α‐Glucosidase Inhibitory Activity of Bromophenol Purified from the Red Alga Polyopes lancifolia

Abstract

A bromophenol, bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, was purified from the red alga Polyopes lancifolia. Its IC(50) values were 0.098 and 0.120 microM against Saccharomyces cerevisiae and Bacillus stearothermophilus alpha-glucosidases, respectively, and 1.00 and 1.20 mM against rat-intestinal sucrase and maltase. This bromophenol competitively inhibited S. cerevisiae alpha-glucosidase with a K(I) value of 0.068 microM and was very stable at pH 2 for 60 min at 37 degrees C. Therefore, this P. lancifolia bromophenol may have potential as natural nutraceutical for the management of type 2 diabetes.

Methanol Extract of <i>Polyopes lancifolius</i> Inhibits the Expression of Pro-inflammatory Mediators in LPSstimulated BV2 Microglia Cells via Downregulation of the NF-&#954B Pathway

“…Therefore, many researchers are looking for more potent compounds with anti-inflammatory characteristics. Polyopes lancifolius, mainly found in the Republic of Korea and Japan, is such a seaweed with medicinal value [11]. Only one study has been conducted and this revealed that bromophenol purified from P. lancifolia, which was thought to be the same species as P. lancifolius, may have potential as a natural nutraceutical for treating type 2 diabetes [11].…”

Alpha-amylase, antioxidant, and anti-inflammatory activities of Eucheuma denticulatum (N.L. Burman) F.S. Collins and Hervey

“…Seaweed extracts are rich in phytochemicals such as polyphenols, phlorotannins, and phloroglucinol derivatives that have been shown to exhibit antidiabetic activity through inhibition of α-amylase and α-glucosidase activity (Lee et al 2009;Kim et al 2010). Besides inhibition of the carbohydrate-hydrolyzing enzymes, another important antidiabetic mechanism previously postulated is via antioxidant activity (Wang et al 2012).…”

Protective role of marine macroalgae extracts against STZ induced diabetic rats

“…Marine algae produce a wide range of new secondary metabolites with various biological activities which may have potential applicability in the field of pharmaceutical industry to provide a stable platform for medicine industries [15]. Several bioactive compounds from red algae such as Rhodomela confervoides, Symphyocladia latiuscula, Polysiphonia urceolata and brown marine algae have been experimentally tested for their biomedical efficacy [16][17][18].…”