Zwitterionic/phosphonate copolymer coatings endow excellent antifouling properties and robust re-mineralization ability of dentine substrates

Dong, Xinhua; Wan, Pingyu; Sun, Jin; Li, Youxin; Fan, Birong; Dong, Yaning; Gan, Donglin; Zhang, Weibing; Liu, Pingsheng; Shen, Jian

doi:10.1039/d2tb00750a

Cited by 7 publications

(1 citation statement)

References 46 publications

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“…In addition to their marked antifouling properties, zwitterionic polymers have recently been reported as a type of high efficiency biomineralization ligand for calcium phosphate. 110 In fact, the oppositely charged moieties of a zwitterion resemble the positively and negatively charged residues of an extracellular matrix where biomineralization of bone tissue takes place. Shen et al designed and synthesized a zwitterionic/phosphonate copolymer p(DEMMP- co -MPC) (Fig.…”

Section: Antifouling Polymers As Coatingsmentioning

confidence: 99%

Antifouling polymers for nanomedicine and surfaces: recent advances

Eng,

Nguyen,

Luo

et al. 2023

Nanoscale

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Section: Antifouling Polymers As Coatingsmentioning

confidence: 99%

Antifouling polymers for nanomedicine and surfaces: recent advances

Eng,

Nguyen,

Luo

et al. 2023

Nanoscale

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An Adhesive/Anti‐Adhesive Janus Tissue Patch for Efficient Closure of Bleeding Tissue with Inhibited Postoperative Adhesion

et al. 2023

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Most of the current bioadhesives cannot perform well on bleeding tissues while postoperative adhesion is a general but serious clinical issue. Here, a three‐layer biodegradable Janus tissue patch (J‐TP) that is able to simultaneously enable efficient closure of bleeding wounds with significantly promoted clotting ability and suppressed postoperative adhesion of tissues is reported. A dry adhesive hydrogel bottom layer of the J‐TP can form rapid (within 15 s) and strong (tensile strength up to 98 kPa) adhesion to bleeding/wet tissues with high bursting pressure (about 312.5 mmHg on a sealed porcine skin) through hydrogen binding and covalent conjugation between the carboxyl & N‐hydroxy succinimide (NHS) groups of hydrogel and the primary amine groups of tissues, while the phosphonic motifs can significantly reduce blood loss (by 81% on a rat bleeding liver model) of bleeding wounds. A thin polylactic acid (PLA) middle layer can improve the tensile strength (by 132%) of the J‐TP in wet conditions while the grafted zwitterionic polymers can effectively prevent postoperative tissue adhesion and inflammatory reaction. This J‐TP may be a promising tissue patch to assist the clinical treatment of injured bleeding tissues with inhibited postoperative adhesion.

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Recent advances of multifunctional zwitterionic polymers for biomedical application

Lv,

Wang,

et al. 2024

Acta Biomaterialia

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Zwitterionic/phosphonate copolymer coatings endow excellent antifouling properties and robust re-mineralization ability of dentine substrates

Abstract: Inhibition of the biofilm formation and induction of the re-mineralization of damaged dental tissues are two major strategies to combat the dental hypersensitivity (DH). However, single component synthetic materials normally...

Cited by 7 publications

References 46 publications

Antifouling polymers for nanomedicine and surfaces: recent advances

Antifouling polymers for nanomedicine and surfaces: recent advances

An Adhesive/Anti‐Adhesive Janus Tissue Patch for Efficient Closure of Bleeding Tissue with Inhibited Postoperative Adhesion

Recent advances of multifunctional zwitterionic polymers for biomedical application

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