α1-Antitrypsin and fibromyalgia: new data in favour of the inflammatory hypothesis of fibromyalgia

Blanco, lgnacio Eduardo; Serres, Frederick J. de; Fernández-Bustillo, Enrique; Kassam, Daniel Al; Arbesú, Daniel; Rodríguez, Carmen; Torre, Juan Carlos Gómez de la

doi:10.1016/j.mehy.2004.10.005

Cited by 34 publications

(26 citation statements)

References 41 publications

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“…As an inhibitor of elastase, AAT inhibits also the neointima formation in the smalldiameter artheries [16]. AAT has anti-inflammatory effect, preventing inflammatory reactions, especially in soft tissues [29]. Lowered activities of AAT were found in the group of IUGR women may be connected with the incorrect reconstruction of small vessels wall in utero-placental circulation system during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Indices of oxidative stress in pregnancy with fetal growth restriction

Karowicz-Bilińska

Kędziora–Kornatowska²,

Bartosz

2007

Free Radical Research

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Intrauterine fetal growth restriction (IUGR), the main cause of premature delivery and fetal mortality, has been suggested to involve oxidative stress. We found elevated values of indices of oxidative stress in the blood serum of pregnant women with IUGR: increased levels of malondialdehyde and 4-hydroxyalkenals, decreased activity of alpha-1-antitrypsin and decreased total antioxidant capacity of the serum, with respect to healthy pregnancy. Twenty day treatment with 3 g of l-arginine and 75 mg of acetylsalicylic acid daily resulted in a decrease of the level of lipid peroxidation products and augmentation of alpha-1-antitrypsin activity. This study confirms the occurrence of oxidative stress in IUGR and demonstrates the beneficial effect of arginine/acetylsalicylic acid therapy in reducing oxidative stress in IUGR.

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Section: Discussionmentioning

confidence: 99%

Indices of oxidative stress in pregnancy with fetal growth restriction

Karowicz-Bilińska

Kędziora–Kornatowska²,

Bartosz

2007

Free Radical Research

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“…Furthermore, the number of tender points has been found to be correlated with depressive symptoms such as depressed mood, fatigue, disability, pain, and somatic symptoms 14 . In addition, although the precise cause of FM remains unclear, it is known to involve several factors including altered pain processing 15 and neuromodulation 16 and abnormalities in immune system function 17 , neurotransmitter regulation 18,19 , response to stress 20 , autonomic nervous system function 21 , and various psychosocial factors such as early adversity 22 that are also implicated in MDD.…”

Section: Introductionmentioning

confidence: 99%

The relationship between fibromyalgia and major depressive disorder: a comprehensive review

Pae

Luyten

Marks

et al. 2008

Current Medical Research and Opinion

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“…Additionally, a possible relationship between Z-ATD and FMS recently has been reported, and an inflammatory hypothesis for FMS has been documented (14, 15).…”

Section: Introductionmentioning

confidence: 99%

Alpha1-Antitrypsin Polymorphism in Fibromyalgia Syndrome Patients from the Asturias Province in Northern Spain: A Significantly Higher Prevalence of the PI*Z Deficiency Allele in Patients Than in the General Population

Blanco

Arbesú

Kassam

et al. 2006

Journal of Musculoskeletal Pain

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Background: Recent evidence suggests that the alpha1-antitrypsin [AT] gene may play a role in the pathogenesis of the fibromyalgia syndrome [FMS]. The objective of the present study is to compare the AT gene frequency between FMS patients and the general population [GP] from the central region of the Asturias Province in Northern Spain.Method: The AT proteinase inhibitor phenotypes were characterized by isoelectric focusing on serum from a cohort of 250 individual FMS subjects, who fulfilled the American College of Rheumatology criteria for FMS, and on serum from a control cohort of 1,111 GP subjects. The FMS subjects [238 females and 12 males] were enlisted from an outpatient hospital clinic setting. The mean age of the FMS cohort was of 49.02 years. The GP control cohort [45 percent males and 55 percent females] was enrolled using an epidemiological technique of simple random sampling in the general population from the same region of Asturias. The GP sample size was 1,111, the mean age was of 46.2 years. Mean outcome measures were AT-PI phenotyping characterization [performed by isoelectric focusing] and AT serum concentration [measured by nephelometry]. Results: Calculated mean allele frequencies for PI*S and PI*Z [the two most frequent AT deficiency alleles] were 64 [95 percent confidence interval [CI]: 45-90] and 40 [CI: 25-62] per 1,000, respectively, for the FMS cohort, as compared with 100 [CI: 88-113] and 19.7 [CI: 14.5-26.6] per 1,000 for the GP cohort. Calculated prevalences [Hardy-Weinberg statistics formula] were 1/14 in FMS versus 1/29 in GP for MZ; 1/195 in FMS versus 1/254 in GP for SZ; and 1/625 in FMS versus 1/2,573 in GP for ZZ. For PI*Z, the calculated odd ratio among FMS versus GP was 2.06 [CI: 1.16-3.63]. A binomial proof [contrast hypothesis] stated that FMS AT-Z gene frequency differed significantly from the GP Z gene frequency [P = 0.007].Conclusion: The most common AT severe-deficient allele [i.e., PI*Z] has been found with a two-fold higher frequency in the FMS cohort than in the GP cohort. The high odds ratio found for PI*Z indicates a significant difference for PI*Z frequency in the FMS cohort as compared with the GP cohort. Our findings suggest that AT deficiency might play an important role in FMS development and clinical expression in, at least, a subset of FMS subjects.

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α1-Antitrypsin and fibromyalgia: new data in favour of the inflammatory hypothesis of fibromyalgia

Cited by 34 publications

References 41 publications

Indices of oxidative stress in pregnancy with fetal growth restriction

Indices of oxidative stress in pregnancy with fetal growth restriction

The relationship between fibromyalgia and major depressive disorder: a comprehensive review

Alpha1-Antitrypsin Polymorphism in Fibromyalgia Syndrome Patients from the Asturias Province in Northern Spain: A Significantly Higher Prevalence of the PI*Z Deficiency Allele in Patients Than in the General Population

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