in all parotid tissue, its presence was signi®cantly higher in oncocytic tumour cells. In a small number of controls, there was a trend towards higher concentrations of the deletion in smokers.

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Zur Ultrastruktur der Onkocytome

Cited by 23 publications

References 6 publications

Three-Dimensional Structure of Oncocyte Mitochondria in Human Salivary Glands: A Scanning Electron Microscope Study

Three-Dimensional Structure of Oncocyte Mitochondria in Human Salivary Glands: A Scanning Electron Microscope Study

Mitochondrial DNA ?common? deletion in H�rthle cell lesions of the thyroid

Detection of damage to the mitochondrial genome in the oncocytic cells of Warthin's tumour

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