α1-antitrypsin excretion in stool in normal subjects and in patients with gastrointestinal disorders

Strygler, Bernardo; Nicar, Michael J.; Santangelo, William C.; Porter, Jack L.; Fordtran, John S.

doi:10.1016/0016-5085(90)91165-3

Cited by 107 publications

(45 citation statements)

References 17 publications

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“…17 Another report on 70 healthy 3-month-old babies also revealed no difference in fecal calprotectin levels between exclusively BF and FF babies (P=0.09). 18 In addition, another study on 160 healthy babies who were either exclusively BF or received prebiotic/probiotic supplemented formula revealed no significant difference in fecal calprotectin level between the first sampling (< 6 weeks of age) and at second (3 months later) (P=0.393). 12 our study could not be compared to previous studies due to differences in age intervals of the subjects, thus the result consistently showed a higher level of fecal calprotectin in FF babies.…”

Section: Discussionmentioning

confidence: 96%

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Gut wall integrity in exclusively breastfed vs. formula-fed infants

Hayati

Kadim

Mangunatmadja

et al. 2016

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Section: Discussionmentioning

confidence: 96%

“…Higher fecal AAT level shows greater gut wall permeability which cause greater protein enteric loss. 12,18 However, using AAT measurements to assess gut wall integrity in infants has had varied results. We found a significantly higher mean AAT level in the BF group compared to the FF group (P=0.02).…”

Section: Discussionmentioning

confidence: 99%

Gut wall integrity in exclusively breastfed vs. formula-fed infants

Hayati

Kadim

Mangunatmadja

et al. 2016

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“…17,20,23 Factors other than enteric protein loss may play an important role in determining serumal albumin concentration in humans affected with gastrointestinal disease. 32 These factors include the rate of synthesis of albumin, which is determined by nutritional status, the rate of extraintestinal catabolism, and contraction of plasma volume.…”

Section: Clinical and Clinicopathologic Features Of Horses With Gementioning

confidence: 99%

Chronic Idiopathic Inflammatory Bowel Diseases of the Horse

Schumacher

Edwards

Cohen

2000

Veterinary Internal Medicne

101

180

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A review of reported cases of inflammatory bowel diseases (IBDs) of horses for which no etiology was identified included cases of granulomatous enteritis (GE), multisystemic eosinophilic epitheliotropic disease (MEED), lymphocytic-plasmacytic enterocolitis (LPE), and idiopathic eosinophilic enterocolitis (EC). The terms EC and MEED were both used to describe a disease in horses characterized by infiltration of intestine and extraintestinal tissues with eosinophils. We use EC to describe IBD characterized by only intestinal infiltration by eosinophils. Horses with GE, MEED, or LPE are usually examined because of weight loss and depression, but horses with EC are usually examined because of signs of abdominal pain. Typically, horses with IBD have low concentrations of serumal proteins, especially albumin, and fail to adequately absorb glucose or xylose. Antemortem diagnosis of IBD can only be made by histologic examination of affected intestine. In some cases, antemortem diagnosis is made from histologic examination of rectal mucosa obtained by biopsy. Suspected causes of IBD in the horse include abnormal immune response to bacterial, viral, parasitic, or dietary antigens. Most horses with IBD do not survive, but horses with EC are more likely than those with LPE, MEED, or GE to respond to treatment. Successful treatments of horses with IBD include resection of grossly affected intestine and administration of corticosteroids.Key words: Eosinophilic enterocolitis; Granulomatous enteritis; Lymphocytic-plasmacytic enterocolitis; Multisystemic eosinophilic epitheliotropic disease.C hronic inflammatory bowel diseases (IBDs) are associated with dysfunction of the gastrointestinal tract due to infiltration of the mucosa and submucosa with populations of eosinophils, plasma cells, lymphocytes, basophils, or macrophages. 1,2 Clinical signs of IBD in the horse include weight loss, dependent edema, and lethargy and are usually associated with protein-losing enteropathy and malabsorption of nutrients, including glucose. Affected horses may have diarrhea or signs of abdominal pain. Signalment, clinical signs, clinicopathologic findings, and postmortem lesions may be highly characteristic of some types of IBD in the horse, but, in general, clinical and gross pathologic features of these diseases are similar, and a final morphologic diagnosis is based on histologic examination. When an etiologic diagnosis of IBD has been reported, mycobacterial 3-12 or parasitic infections, 13,14 or toxins 15 have been identified. The purpose of this report is to describe distinguishing features and discuss possible etiologies of the idiopathic IBDs and to discuss treatment of affected horses. Granulomatous Enteritis (GE)This idiopathic condition was 1st reported in 1974 by Cimprich, 7 who noted the histologic similarity between this disease and Crohn's disease in humans. In our review of the reports of idiopathic GE, we found detailed descriptions of 47 affected horses. 6,7,9,[16][17][18][19][20][21][22][23][24][25] Of these, 32 were Standardbr...

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“…В настоящее время для верификации потерь белка через желудочно-кишечный тракт использу-ется определение содержания в кале α 1 -антитрип-сина -эндогенного белка, молекулярная масса которого близка к массе альбумина [25]. В норме α 1 -антитрипсин не секретируется клетками желу-дочно-кишечного тракта, не всасывается и не пере-варивается, устойчив в кале при температуре 37°C и не экскретируется с мочой.…”

Section: экссудативная энтеропатия вследствие повреждения слизистых жunclassified