β-2-Himachalen-6-ol inhibits 4T1 cells-induced metastatic triple negative breast carcinoma in murine model

Daaboul, Hamid Elia; Dagher, Carole; Taleb, Robin I.; Bodman‐Smith, Kikki; Shebaby, Wassim N.; El‐Sibai, Mirvat; Mroueh, Mohamad; Daher, Costantine F.

doi:10.1016/j.cbi.2019.06.016

Cited by 11 publications

(4 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As previously cited in this review, D. carota ssp. carota has a longstanding traditional use in Lebanon to fight oncological ailments, a usage substantiated by numerous studies underscoring its significant anticancer properties, attributed mainly to the presence of the distinctive compound β-2-himachalen-6-ol [ 25 , 37 , 64 , 65 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 ]. The wild carrot has also been traditionally employed by the Lebanese and Persian communities in the treatment of gastric ulcers [ 40 , 43 ], as supported by a study indicating that both aqueous and methanolic extracts possess protective effects against ethanol-induced gastric damage in rats.…”

Section: Discussionmentioning

confidence: 99%

“…A Western blot analysis showed that β-2-himachalen-6-ol upregulated the p53, p21, and BAX proteins while downregulating the Bcl-2, procaspase-3, and PARP proteins. In 2019, Daaboul et al [ 96 ] revealed that β-2-himachalen-6-ol treatment caused a dose-dependent decrease in cytotoxicity, induced cell cycle arrests, and promoted apoptosis in murine breast cancer cell line 4T1, along with a reduction in the primary tumor size and an inhibition of metastasis in mice. Thus, the aforementioned literature provides enough evidence to support the claimed traditional anticancer use of D. carota ssp.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

“…Furthermore, a study using a 1,2-dimethylhydrazine (DMH) colon carcinogenesis model in six black mice found that HC did not cause significant liver toxicity at doses of 10 and 25 mg/kg, while moderate hepatotoxicity was observed at a concentration of 50 mg/kg [ 94 ]. Daaboul et al [ 93 , 96 ] also reported that no body weight changes were observed after HC treatment in contrast to cisplatin, which exhibited significant weight reductions in the animals. No variations in liver enzyme profiles were reported after HC treatment, indicating no hepatotoxicity.…”

Section: Safety/toxicological Evaluationmentioning

confidence: 99%

See 2 more Smart Citations

The Wild Carrot (Daucus carota): A Phytochemical and Pharmacological Review

Ismail,

Shebaby,

Daher

et al. 2023

Plants

Self Cite

View full text Add to dashboard Cite

Daucus carota L., a member of the Apiaceae family, comprises 13 subspecies, with one being cultivated (D. carota L. ssp. sativus (Hoffm.) Arcang.) and the remaining being wild. Traditionally, the wild carrot has been recognized for its antilithic, diuretic, carminative, antiseptic, and anti-inflammatory properties and has been employed in the treatment of urinary calculus, cystitis, gout, prostatitis, and cancer. While extensive literature is available on the phytochemical, pharmacological, and therapeutic evaluations of the cultivated carrot, limited information has been published on the wild carrot. A thorough search was conducted on the phytochemical composition, folk-medicine uses, and pharmacological properties of wild carrot subspecies (Daucus carota L. ssp. carota). Various electronic databases were consulted, and the literature spanning from 1927 to early 2023 was reviewed. Thirteen wild Daucus carota subspecies were analyzed, revealing over 310 compounds, including terpenoids, phenylpropenoids, flavonoids, and phenolic acids, with 40 constituting more than 3% of the composition. This review also highlights the antioxidant, anticancer, antipyretic, analgesic, antibacterial, antifungal, hypolipidemic, and hepato- and gastroprotective properties of wild carrot subspecies. Existing in vitro and in vivo studies support their traditional uses in treating infections, inflammation, and cancer. However, further research on other subspecies is required to confirm additional applications. Well-designed preclinical and clinical trials are still necessary to establish the safety and efficacy of wild Daucus carota for human use.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Pharmacological Activitiesmentioning

confidence: 99%

Section: Safety/toxicological Evaluationmentioning

confidence: 99%

See 1 more Smart Citation

The Wild Carrot (Daucus carota): A Phytochemical and Pharmacological Review

Ismail,

Shebaby,

Daher

et al. 2023

Plants

Self Cite

View full text Add to dashboard Cite

show abstract

“…As previously reported, flavonoids could increase VEGF expression in oral aphthous ulcers, new blood cell formation, and pseudotubule formation in the aortic ring test. 8,9,12,[15][16][17][18] Therefore, we aimed to determine the role of forest honey administration on VEGF expression for wound healing in a palatoplasty model in Sprague Dawley.…”

Section: Introductionmentioning

confidence: 99%

Wound healing induces VEGF expression stimulated by forest honey in palatoplasty Sprague Dawley

et al. 2023

View full text Add to dashboard Cite

Background: Cleft palate is a craniofacial disorder with definitive therapy using the V–Y pushback technique palatoplasty, which has the impact of leaving the bone exposed on the palate with long wound healing and a high risk of infection. Forest honey has high antioxidants and the ability to accelerate wound healing. Purpose: This study aims to determine the effect of forest honey on vascular endothelial growth factor (VEGF) expression to accelerate the wound healing process after palatoplasty biopsy. Methods: Posttest only control group design using Sprague Dawley palatoplasty was performed on 15 rats which were divided into three groups, namely the honey treatment (KP), Aloclair as a positive control (KPP), and aquadest as a negative control (KKN). As much as 25 mg of honey was given therapeutically, and VEGF expression analysis post-biopsy palatoplasty was measured using the ELISA test. ANOVA analysis was carried out to determine the significant differences between each treatment, and in silico analysis was conducted to determine the compounds’ role in honey on the mechanism of VEGF expression. Results: Statistical analysis of VEGF expression in the KP group was 41.10 ng/ml ± 0.26, the KKP was 39.57 ± 0.27, while the KKN was 33.26 ± 0.62 (p≤ 0.01). In silico study, genistein (C15H10O5) targets several signaling pathways such as PI3K-Akt, AMPK, and mTOR, affecting accelerated proliferation and angiogenesis. Conclusion: In wound healing acceleration, forest honey induced VEGF expression through the genistein mechanism of angiogenesis and cell proliferation.

show abstract