α- (phenylselanyl) acetophenone mitigates reserpine-induced pain–depression dyad: Behavioral, biochemical and molecular docking evidences

Sousa, Fernanda Severo Sabedra; Birmann, Paloma T.; Baldinotti, Rodolfo; Fronza, Mariana G.; Balaguez, Renata A.; Alves, Diego; Brüning, César Augusto; Savegnago, Lucielli

doi:10.1016/j.brainresbull.2018.07.007

Cited by 33 publications

(18 citation statements)

References 44 publications

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“…According to reports, in rodents, reserpine can cause hypofunction, motor stereotypes, dyskinesias, lethargy, and anhedonia [25][26][27][28][29]. After intraperitoneal injection of reserpine for three consecutive days, the mice showed symptoms of reduced mobility, desperation and anhedonia, which is consistent with the results reported in the literature, indicating that the model was successfully constructed.…”

Section: Discussionsupporting

confidence: 89%

A Reliable High-Throughput Screening Model for Antidepressant

Zhang

Qiao

Liu

et al. 2021

IJMS

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Depression is the most frequent affective disorder and is the leading cause of disability worldwide. In order to screen antidepressants and explore molecular mechanisms, a variety of animal models were used in experiments, but there is no reliable high-throughput screening method. Zebrafish is a common model organism for mental illness such as depression. In our research, we established chronic unpredictable mild stress (CUMS) models in C57BL/6 mice and zebrafish; the similarities in behavior and pathology suggest that zebrafish can replace rodents as high-throughput screening organisms. Stress mice (ip., 1 mg/kg/d, 3 days) and zebrafish (10 mg/L, 20 min) were treated with reserpine. As a result, reserpine caused depression-like behavior in mice, which was consistent with the results of the CUMS mice model. Additionally, reserpine reduced the locomotor ability and exploratory behavior of zebrafish, which was consistent with the results of the CUMS zebrafish model. Further analysis of the metabolic differences showed that the reserpine-induced zebrafish depression model was similar to the reserpine mice model and the CUMS mice model in the tyrosine metabolism pathway. The above results showed that the reserpine-induced depression zebrafish model was similar to the CUMS model from phenotype to internal metabolic changes and can replace the CUMS model for antidepressants screening. Moreover, the results from this model were obtained in a short time, which can shorten the cycle of drug screening and achieve high-throughput screening. Therefore, we believe it is a reliable high-throughput screening model.

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Section: Discussionsupporting

confidence: 89%

A Reliable High-Throughput Screening Model for Antidepressant

Zhang

Qiao

Liu

et al. 2021

IJMS

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“…Reserpine administration improves anxiety and depressive-like behaviors shown by mice staying at the edge of the space in OFT and maintaining immobility in TST and FST (Chang et al, 2015). This induced symptom effectively relieves anxiety and depressive symptoms, such as increased crossing and decreased immobility by antidepressant-like PSAP and herbal medicines (Sousa et al, 2018;Park et al, 2020). This study found that reserpineadministered mice exhibited reduced central dwelling time and entry frequency in the OFT as well as increased immobility in the TST and FST.…”

Section: Discussionsupporting

confidence: 50%

Antidepressant and Anxiolytic-Like Effects of the Stem Bark Extract of Fraxinus rhynchophylla Hance and Its Components in a Mouse Model of Depressive-Like Disorder Induced by Reserpine Administration

Kim

Park

Seo

et al. 2021

Front. Behav. Neurosci.

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There is an urgent need to find antidepressants that can be administered for long periods without inducing severe side effects to replace conventional antidepressants that control monoamine levels, such as tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs), and selective serotonin reuptake inhibitors (SSRI). We sought to determine the antidepressant effects of Fraxinus rhynchophylla Hance (F. rhynchophylla Hance, FX) and its components on a reserpine-induced mouse model. One hour after oral administration of FX (30, 50, and 100 mg/kg), esculin (50 mg/kg), esculetin (50 mg/kg), fraxin (50 mg/kg), and fluoxetine (20 mg/kg), reserpine was delivered intraperitoneally to mice. Behavioral experiments were conducted to measure anxiety and depressive-like behaviors after 10 days of administration. FX and its components increased the number of entries into the center of an open field as well as distance traveled within it and decreased immobility duration in the forced swim and tail suspension tests. Reserpine-induced increases in plasma corticosterone concentrations were attenuated by the administration of FX and its components, which were also found to decrease the reserpine-induced enhancement of mRNA levels of interleukin (IL)-12 p40, IL-6, and tumor necrosis factor (TNF)-α, pro-inflammatory cytokines. Finally, the diminished expressions of hippocampal phosphorylated cAMP response element-binding protein (pCREB) and brain-derived neurotrophic factor (BDNF) by reserpine were increased by FX and its components. Our results suggest that FX and its components regulate anxiety and depressive-like behaviors through stress hormones, immune regulation, and the activation of neuroprotective mechanisms, further supporting the potential of FX and its components as antidepressants.

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“…For instance, a traditional Korean medicine called Gyejibokryeong-hwan (GBH) has been reported to potentially regulate immune/endocrine dysfunction in mice to mitigate depression via activating the BDNF-cAMP-response element binding protein (CREB) pathway [26]. α-(phenylselanyl) acetophenone (PSAP), which is an organic selenium compound with antioxidant characteristics, can reverse the pain-mediated depression induced by reserpine via inhibiting type-A monoamine oxidase (MAO-A) [27]. Cocaine and amphetamines, as two blockers of monoamine reuptake, may produce agitation rather than a mood-relief effect in patients with severe depression [28].…”

Section: Depression Modeling Approachesmentioning

confidence: 99%

Selecting an Appropriate Animal Model of Depression

Hao

Sun

et al. 2019

IJMS

174

112

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Depression has become one of the most severe psychiatric disorders and endangers the health of living beings all over the world. In order to explore the molecular mechanism that underlies depression, different kinds of animal models of depression are used in laboratory experiments. However, a credible and reasonable animal model that is capable of imitating the pathologic mechanism of depression in mankind has yet to be found, resulting in a barrier to further investigation of depression. Nevertheless, it is possible to explain the pathologic mechanism of depression to a great extent by a rational modeling method and behavioral testing. This review aims to provide a reference for researchers by comparing the advantages and disadvantages of some common animal depression models.

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α- (phenylselanyl) acetophenone mitigates reserpine-induced pain–depression dyad: Behavioral, biochemical and molecular docking evidences

Cited by 33 publications

References 44 publications

A Reliable High-Throughput Screening Model for Antidepressant

A Reliable High-Throughput Screening Model for Antidepressant

Antidepressant and Anxiolytic-Like Effects of the Stem Bark Extract of Fraxinus rhynchophylla Hance and Its Components in a Mouse Model of Depressive-Like Disorder Induced by Reserpine Administration

Selecting an Appropriate Animal Model of Depression

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