α-Cyperone of Cyperus rotundus is an effective candidate for reduction of inflammation by destabilization of microtubule fibers in brain

Ali, Azam; Ghaffari, Seyed Mahmood; Riazi, Gholamhossein; Arab, Seyed Shahriar; Tavakol, Mohammad Mehdi; Pooyan, Shahriar

doi:10.1016/j.jep.2016.06.058

Cited by 34 publications

(13 citation statements)

References 38 publications

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“…5) (contained in the essential oil of C. rotundus) is effective against convulsion in behavioral and electrophysiological studies. Azimi et al [62] identified α-cyperone from C. rotundus as capable of interactions with tubulin and as a destabilizing agent of microtubule polymerization. This interaction results in reduction of inflammation, which could be beneficial for the treatment of inflammatory diseases such as Alzheimer's disease.…”

Section: Evidence-linked Plants and Active Metabolites Of Tbm Effectimentioning

confidence: 99%

“… Acteoside Inhibits β-amyloid Alzheimer’s disease, cognitive deficit [ 82 , 83 ] Costus speciosus (J.Koenig) Sm. Costunolide Inhibition of NFkappaB and MAPKinase activation Neuroinflammatory diseases [ 167 ] Curcuma longa L. Curcumin, demethoxycurcumin, bis-demethoxycurcumin Prevent acute neuroinflammation, mitochondrial dysfunction and apoptosis Neuroinflammation and memory impairment, Parkinson’s disease [ 50 , 51 ] Cyperus rotundus Vahl α-Cyperone, terpinen-4-ol Destabilization of microtubule fibers in brain Brain inflammation [ 61 , 62 ] Lantana camara L. Ursolic acid stearoyl glucoside Unknown Anxiety [ 272 ] Nigella sativa L. Thymoquinone Inhibits β-amyloid Alzheimer’s disease [ 288 ] Retrieved dopaminergic neurons Parkinson’s disease [ 257 ] Oroxylum indicum (L.) Benth. Apigenin, baicalein, baicalin, chrysin, hispidulin, oroxylin A Induce neuronal differentiation Disorder of nerve tissue development [ 144 ] Piper betel Blanco Hydroxychavicol Atenuate cytokines and both β- and γ-secretase Cognitive dysfunction, Alzheimer’s disease ...…”

Section: Cns-active Natural Productsmentioning

confidence: 99%

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Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Uddin

Zidorn

2020

Nat. Prod. Bioprospect.

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The majority of the population in Bangladesh uses traditional plant-based medicines to manage various ailments, including central nervous system (CNS) disorders. This review presents ethnobotanical information and relevant scientific studies on plants used in traditional healthcare for the management of various CNS disorders in Bangladesh. The information on the medicinal plants of Bangladesh effective against CNS disorders published in scientific journals, books, and reports was compiled from different electronic databases using specific key words. The present article provides comprehensive information on a total of 224 medicinal plant species belonging to 81 families used for the treatment of CNS disorders by the various peoples of Bangladesh. In total, we reviewed more than 290 relevant papers. In this study, leaves were found as the most often used plant organ, followed by roots, fruits, whole plants, barks, seeds, stems, rhizomes, and flowers. The Fabaceae family contributes the highest number of used species, followed by Rubiaceae, Lamiaceae, Cucurbitaceae, Vitaceae, Euphorbiaceae, Malvaceae, and Zingiberaceae. The most frequently used species (in decreasing order) are Asparagus racemosus, Centella asiatica, Stephania japonica, Aegle marmelos, Coccinia grandis, Tabernaemontana divaricata, Bacopa monnieri, Abroma augusta, and Scoparia dulcis. This review may serve as a starting point for a rational search for neuroactive natural products against CNS disorders within the Flora of Bangladesh. Graphic Abstract

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Section: Evidence-linked Plants and Active Metabolites Of Tbm Effectimentioning

confidence: 99%

Section: Cns-active Natural Productsmentioning

confidence: 99%

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Uddin

Zidorn

2020

Nat. Prod. Bioprospect.

