Zygote transfer on day 1 versus cleavage stage embryo transfer on day 3: a prospective randomized trial

Jaroudi, Kamal; Al-Hassan, Saad; Sieck, Ulla V.; Al-Sufyan, Hamad; Al-Kabra, Maya; Coşkun, Serdar

doi:10.1093/humrep/deh125

Cited by 31 publications

(19 citation statements)

References 25 publications

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“…Pregnancy rates were higher in the day 3 group (42%) compared with the day 1 group (28%) (Joroudi et al 2004). Although an increase in clinical pregnancy rate with day 3 embryo transfer was demonstrated, at present there is no sufficient evidence to suggest an improvement in live births when the embryo transfer is delayed from day 2 to day 3 (Oatway et al 2004).…”

Section: Embryo Transfermentioning

confidence: 81%

Intracytoplasmic sperm injection: An assisted reproductive technique and its outcome to overcome infertility

Sarkar

2007

Journal of Obstetrics and Gynaecology

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This review focuses on the outcome, merits and demerits of intracytoplasmic sperm injection (ICSI) for treatment of male factor infertility. Spermatozoa of infertile men are surgically retrieved from the epididymis or testis. Fertilisation and pregnancy rates after ICSI are found to be around 66% and 48%, respectively, with surgically retrieved spermatozoa. Major contributing factors to failed fertilisation after ICSI are the number of metaphase II oocytes retrieved and availability of viable spermatozoa for injection. Children born after ICSI have an increased risk of major congenital deformity as compared with children born naturally. Both paternal and maternal risk factors seem to pose an increased risk of congenital malformations in the offspring born after ICSI. The ICSI technique per se is not an independent risk factor. Qualitative differences in development and social interaction between ICSI and natural children appears to be related to developmental processes of the entire family unit. Parents of ICSI children have a good relationship with their children.

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Section: Embryo Transfermentioning

confidence: 81%

Intracytoplasmic sperm injection: An assisted reproductive technique and its outcome to overcome infertility

Sarkar

2007

Journal of Obstetrics and Gynaecology

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“…In 38 [10-12,14-24,26-49] out of 40 (95.0%) studies included in the final analysis, zygote morphology was a part of cumulative morphological score during embryo development, whereas in the other 2 studies [13,25] (5.0%) zygote morphology was the only parameter for embryo transfer.…”

Section: Resultsmentioning

confidence: 99%

“…Of these, 15 (60.0%) found a correlation [10,11,13,14,19,21,23,26],[27,29,33,34,37,39,40], while 10 studies (40.0%) did not find any correlation [12,17,25,28,30,38,39,41],[43,46]. …”

Section: Resultsmentioning

confidence: 99%

Pronuclear morphology evaluation for fresh in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles: a systematic review

et al. 2013

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The current systematic review was aimed to assess the effectiveness of the zygote morphology evaluation in fresh in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles. All available studies reporting on zygote morphology and clinical and/or biological outcomes were analyzed. Forty studies were included in the final analysis. Fourteen different zygote scoring systems were employed. Zygote morphology correlated significantly with embryo quality and cleavage, blastocyst stage, embryonic chromosome status, in a high proportion of the studies which assessed the specific outcome [15/25 (60%), 15/20 (75%), 7/8 (87.5%), 6/6 (100%), respectively]. On the other hand, only a reduced proportion of papers showed a statistically significant relationship between implantation, pregnancy and delivery/live-birth rates and zygote morphology score [12/23 (52.2%), 12/25 (48%), 1/4 (25%), respectively]. In conclusion, our findings demonstrate the lack of conclusive data on the clinical efficacy of the zygote morphology evaluation in fresh IVF/ICSI cycles, even if biological results showing a good relationship with embryo viability suggest a role in cycles in which the transfer/freezing is performed at day 1.

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“…Par ailleurs, le lien entre les différents profils de zygotes à j1 et la qualité embryonnaire à j2/j3 diffère également selon les études. Plusieurs études n'ont pas observé de différence significative en termes de morphologie embryonnaire entre les profils 0 et non 0 [18,19]. En revanche, dans notre suivi individuel, le profil 0 est associé à une fréquence plus élevée d'embryons de bonne qualité en accord avec d'autres études [5,17,20].…”

Section: Discussionunclassified

Suivi individuel des embryons en FIV

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Poindron

Bidault

et al. 2006

Gynécologie Obstétrique & Fertilité

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Zygote transfer on day 1 versus cleavage stage embryo transfer on day 3: a prospective randomized trial

Abstract: Day 3 embryo transfers result in better pregnancy and implantation rates compared to day 1 zygote transfers. The present pronuclei scoring cannot reliably select zygotes for transfer on day 1.

Cited by 31 publications

References 25 publications

Intracytoplasmic sperm injection: An assisted reproductive technique and its outcome to overcome infertility

Intracytoplasmic sperm injection: An assisted reproductive technique and its outcome to overcome infertility

Pronuclear morphology evaluation for fresh in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles: a systematic review

Suivi individuel des embryons en FIV

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