α-Mangostin inhibits DMBA/TPA-induced skin cancer through inhibiting inflammation and promoting autophagy and apoptosis by regulating PI3K/Akt/mTOR signaling pathway in mice

Wang, Fei; Ma, Hongxia; Liu, Zhaoguo; Huang, Wei; Xu, Xiaojing; Zhang, Xuemei

doi:10.1016/j.biopha.2017.05.129

Cited by 66 publications

(39 citation statements)

References 66 publications

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“…α-mangostin (Fig. 1A), a natural xanthone isolated from the pericarps of mangosteen (Garcinia mangostma L), known as the “queen of fruits”, also has in vitro and in vivo activities against various human malignant cells, in addition to well-known anti-inflammatory, anti-oxidant, and anti-bacterial effects [8, 9]. α-mangostin appears to exert its anti-tumor effects by distinct mechanisms in different types of cancer cells; it induces cell cycle arrest and increases the levels of reactive oxygen species in breast cancer cells [10], it induces apoptosis in prostate cancer cells [11], and it inhibits proliferation and promotes apoptosis in gastric cancer cells [12].…”

Section: Introductionmentioning

confidence: 99%

Alpha-Mangostin Suppresses the Metastasis of Human Renal Carcinoma Cells by Targeting MEK/ERK Expression and MMP-9 Transcription Activity

Chen

Hsieh

Lin

et al. 2017

Cell Physiol Biochem

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Background/Aims: α-mangostin has anti-carcinogenic effects against several cancers. We investigated the molecular mechanism of this compound on the metastasis of human renal carcinoma cells. Methods: Cell viability was measured using the MTT assay, and cell cycle distribution using flow cytometry. A Matrigel-based assay was used to measure in vitro cell migration and invasion. MAPK-related proteins and matrix metalloproteinase (MMP)-9 and MMP-2 expression were measured by western blotting, and MMP2/-9 activities were determined by gelatin zymography. RT-qPCR and a luciferase assay were used to examine the transcriptional activity of MMP-9. Results: α-mangostin inhibited the migration and invasion of RCC cells in a dose-dependent manner, but had no evident cytotoxic effects. Treatment of 786-O cells with α-mangostin inhibited activation of MEK and ERK. Treatment with a specific MEK inhibitor (U0126) enhanced the inhibitory effects of α-mangostin on cell migration and invasion, and the phosphorylation of ERK and MEK. Moreover, α-mangostin inhibited the expression of the MMP-9 mRNA levels as well as the activity of MMP-9 promoter, and these suppressive effects were further enhanced by U0126. Conclusions: Our results suggest that α-mangostin suppresses cell migration and invasion via MEK/ERK/MMP9 pathway, and might be a promising anti-metastatic agent against human renal cell carcinoma.

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Section: Introductionmentioning

confidence: 99%

Alpha-Mangostin Suppresses the Metastasis of Human Renal Carcinoma Cells by Targeting MEK/ERK Expression and MMP-9 Transcription Activity

Chen

Hsieh

Lin

et al. 2017

Cell Physiol Biochem

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“…PI3K/AKT signaling pathway is an important signal transduction pathway in cells, through the activation of downstream mTOR, NF-kappa B pathway, induced inactivation of Caspase, cyclin related gene transcription or its transcriptional regulator of the formation and regulation of Bcl-2 family members Bcl-2, Bax and Bcl-XL etc. The balance of expression on cell proliferation and apoptosis play an important biological function of resistance (19)(20)(21)(22). P53 protein is an important downstream site of PI3K/AKT signaling pathway (23,24).…”

Section: Discussionmentioning

confidence: 99%

miRNA-489 as a biomarker in diagnosis and treatment of cervical cancer

Juan¹,

Hua²,

Ruping³

et al. 2018

BLL

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miRNA-489 was shown to be a suppressor factor in many cancers, however, evidence on the effects and mechanism of miRNA-489 in progression of cervical cancer is limited. So we aimed to determine the function of miRNA-489 in cervical cancer proliferation and apoptosis in our present study. Interestingly, we found that miRNA-489 was significantly down-regulated in cervical cancer tissues. miRNA-489 overexpression inhibited the cell proliferation and improved the cell apoptosis of cervical cancer cells. Further, miRNA-489 over-expression suppressed the activation of PI3K and AKT, and stimulated P53 proteins expression. In conclusion, our results suggested that miRNA-489 may be considered as a biomarker in cervical cancer and had suppressed the cell proliferation and stimulated cell apoptosis via PI3K/AKT/P53 signaling pathway (Fig. 5, Ref. 26). Text in PDF www.elis.sk.

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“…Wang et al also reported the promotion of autophagy and apoptosis through the inhibition of the PI3K/Akt/mTOR pathway and the inhibition of inflammation by α-mangostin (5 and 20 mg/kg, i.p., daily) in mice with DMBA/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin cancer. In this way, treatment with xanthone suppressed the tumor growth and reduced the incidence rate of tumors in mice [310]. Conversely, another study suggested a different effect exerted by α-mangostin in modulating autophagy in CML cells.…”

Section: Xanthonesmentioning

confidence: 92%

Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies

Benvenuto

Albonici

Focaccetti

et al. 2020

IJMS

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One of the hallmarks of cellular transformation is the altered mechanism of cell death. There are three main types of cell death, characterized by different morphological and biochemical features, namely apoptosis (type I), autophagic cell death (type II) and necrosis (type III). Autophagy, or self-eating, is a tightly regulated process involved in stress responses, and it is a lysosomal degradation process. The role of autophagy in cancer is controversial and has been associated with both the induction and the inhibition of tumor growth. Autophagy can exert tumor suppression through the degradation of oncogenic proteins, suppression of inflammation, chronic tissue damage and ultimately by preventing mutations and genetic instability. On the other hand, tumor cells activate autophagy for survival in cellular stress conditions. Thus, autophagy modulation could represent a promising therapeutic strategy for cancer. Several studies have shown that polyphenols, natural compounds found in foods and beverages of plant origin, can efficiently modulate autophagy in several types of cancer. In this review, we summarize the current knowledge on the effects of polyphenols on autophagy, highlighting the conceptual benefits or drawbacks and subtle cell-specific effects of polyphenols for envisioning future therapies employing polyphenols as chemoadjuvants.

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α-Mangostin inhibits DMBA/TPA-induced skin cancer through inhibiting inflammation and promoting autophagy and apoptosis by regulating PI3K/Akt/mTOR signaling pathway in mice

Cited by 66 publications

References 66 publications

Alpha-Mangostin Suppresses the Metastasis of Human Renal Carcinoma Cells by Targeting MEK/ERK Expression and MMP-9 Transcription Activity

Alpha-Mangostin Suppresses the Metastasis of Human Renal Carcinoma Cells by Targeting MEK/ERK Expression and MMP-9 Transcription Activity

miRNA-489 as a biomarker in diagnosis and treatment of cervical cancer

Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies

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