α-Atrial natriuretic peptide, aldosterone secretion and plasma renin activity during ethanol withdrawal: a correlation with the onset of delirium tremens?

Bezzegh, Attila; Nyuli, László; Kovaćs, Gábor L.

doi:10.1016/0741-8329(91)90513-v

Cited by 21 publications

(16 citation statements)

References 12 publications

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“…Some mechanisms are proposed to explain the increase in blood pressure induced by ethanol withdrawal such as activation of the systemic RAS (Bezzegh et al, 1991;Clark & Friedman, 1985;King Fig. 4.…”

Section: Discussionmentioning

confidence: 99%

“…The exact function of the vascular RAS remains elusive, but it may amplify the effects of the systemic RAS, particularly in pathological conditions, such as in hypertension (Nguyen Dinh Cat & Touyz, 2011). Ethanol withdrawal was found to activate the systemic RAS (Bezzegh et al, 1991;Clark & Friedman, 1985;King et al, 1991;Potter et al, 1983), but no information on the effects of ethanol withdrawal in the vascular RAS is available.…”

Section: Introductionmentioning

confidence: 96%

“…Previous studies have linked the pressor effects of ethanol withdrawal to increased levels of catecholamines, and activation of the hypothalamic-pituitary-adrenal axis and the renin-angiotensin system (RAS) (Bezzegh, Nyuli, & Kovács, 1991;Clark & Friedman, 1985;Potter, Bannan, Saunders, Ingram, & Beevers, 1983). The latter is critically involved in the control of blood pressure and hydromineral homeostasis.…”

Section: Introductionmentioning

confidence: 97%

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Ethanol withdrawal increases oxidative stress and reduces nitric oxide bioavailability in the vasculature of rats

Gonzaga

Mecawi²,

Antunes‐Rodrigues³

et al. 2015

Alcohol

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 97%

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Ethanol withdrawal increases oxidative stress and reduces nitric oxide bioavailability in the vasculature of rats

Gonzaga

Mecawi²,

Antunes‐Rodrigues³

et al. 2015

Alcohol

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“…This is at variance to some previous anecdotal suggestions 19,20 of participation of an activated renin-angiotensin-aldosterone system in HTN of alcoholics. Instead of consistent elevations in PRA, more accurate studies showed a trend to a fall in PRA from high-normal levels toward suppressed values in short-to medium-term withdrawing alcoholics, [21][22][23][42][43][44] a finding that may be related to the recovery from a previous dehydrated state. 23,43,44 Abnormal changes of both BP and PRA to alteration in Na intake, such as those observed in alcoholics, are typically associated with salt sensitivity in essential HTN.…”

Section: Gennaro Et Al Sodium Sensitivity and Alcoholism 871mentioning

confidence: 97%

Sodium Sensitivity of Blood Pressure in Long-Term Detoxified Alcoholics

et al. 2000

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Abstract-To investigate whether sodium sensitivity of blood pressure participates in the relationship of arterial hypertension to chronic alcohol consumption, 30 alcoholics detoxified from 6 to 12 months and 30 teetotaler controls underwent a dietary sodium manipulation study. They received a daily 55 mmol sodium diet for 7 days, followed by a 260 mmol sodium diet for 7 days. Changes in 24-hour urinary sodium excretion between the end of each period were similar in alcoholics and controls (202Ϯ16 SEM mmol and 227Ϯ11, respectively). Plasma renin activity in alcoholics was lower than in controls at both low (2.4Ϯ0.4 ng angiotensin I/mLϫh -1 versus 3.7Ϯ0.2, PϽ0.003) and high sodium intake (0.47Ϯ0.10 versus 0.82Ϯ0.10, PϽ0.05), with smaller variations in alcoholics (Ϫ1.9Ϯ0.3 versus Ϫ2.9Ϯ0.2, PϽ0.009). In alcoholics, alteration in sodium intake was followed by greater changes in both systolic and mean blood pressure (ambulatory blood pressure monitoring), which rose by 10.6Ϯ2.2 mm Hg and 7.3Ϯ1.5 versus 4.7Ϯ1.4 and 3.9Ϯ1.0 in controls, respectively (PϽ0.03 for systolic and PϽ0.05 for mean blood pressure). The ratio of changes in mean blood pressure to those in 24-hour urinary sodium excretion was higher in alcoholics (0.044Ϯ 0.011 mm Hgϫmmol Ϫ1 versus 0.018Ϯ0.0041, PϽ0.005). Our data show that in detoxified alcoholics, there is an abnormal response of both blood pressure and plasma renin activity to variations in salt intake similar to that in sodium-sensitive arterial hypertension. The precise relationship between the sodium sensitivity of blood pressure in detoxified alcoholics and the long-term influence of alcohol on blood pressure remains to be elucidated. Key Words: alcoholism Ⅲ blood pressure Ⅲ sodium sensitivity A n association between chronic exposure to alcoholic beverages and elevation in blood pressure (BP) has been widely recognized. 1Ϫ6 Cross-sectional and epidemiological reports have indicated that chronic consumption of alcohol equal to 3 drinks per day or more may be an independent variable that acts on BP (in addition to obesity, Na intake, smoking, physical activity, age, gender, and race), with a magnitude similar to that observed for obesity and even greater than that of Na intake by itself. 2,3,5 Studies in moderate drinkers and chronic alcoholics have also shown a relationship between current alcohol intake and BP, 6 -10 although no further increase in BP was detected over a daily alcohol intake of 6 drinks per day. 2,4,10 Furthermore, prospective studies have indicated that alcohol consumption was accompanied by increasing BP over time and by an elevated risk of developing clinical arterial hypertension (HTN). 1,4,5,11 Finally, intervention studies in alcoholics have almost invariably shown a significant decrease in BP with reduced or no alcohol exposure. 12Ϫ16 Several investigations on the mechanisms that underlie the link between chronic alcohol consumption and HTN have been conducted involving, as the candidate abnormalities genetic predisposition, 10 hyperdynamic circulation with high cardia...

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“…Elevation in PRA is a well known feature in alcoholics, generally thought to be a consequence of a stimulatory effect of alcohol on renin secretion, partly mediated via sympathetic nervous system and similar to that reproducible in healthy humans by an acute alcohol load (Bannan et al, 1984;Bezzegh et al, 1991). Such a stimulation has been often suggested to be involved in elevated BP in alcoholics (Kaysen and Noth, 1984;Potter and Beevers, 1984).…”

Section: Discussionmentioning

confidence: 93%

Sodium Sensitivity as a Main Determinant of Blood Pressure Changes during Early Withdrawal in Heavy Alcoholics

Gennaro

Vescovi

Barilli

et al. 2002

Alcoholism Clin & Exp Res

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α-Atrial natriuretic peptide, aldosterone secretion and plasma renin activity during ethanol withdrawal: a correlation with the onset of delirium tremens?

Cited by 21 publications

References 12 publications

Ethanol withdrawal increases oxidative stress and reduces nitric oxide bioavailability in the vasculature of rats

Ethanol withdrawal increases oxidative stress and reduces nitric oxide bioavailability in the vasculature of rats

Sodium Sensitivity of Blood Pressure in Long-Term Detoxified Alcoholics

Sodium Sensitivity as a Main Determinant of Blood Pressure Changes during Early Withdrawal in Heavy Alcoholics

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