α-Adrenoceptor-Mediated Coronary Artery Spasm

Levene, Donald L.

doi:10.1001/jama.1976.03270100018019

Cited by 57 publications

(2 citation statements)

References 8 publications

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“…The effects of alpha 1 -adrenergic receptors on abnormal coronary vasoconstriction are not yet elucidated as there is limited and conflicting evidence [70] , [71] , [72] , [73] , [74] , [75] .…”

Section: Symptom Reducingmentioning

confidence: 99%

Pharmacotherapy in patients with vasomotor disorders

Boerhout,

Feenstra,

van de Hoef

et al. 2023

IJC Heart & Vasculature

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Section: Symptom Reducingmentioning

confidence: 99%

Pharmacotherapy in patients with vasomotor disorders

Boerhout,

Feenstra,

van de Hoef

et al. 2023

IJC Heart & Vasculature

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“…Coronary vasospasm can be prevented in patients with variant angina by the administration of the a-adrenoceptor blocking agents phenoxybenzamine (35,36) and phentolamine (37). Levine and Freeman describe a patient in which exercise tolerance and the post-exercise electrocardiogram were both substantially improved by oral treatment with phenoxybenzamine (37).…”

Section: Physiological and Possible Clinical Significance Of Coronarymentioning

confidence: 99%

The evidence for α-adrenoceptors in the coronary circulation and their possible relevance to the physiological regulation of myocardial blood flow

Parratt

1981

Basic Res Cardiol

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This contribution reviews the evidence for the existence of a-adrenoceptors mediating vasoconstriction in the coronary vascular bed and discusses their possible physiological, pharmacological and clinical relevance. It attempts to serve as an introduction to the papers in this symposium which deal with the role of the sympathetic nerves in the control of coronary vessel tone. Evidence for the presence of coronary vascular a-adrenoceptors mediating vasoconstrictionThe experimental evidence for the presence of coronary vascular a-adrenoceptors comes both from in-vitro and in-yivo studies: I. a-adrenoceptors in the coronary circulation: evidence from isolated coronary vesselsOne of the problems involved in analysing adrenoceptor types in the coronary circulation' is that most of the commonly used agonists (e.g. adrenaline, noradrenaline) influence both coronary and myocardial a-and [~-adrenoceptors. A drug may have a direct constrictor effect on the coronary vessels (mediated, for example, through coronary vascular smooth muscle a-adrenoceptors) yet increase coronary flow through stimulation of myocardial work and metabolism (mediated, for example, through myocardial [3-adrenoceptors). This separation of direct (vascular) from indirect (myocardial) effects is especially difficult with regard to drugs which influence adrenoceptors. One obvious way of separating metabolically mediated from direct coronary vascular effects is to examine the responses of isolated coronary vessels. It must however, be emphasised that such studies do not yield definitive information about the responses of such vessels in vivo nor about the responses of the coronary arterioles, the main resistance segment of the coronary vascular bed. The classic studies in this field are those of Bohr (1, 2) who examined the responses of canine coronary arteries of different sizes ('small', 250-500 ~ and 'large' 1.5-2.4 mm diameter) to adrenoceptor agonists. A more detailed study of the responses of pig coronary arteries (spiral strips from arteries 1.5-2.4 mm diameter) has been undertaken by Abaitey (3). The predomin-978

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Coronary artery spasm: Its role in the pathogenesis of myocardial ischemia

Chahine

1979

Clinical Cardiology

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The role of coronary artery spasm in the production of myocardial ischemia has recently become the focus of increased attention. This phenomenon is now well established as a causative mechanism underlying the resting chest pain attacks in Prinzmetal's variant angina. There is also evidence that coronary spasm may play a more significant role in the broad spectrum of ischemic heart disease than can be documented by current techniques. The autonomous nervous system constitutes a major element in the pathophysiology of spasm. Coronary arteriography, in spite of important limitations, remains the only technique for final documentation of this phenomenon, but radionuclide scintigraphy appears to be promising. Nitroglycerin is effective for the relief of the acute attack, while long acting nitrates and the calcium antagonists: nifedipine, perhexiline and verapamil are useful in the prevention of recurrences.

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α-Adrenoceptor-Mediated Coronary Artery Spasm

Cited by 57 publications

References 8 publications

Pharmacotherapy in patients with vasomotor disorders

Pharmacotherapy in patients with vasomotor disorders

The evidence for α-adrenoceptors in the coronary circulation and their possible relevance to the physiological regulation of myocardial blood flow

Coronary artery spasm: Its role in the pathogenesis of myocardial ischemia

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