α-Adrenoceptors in Dog Mesenteric Vessels–Subcellular Distribution and Number of [3H]Prazosin and [3H]Rauwolscine Binding Sites

1 We investigated the nature of the adrenoceptors in the dog saphenous vein (DSV) and dog mesenteric vein (DMV) to determine the nature of the unexpected interactions of phenylephrine and methoxamine with rauwolscine in the DSV, i.e. the ability of the putative a2-adrenoceptor antagonist to inhibit competitively contractions to these ax-agonists. Radioligand binding studies were performed in parallel with contractility studies.

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“…The procedures have been described by Kwan et al (1983) and by Shi et al (1989a,b;1990). The procedures were as follows.…”

Section: Dissection For Membrane Preparationmentioning

confidence: 99%

Unusual αadrenoceptor subtype in canine saphenous vein: comparison to mesenteric vein

Daniel

Low

Gaspar

et al. 1996

British J Pharmacology

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“…In addition, the involvement of imidazoline-binding sites (Bousquet & Feldman, 1987;Ernsberger et al, 1987) has been proposed for some of these drugs (clonidine, rilmenidine). a^Adrenoceptors are present in the vasculature, as has been proven by ligand-binding studies (Schmitz et al, 1981;Shi et al, 1990;Elhawary et al, 1992). Stimulation of presynaptic aijadrenoceptors inhibits adrenergic (Armstrong & Boura, 1973;Medgett et al, 1978;Rump et al, 1991; and nonadrenergic neurotransmission (Mione et al, 1990;Friedman & Duckies, 1995).…”

Section: Discussionmentioning

confidence: 87%

Sympathetic nerves and alterations in vascular structure and reactivity

Eerdmans¹

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Membrane Biochemistry of Vascular Smooth Muscle of Resistance Blood Vessels and Changes in Hypertension

Kwan¹

1991

The Resistance Vasculature

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α-Adrenoceptors in Dog Mesenteric Vessels–Subcellular Distribution and Number of [3H]Prazosin and [3H]Rauwolscine Binding Sites

Cited by 16 publications

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Unusual αadrenoceptor subtype in canine saphenous vein: comparison to mesenteric vein

Unusual αadrenoceptor subtype in canine saphenous vein: comparison to mesenteric vein

Sympathetic nerves and alterations in vascular structure and reactivity

Membrane Biochemistry of Vascular Smooth Muscle of Resistance Blood Vessels and Changes in Hypertension

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