β-Adrenergic modulation of cancer cell proliferation: available evidence and clinical perspectives

Coelho, Marisa; Soares-Silva, Cátia; Brandão, Daniela; Marino, Franca; Cosentino, Marco; Ribeiro, Laura

doi:10.1007/s00432-016-2278-1

Cited by 78 publications

(61 citation statements)

References 97 publications

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“…While the involvement of cAMP/PKA signaling in cancer development and prognosis has long been established, the associations of EPAC proteins, particularly EPAC1, with cancer are emerging and have been summarized in a recent review (15). In general, EPAC and PKA mediated signaling pathways function antagonistically, independently or synergistically in rare occasions to modulate cancer cell proliferation, apoptosis, adhesion, and migration (193,361,473,474,722,1030,1073). Activation of cAMP/EPAC1 signaling pathways has also been reported to sensitize refractory cancer cells to oncolytic virotherapy (605,606).…”

Section: B Role Of Epac In Cancersmentioning

confidence: 99%

Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development

Robichaux

Cheng

2018

Physiological Reviews

162

226

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This review focuses on one family of the known cAMP receptors, the exchange proteins directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide exchange factors (cAMP-GEFs). Although EPAC proteins are fairly new additions to the growing list of cAMP effectors, and relatively "young" in the cAMP discovery timeline, the significance of an EPAC presence in different cell systems is extraordinary. The study of EPACs has considerably expanded the diversity and adaptive nature of cAMP signaling associated with numerous physiological and pathophysiological responses. This review comprehensively covers EPAC protein functions at the molecular, cellular, physiological, and pathophysiological levels; and in turn, the applications of employing EPAC-based biosensors as detection tools for dissecting cAMP signaling and the implications for targeting EPAC proteins for therapeutic development are also discussed.

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Section: B Role Of Epac In Cancersmentioning

confidence: 99%

Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development

Robichaux

Cheng

2018

Physiological Reviews

162

226

View full text Add to dashboard Cite

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“…), and (2) to stimulate tumour cell proliferation, via beta (β) adrenergic receptors on tumour cells (Coelho et al. ). As since all of these processes are mediated via adrenergic receptors, the effects of β adrenergic blocking as a potential anti‐tumour therapy have been investigated in in vitro , animal, and retrospective patient studies with promising results (Magnon et al.…”

Section: Discussionmentioning

confidence: 99%

Sympathetic nerve tissue in milky spots of the human greater omentum

et al. 2019

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Omental milky spots (OMSs), small lymphoid structures positioned in the greater omentum, are involved in peritoneal immune homeostasis and the formation of omental metastases. Sympathetic nerve activity is known to regulate immune function in other lymphoid organs (e.g. spleen and lymph nodes) and to create a favourable microenvironment for various tumour types. However, it is still unknown whether OMSs receive sympathetic innervation. Therefore, the aim of this study was to establish whether OMSs of the adult human greater omentum receive sympathetic innervation. A total of 18 OMSs were isolated from five omenta, which were removed from 3% formaldehyde‐perfused cadavers (with a median age of 84 years, ranging from 64 to 94). OMSs were embedded in paraffin, cut and stained with a general (PGP9.5) and sympathetic nerve marker (TH and DBH), and evaluated by bright field microscopy. A T‐cell, B‐cell, and macrophage staining was performed to confirm OMS identity. In 50% of the studied OMSs, sympathetic nerve fibres were observed at multiple levels of the same OMS. Nerve fibres were represented as dots or elongated structures and often observed in relation to small vessels and occasionally as individual structures residing between lymphoid cells. The current study shows that 50% of the investigated OMSs contain sympathetic nerve fibres. These findings may contribute to our understanding of neural regulation of peritoneal immune response and the involvement of OMSs in omental metastases.

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“…reported delayed onset of multiple cutaneous IH after 7 months of propranolol treatment. Beta‐adrenergic‐blocking drugs may also be useful in preventing the growth of various cancers with high angiogenic potential . Propranolol may not only be therapeutic but also prophylactic.…”

Section: Discussionmentioning

confidence: 99%

Prolonged growth of infantile hemangioma after pulsed dye laser and oral propranolol treatment

Kagami

Kaneko

Kishi

et al. 2018

The Journal of Dermatology

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Infantile hemangiomas are the most common tumor of childhood and undergo rapid growth during early infancy followed by gradual involution. After involution, residual lesions sometimes remain. Oral propranolol usually induces earlier involution and redness reduction of infantile hemangiomas. However, the optimal treatment duration is unknown and infantile hemangiomas sometimes recur after cessation of treatment. We report three Japanese patients with recurrent infantile hemangiomas on their cheek. These patients were a 1-month-old female baby with a superficial infantile hemangioma, a 3-month-old female baby with a mixed infantile hemangioma and a 4-month-old male baby with a mixed infantile hemangioma. Two of them also received pulsed dye laser treatment. They did not reach complete or nearly complete resolution of infantile hemangiomas at week 25. These patients experienced regrowth of their infantile hemangioma after 20 months of age and took propranolol after the age of 24 months. There were no severe adverse effects. Propranolol may not only be therapeutic but also prophylactic. Patients with infantile hemangiomas who have taken oral propranolol should be followed up at least 6 months after cessation of treatment, especially infantile hemangiomas on the cheek, and those with partial response to propranolol may require close attention in prolonged growth.

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β-Adrenergic modulation of cancer cell proliferation: available evidence and clinical perspectives

Cited by 78 publications

References 97 publications

Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development

Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development

Sympathetic nerve tissue in milky spots of the human greater omentum

Prolonged growth of infantile hemangioma after pulsed dye laser and oral propranolol treatment

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