α-Zein nanoparticles as delivery systems for hydrophobic compounds: Effect of assembly parameters

Sánchez-Juárez, C.; Reyes‐Duarte, Dolores; Hernández-Guerrero, M.; Morales-Ibarría, Marcia; Campos‐Terán, José; Arroyo‐Maya, Izlia J.

doi:10.24275/rmiq/alim859

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…The process is facilitated by the increased polarity upon the addition of water, which causes the hydrophilic ends of zein to orient towards the aqueous environment and the hydrophobic regions to align towards the interior of the Nps. This orientation forms a protective niche for the hydrophobic compounds [32,33]. Given the pronounced hydrophilic nature of LIRA, its interaction with zein is impaired during Nps formation.…”

Section: Development Of Zein/eudragit-chitosan Nanoparticles Containi...mentioning

confidence: 99%

Oral Delivery of Liraglutide-Loaded Zein/Eudragit-Chitosan Nanoparticles Provides Pharmacokinetic and Glycemic Outcomes Comparable to Its Subcutaneous Injection in Rats

Ziebarth,

da Silva,

Lorenzett

et al. 2024

Pharmaceutics

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Liraglutide (LIRA) is a glucagon-like peptide-1 (GLP-1) receptor agonist renowned for its efficacy in treating type 2 diabetes mellitus (T2DM) and is typically administered via subcutaneous injections. Oral delivery, although more desirable for being painless and potentially enhancing patient adherence, is challenged by the peptide’s low bioavailability and vulnerability to digestive enzymes. This study aimed to develop LIRA-containing zein-based nanoparticles stabilized with eudragit RS100 and chitosan for oral use (Z-ERS-CS/LIRA). These nanoparticles demonstrated a spherical shape, with a mean diameter of 238.6 nm, a polydispersity index of 0.099, a zeta potential of +40.9 mV, and an encapsulation efficiency of 41%. In vitro release studies indicated a prolonged release, with up to 61% of LIRA released over 24 h. Notably, the nanoparticles showed considerable resistance and stability in simulated gastric and intestinal fluids, suggesting protection from pH and enzymatic degradation. Pharmacokinetic analysis revealed that orally administered Z-ERS-CS/LIRA paralleled the pharmacokinetic profile seen with subcutaneously delivered LIRA. Furthermore, in vivo tests on a diabetic rat model showed that Z-ERS-CS/LIRA significantly controlled glucose levels, comparable to the results observed with free LIRA. The findings underscore Z-ERS-CS/LIRA nanoparticles as a promising approach for oral LIRA delivery in T2DM management.

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Section: Development Of Zein/eudragit-chitosan Nanoparticles Containi...mentioning

confidence: 99%

Oral Delivery of Liraglutide-Loaded Zein/Eudragit-Chitosan Nanoparticles Provides Pharmacokinetic and Glycemic Outcomes Comparable to Its Subcutaneous Injection in Rats

Ziebarth,

da Silva,

Lorenzett

et al. 2024

Pharmaceutics

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Improving the biological activities of astaxanthin using targeted delivery systems

Cai

Gan

Regenstein

et al. 2023

Critical Reviews in Food Science and Nutrition

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α-Zein nanoparticles as delivery systems for hydrophobic compounds: Effect of assembly parameters

Abstract: Modelado de la biodegradación en biorreactores de lodos de hidrocarburos totales del petróleo intemperizados en suelos y sedimentos (Biodegradation modeling of sludge bioreactors of total petroleum hydrocarbons weathering in soil and sediments)

Cited by 2 publications

References 21 publications

Oral Delivery of Liraglutide-Loaded Zein/Eudragit-Chitosan Nanoparticles Provides Pharmacokinetic and Glycemic Outcomes Comparable to Its Subcutaneous Injection in Rats

Oral Delivery of Liraglutide-Loaded Zein/Eudragit-Chitosan Nanoparticles Provides Pharmacokinetic and Glycemic Outcomes Comparable to Its Subcutaneous Injection in Rats

Improving the biological activities of astaxanthin using targeted delivery systems

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