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“…It has been reported to possess a variety of pharmacological activities. Azam Azimi et al found that α-Cyperone has a pronounced effect on the destabilization of microtubule fibers in brain via interacting with tublin ( Azimi et al, 2016 ). A study using LPS-treated RAW 264.7 macrophages observed significant anti-inflammatory actions after α-Cyperone intervention, which was related to NF-κB induced reduction of COX-2 and IL-6 expression ( Jung et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

α-Cyperone Confers Antidepressant-Like Effects in Mice via Neuroplasticity Enhancement by SIRT3/ROS Mediated NLRP3 Inflammasome Deactivation

et al. 2020

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α-Cyperone (Cy) is a major active compound of Cyperus rotundus that has various pharmacological activities. But whether Cy possesses antidepressant effect is unknown. In this study, we exposed mice to chronic unpredictable mild stress (CUMS) with or without intervention with Cy. Our results showed that Cy significantly improved the depressive phenotypes in sucrose preference test, tail suspension test and forced swimming test. Meanwhile, increased SIRT3 expression, reduced ROS production and activated NF-κB signal were detected in the hippocampus of mice. NLRP3 inflammasome related proteins including NLRP3, ASC, Caspase-1, IL-1β, IL-18 and GSDMD-N were downregulated after Cy administration. Synaptic proteins including Synapsin-1 and PSD-95 and dendritic spine density were improved after Cy treatment. Moreover, the protective effects of Cy in CUMS mice were compromised when co-administrated with SIRT3 inhibitor 3-TYP. Taken together, these findings suggested that Cy has therapeutic potential for treating depression and that this antidepressant effect may be attributed to SIRT3 stimulated neuroplasticity enhancement by suppressing NLRP3 inflammasome.

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“…a-Cyperone, extracted from Cyperus rotundus, has been demonstrated to weaken the inflammatory response by microtubule destabilization in the brain (Azimi et al, 2016). Sutalangka et al has reported Cyperus rotundus has neuroprotective and cognitive-enhancing effects in AF64A-treated rats (Sutalangka and Wattanathorn, 2017).…”

Section: Introductionmentioning

confidence: 99%

α-Cyperone Attenuates H2O2-Induced Oxidative Stress and Apoptosis in SH-SY5Y Cells via Activation of Nrf2

Huang

Liu

et al. 2020

Front. Pharmacol.

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a-Cyperone, extracted from Cyperus rotundus, has been reported to inhibit microgliamediated neuroinflammation. Oxidative stress and apoptosis play crucial roles in the course of Parkinson's disease (PD). PD is a common neurodegenerative disease characterized by selective death of dopaminergic neurons. This study was designed to investigate the neuroprotective effects of a-cyperone against hydrogen peroxide (H 2 O 2)induced oxidative stress and apoptosis in dopaminergic neuronal SH-SY5Y cells. Neurotoxicity was assessed by MTT assay and the measurement of lactic dehydrogenase (LDH) release. The level of reactive oxygen species (ROS) was measured by dichlorodihydrofluorescin diacetate (DCFH-DA) staining. The apoptosis of SH-SY5Y cells was evaluated by annexin-V-FITC staining. The translocation of NF-E2related factor 2 (Nrf2) was determined by western blot and immunofluorescence staining. Western blot analysis was conducted to determine the expression level of cleavedcaspase-3, the pro-apoptotic factor Bax, and the anti-apoptotic factor, Bcl-2. The results showed that a-cyperone substantially decreased H 2 O 2-induced death, release of LDH, and the production of ROS in SH-SY5Y cells. In addition, we found that a-cyperone attenuated H 2 O 2-induced cellular apoptosis. Moreover, a-cyperone remarkably reduced the expression of cleaved-caspase-3 and Bax, and upregulated Bcl-2. Furthermore, acyperone enhanced the nuclear translocation of Nrf2. Pretreatment with brusatol (BT, an Nrf2 inhibitor) attenuated a-cyperone-mediated suppression of ROS, cleaved-caspase-3, and Bax, as well as a-cyperone-induced Bcl-2 upregulation in H 2 O 2-treated SH-SY5Y cells. a-cyperone neuroprotection required Nrf2 activation. In conclusion, a-cyperone attenuated H 2 O 2-induced oxidative stress and apoptosis in SH-SY5Y cells via the activation of Nrf2, suggesting the potential of this compound in the prevention and treatment of PD.

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α-Cyperone of Cyperus rotundus is an effective candidate for reduction of inflammation by destabilization of microtubule fibers in brain

Cited by 34 publications

References 38 publications

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

α-Cyperone Confers Antidepressant-Like Effects in Mice via Neuroplasticity Enhancement by SIRT3/ROS Mediated NLRP3 Inflammasome Deactivation

α-Cyperone Attenuates H2O2-Induced Oxidative Stress and Apoptosis in SH-SY5Y Cells via Activation of Nrf2

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