α‐Lipoic acid prevents mild portal endotoxaemia‐induced hepatic inflammation and β cell dysfunction

Tian, Yufeng; Hsieh, Chang‐Hsun; Hsieh, Yen-Ju; Chen, Yuting; Peng, Yi‐Jen; Hsieh, Po‐Shiuan

doi:10.1111/j.1365-2362.2011.02630.x

Cited by 22 publications

(25 citation statements)

References 34 publications

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“…ALA acts through the TLR4 and NF-κB pathways and abrogates the effects of LPS challenge [125]. Cotreatment with ALA prevents the LPS-induced expression of TLR4, IL-6, and TNF-α [126]. Two substances glycyrrhizin (GL) and isoliquiritigenin (ILG) from the plant G. uralensis (Chinese licorice) suppress LPS-induced TLR4 signaling in different ways [127].…”

Section: Blocking Ros and Rns And Tlr4 Signalingmentioning

confidence: 99%

Role of the Toll Like Receptor (TLR) Radical Cycle in Chronic Inflammation: Possible Treatments Targeting the TLR4 Pathway

Lucas¹,

2013

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Activation of the Toll-like receptor 4 (TLR4) complex, a receptor of the innate immune system, may underpin the pathophysiology of many human diseases, including asthma, cardiovascular disorder, diabetes, obesity, metabolic syndrome, autoimmune disorders, neuroinflammatory disorders, schizophrenia, bipolar disorder, autism, clinical depression, chronic fatigue syndrome, alcohol abuse, and toluene inhalation. TLRs are pattern recognition receptors that recognize damage-associated molecular patterns and pathogen-associated molecular patterns, including lipopolysaccharide (LPS) from gram-negative bacteria. Here we focus on the environmental factors, which are known to trigger TLR4, e.g., ozone, atmosphere particulate matter, long-lived reactive oxygen intermediate, pentachlorophenol, ionizing radiation, and toluene. Activation of the TLR4 pathways may cause chronic inflammation and increased production of reactive oxygen and nitrogen species (ROS/RNS) and oxidative and nitrosative stress and therefore TLR-related diseases. This implies that drugs or substances that modify these pathways may prevent or improve the abovementioned diseases. Here we review some of the most promising drugs and agents that have the potential to attenuate TLR-mediated inflammation, e.g., anti-LPS strategies that aim to neutralize LPS (synthetic anti-LPS peptides and recombinant factor C) and TLR4/MyD88 antagonists, including eritoran, CyP, EM-163, epigallocatechin-3-gallate, 6-shogaol, cinnamon extract, N-acetylcysteine, melatonin, and molecular hydrogen. The authors posit that activation of the TLR radical (ROS/RNS) cycle is a common pathway underpinning many "civilization" disorders and that targeting the TLR radical cycle may be an effective method to treat many inflammatory disorders.

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Section: Blocking Ros and Rns And Tlr4 Signalingmentioning

confidence: 99%

Role of the Toll Like Receptor (TLR) Radical Cycle in Chronic Inflammation: Possible Treatments Targeting the TLR4 Pathway

Lucas¹,

2013

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“…As many mutagens act through the generation of reactive oxygen species (ROS), the removal of reactive molecules represents an important strategy in the process of antimutagenesis (Shay et al 2009; Tian et al 2012). There is increasing evidence that compounds with antioxidant properties can remove ROS before these molecules react with DNA, resulting in a mutation (Lee et al 2011; Tian et al 2012).…”

Section: Antimutagens With Antioxidant Potencymentioning

confidence: 99%

“…There is increasing evidence that compounds with antioxidant properties can remove ROS before these molecules react with DNA, resulting in a mutation (Lee et al 2011; Tian et al 2012). …”

Section: Antimutagens With Antioxidant Potencymentioning

confidence: 99%

Antimutagenic compounds and their possible mechanisms of action

et al. 2014

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Mutagenicity refers to the induction of permanent changes in the DNA sequence of an organism, which may result in a heritable change in the characteristics of living systems. Antimutagenic agents are able to counteract the effects of mutagens. This group of agents includes both natural and synthetic compounds. Based on their mechanism of action among antimutagens, several classes of compounds may be distinguished. These are compounds with antioxidant activity; compounds that inhibit the activation of mutagens; blocking agents; as well as compounds characterized with several modes of action. It was reported previously that several antitumor compounds act through the antimutagenic mechanism. Hence, searching for antimutagenic compounds represents a rapidly expanding field of cancer research. It may be observed that, in recent years, many publications were focused on the screening of both natural and synthetic compounds for their beneficial muta/antimutagenicity profile. Thus, the present review attempts to give a brief outline on substances presenting antimutagenic potency and their possible mechanism of action. Additionally, in the present paper, a screening strategy for mutagenicity testing was presented and the characteristics of the most widely used antimutagenicity assays were described.

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“…In these cases scavenging of the ROS seems to be the principal mechanism of antimutagenicity [36][37][38]. Lipoic acid (LA) is one such example which has shown potent antioxidant activity and also antimutagenicity against mitomycin-C induced mutations in human peripheral lymphocytes [39][40][41][42].…”

Section: Fruits and Vegetables As Dietary Sources Of Antimutagensmentioning

confidence: 99%

Fruits and Vegetables as Dietary Sources of Antimutagens

Gautam¹,

Saxena²,

Kumar³

2016

J Food Chem Nanotechnol

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Mutation is the process leading to heritable changes in the genetic material of an organism and caused mainly by the external factors, including chemical and physical agents, or can also occur spontaneously due to errors in DNA replication, repair, and recombination. Agents contributing to the mutagenic burden in the environment could be from industrial sources, wide spectrum applications of biocides in the agriculture, and other contaminants. As many of these mutagenic chemicals can induce severe disorders in humans including cancer and a large spectrum of inherited diseases, it is important to detect such mutagenic agents precisely and rapidly, and also look for an approach to combat them. Natural occurring dietary antimutagens primarily from health protective foods such as fruits and vegetables could provide a mechanism to counteract the deleterious effect of these mutagens. The World Health Organization (WHO) indicates that one-third of all cancer deaths are preventable and that diet is closely linked to cancer prevention. These health protective phytochemicals particularly antimutagenic ones could provide an effective solution to these concerns. The current review deals with understanding of the mutagenic events, methods of its analysis and a brief compilation of the existing scientific findings related to the dietary sources having potential to counteract the effects of the mutagenic exposures from different sources. The review would provide an opportunity to look into the science, think about the possible future perspectives and mechanism to translate the outcome of the scientific research for benefits of the mankind.

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α‐Lipoic acid prevents mild portal endotoxaemia‐induced hepatic inflammation and β cell dysfunction

Abstract: α-Lipoic acid cotreatment could significantly prevent mild portal endotoxaemia-induced chronic hepatic inflammation and impaired pancreatic insulin secretion in absence of changing systemic insulin resistance.

Cited by 22 publications

References 34 publications

Role of the Toll Like Receptor (TLR) Radical Cycle in Chronic Inflammation: Possible Treatments Targeting the TLR4 Pathway

Role of the Toll Like Receptor (TLR) Radical Cycle in Chronic Inflammation: Possible Treatments Targeting the TLR4 Pathway

Antimutagenic compounds and their possible mechanisms of action

Fruits and Vegetables as Dietary Sources of Antimutagens

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